Imperial College London
Alternate

Emeritus ProfessorJeremyNicholson

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Emeritus Professor of Biological Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 3195j.nicholson Website

 
 
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Assistant

 

Ms Wendy Torto +44 (0)20 7594 3225

 
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Location

 

Office no. 665Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kundu:2019:10.1126/scitranslmed.aau4760,
author = {Kundu, P and Lee, HU and Garcia-Perez, I and Tay, EXY and Kim, H and Faylon, LE and Martin, KA and Purbojati, R and Drautz-Moses, DI and Ghosh, S and Nicholson, JK and Schuster, S and Holmes, E and Pettersson, S},
doi = {10.1126/scitranslmed.aau4760},
journal = {Science Translational Medicine},
pages = {1--13},
title = {Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice.},
url = {http://dx.doi.org/10.1126/scitranslmed.aau4760},
volume = {11},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The gut microbiota evolves as the host ages, yet the effects of these microbial changes on host physiology and energy homeostasis are poorly understood. To investigate these potential effects, we transplanted the gut microbiota of old or young mice into young germ-free recipient mice. Both groups showed similar weight gain and skeletal muscle mass, but germ-free mice receiving a gut microbiota transplant from old donor mice unexpectedly showed increased neurogenesis in the hippocampus of the brain and increased intestinal growth. Metagenomic analysis revealed age-sensitive enrichment in butyrate-producing microbes in young germ-free mice transplanted with the gut microbiota of old donor mice. The higher concentration of gut microbiota-derived butyrate in these young transplanted mice was associated with an increase in the pleiotropic and prolongevity hormone fibroblast growth factor 21 (FGF21). An increase in FGF21 correlated with increased AMPK and SIRT-1 activation and reduced mTOR signaling. Young germ-free mice treated with exogenous sodium butyrate recapitulated the prolongevity phenotype observed in young germ-free mice receiving a gut microbiota transplant from old donor mice. These results suggest that gut microbiota transplants from aged hosts conferred beneficial effects in responsive young recipients.
AU  - Kundu,P
AU  - Lee,HU
AU  - Garcia-Perez,I
AU  - Tay,EXY
AU  - Kim,H
AU  - Faylon,LE
AU  - Martin,KA
AU  - Purbojati,R
AU  - Drautz-Moses,DI
AU  - Ghosh,S
AU  - Nicholson,JK
AU  - Schuster,S
AU  - Holmes,E
AU  - Pettersson,S
DO  - 10.1126/scitranslmed.aau4760
EP  - 13
PY  - 2019///
SN  - 1946-6234
SP  - 1
TI  - Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice.
T2  - Science Translational Medicine
UR  - http://dx.doi.org/10.1126/scitranslmed.aau4760
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31723038
UR  - https://stm.sciencemag.org/content/11/518/eaau4760
UR  - http://hdl.handle.net/10044/1/75082
VL  - 11
ER  -
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