Emeritus ProfessorJeremyNicholson

NICHOLSON JK, SADLER PJ, CAIN K, HOLT DE, WEBB M, HAWKES GEet al., 1983, 88MHZ CD-113-NMR STUDIES OF NATIVE RAT-LIVER METALLOTHIONEINS, BIOCHEMICAL JOURNAL, Vol: 211, Pages: 251-255, ISSN: 0264-6021

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• Citations: 18

NICHOLSON JK, BUCKINGHAM MJ, SADLER PJ, 1983, HIGH-RESOLUTION H-1-NMR STUDIES OF VERTEBRATE BLOOD AND PLASMA, BIOCHEMICAL JOURNAL, Vol: 211, Pages: 605-615, ISSN: 0264-6021

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• Citations: 228

APPLETON TC, KENDALL MD, NICHOLSON JK, WARLEY Aet al., 1983, CONCENTRATIONS OF SOME NATURALLY-OCCURRING ELEMENTS IN THE PROXIMAL AND DISTAL TUBULES OF MICE, AND THE EFFECT OF TREATMENT WITH CADMIUM CHLORIDE ON THESE LEVELS, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 339, Pages: P46-P46, ISSN: 0022-3751

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Nicholson JK, 1982, The microanatomy of the distal tubules, collecting tubules and collecting ducts of the starling kidney, Journal of Anatomy, Vol: 134, Pages: 11-23, ISSN: 0021-8782

Light and electron microscopic techniques were employed to characterise the various cell types found in the distal tubules, collecting tubules and collecting ducts in the kidneys of wild starlings (Sturnus vulgaris). There was a gradual change in cell characteristics along the length of the distal tubule. A short transition zone was identified, between the distal tubule and the intralobular collecting tubule, which contained cell types that were characteristic of both segments. The end of the distal tubule was marked by the appearance of scattered dark cells and occasional mucin-secreting cells. The dark cells were electron-dense and usually possessed many microvesicles in the subapical region; there were also numerous, stubby apical microprocesses in many cases. In the basal regions of these cells were many short, regular infoldings of the plasma membrane. The initial part of the intralobular collecting tubule was lined by approximately equal numbers of dark and mucin-secreting cells. However, as the tubule progressed towards the lobular periphery, the number of dark cells declined. Few dark cells were observed in the perilobular collecting ducts and none in the medullary ducts which were lined by columnar mucin-secreting cells. The mucin-secreting cells possessed a prominent supranuclear Golgi apparatus and apical vacuoles containing a strongly PAS- and alcian blue-positive mucigen. Critical electrolyte concentration methods, using alcian blue in the presence of magnesium chloride, indicated that the mucigen contained large amounts of a strongly sulphated component, but was probably of a mixed nature. The dark cells were slightly PAS-positive but only very weakly blue-positive at the cell apices. The roles of the various cell types were discussed in relation to the uric acid excretion habit of birds.

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• Citations: 24

NICHOLSON JK, 1982, THE MICROANATOMY OF THE DISTAL TUBULES, COLLECTING TUBULES AND COLLECTING DUCTS OF THE STARLING KIDNEY, JOURNAL OF ANATOMY, Vol: 134, Pages: 11-23, ISSN: 0021-8782

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• Citations: 30

Nicholson JK, Kendall MD, 1981, Comparative nephrotoxicity of cadmium and mercury in experimental animals in relation to tissue metal pharmacodynamics, Cell Biology International Reports, Vol: 5, ISSN: 0309-1651

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Nicholson JK, Kendall MD, 1981, Cadmium and mercury induced kidney lesions in experimental animals in relation to tissue metal dynamics, Journal of Applied Toxicology, Vol: 1, ISSN: 0260-437X

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• Citations: 1

NICHOLSON JK, 1981, EVIDENCE OF NEPHROTOXIC LESIONS IN THE KIDNEYS OF WILD SEABIRDS CARRYING HEAVY LOADS OF CADMIUM AND MERCURY, JOURNAL OF ANATOMY, Vol: 132, Pages: 472-472, ISSN: 0021-8782

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KENDALL MD, NICHOLSON JK, 1981, PRELIMINARY-X-RAY MICROANALYSIS OF MOUSE PROXIMAL TUBULE CELLS, JOURNAL OF ANATOMY, Vol: 132, Pages: 480-480, ISSN: 0021-8782

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• Citations: 3

NICHOLSON JK, 1981, THE COMPARATIVE DISTRIBUTION OF ZINC, CADMIUM AND MERCURY IN SELECTED TISSUES OF THE HERRING GULL (LARUS-ARGENTATUS), COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY, Vol: 68, Pages: 91-94, ISSN: 0742-8413

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• Citations: 37

OSBORN D, HARRIS MP, NICHOLSON JK, 1979, COMPARATIVE TISSUE DISTRIBUTION OF MERCURY, CADMIUM AND ZINC IN 3 SPECIES OF PELAGIC SEABIRDS, COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY, Vol: 64, Pages: 61-67, ISSN: 0742-8413

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• Citations: 78

Claus SP, Ellero SL, Berger B, Krause L, Bruttin A, Molina J, Paris A, Want EJ, de Waziers I, Cloarec O, Richards SE, Wang Y, Dumas M-E, Ross A, Rezzi S, Kochhar S, Van Bladeren P, Lindon JC, Holmes E, Nicholson JKet al., Colonization-Induced Host-Gut Microbial Metabolic Interaction, MBIO, Vol: 2, ISSN: 2150-7511

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• Citations: 307

Gibb JOT, Svendsen C, Weeks JM, Nicholson JKet al., H-1 NMR spectroscopic investigations of tissue metabolite biomarker response to Cu(II) exposure in terrestrial invertebrates: identification of free histidine as a novel biomarker of exposure to copper in earthworms, BIOMARKERS, Vol: 2, Pages: 295-302, ISSN: 1354-750X

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• Citations: 51