Imperial College London
Alternate

Emeritus ProfessorJeremyNicholson

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Emeritus Professor of Biological Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 3195j.nicholson Website

 
 
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Assistant

 

Ms Wendy Torto +44 (0)20 7594 3225

 
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Location

 

Office no. 665Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Adesina-Georgiadis:2018:10.1080/00498254.2018.1559376,
author = {Adesina-Georgiadis, KN and Gray, N and Plumb, RS and Thompson, DF and Holmes, E and Nicholson, JK and Wilson, ID},
doi = {10.1080/00498254.2018.1559376},
journal = {Xenobiotica},
title = {The metabolic fate and effects of 2-bromophenol in male Sprague-Dawley rats},
url = {http://dx.doi.org/10.1080/00498254.2018.1559376},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - 1. The metabolic fate and urinary excretion of 2-bromophenol, a phenolic metabolite of bromobenzene, was investigated in male Sprague Dawley rats following single intraperitoneal doses at either 0, 100 or 200 mg/kg. 2. Urine was collected for seven days and samples analysed using 1H NMR spectroscopy, inductively coupled plasma (ICP)MS, and UPLC-MS. 3. 1H NMR spectroscopy of the urine samples showed that, at these doses, 2-bromophenol had little effect on endogenous metabolite profiles, supporting histopathology and clinical chemistry data which showed no changes associated with the administration of 2-bromophenol at these doses. 4. The use of ICP-MS Provided a means for the selective detection and quantification of bromine-containing species and showed that between 15 and 30% of the dose was excreted via the urine over the 7 days of the study for both the 100 and 200 mg doses respectively. 6. The bulk of the excretion of Br-containing material had occurred by 8 hr post administration. UPLC-MS of urine revealed a number of metabolites of 2-bromophenol, with 2-bromophenol glucuronide and 2-bromophenol sulphate identified as the major species. A number of minor hydroxylated metabolites were also detected as their glucuronide, sulphate or O-methyl conjugates. There was no evidence for the production of reactive metabolites.
AU  - Adesina-Georgiadis,KN
AU  - Gray,N
AU  - Plumb,RS
AU  - Thompson,DF
AU  - Holmes,E
AU  - Nicholson,JK
AU  - Wilson,ID
DO  - 10.1080/00498254.2018.1559376
PY  - 2018///
SN  - 0049-8254
TI  - The metabolic fate and effects of 2-bromophenol in male Sprague-Dawley rats
T2  - Xenobiotica
UR  - http://dx.doi.org/10.1080/00498254.2018.1559376
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30557119
UR  - http://hdl.handle.net/10044/1/65434
ER  -
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