Imperial College London
Alternate

Emeritus ProfessorJeremyNicholson

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Emeritus Professor of Biological Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 3195j.nicholson Website

 
 
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Assistant

 

Ms Wendy Torto +44 (0)20 7594 3225

 
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Location

 

Office no. 665Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{West:2020:10.1136/gutjnl-2019-319620,
author = {West, K and Kanu, C and Maric, T and McDonald, J and Nicholson, J and Li, J and Johnson, M and Holmes, E and Savvidou, M},
doi = {10.1136/gutjnl-2019-319620},
journal = {Gut},
pages = {1452--1459},
title = {Longitudinal metabolic and gut bacterial profiling of pregnant women with previous bariatric surgery},
url = {http://dx.doi.org/10.1136/gutjnl-2019-319620},
volume = {69},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Due to the global increase in obesity rates and success of bariatric surgery in weight reduction, an increasing number of women now present pregnant with a previous bariatric procedure. This study investigates the extent of bariatric-associated metabolic and gut microbial alterations during pregnancy and their impact on fetal development.DesignA parallel metabonomic (1H NMR spectroscopy) and gut bacterial (16S rRNA gene amplicon sequencing) profiling approach was used to determine maternal longitudinal phenotypes associated with malabsorptive/mixed (n=25) or restrictive (n=16) procedures, compared to women with similar early pregnancy body mass index but without bariatric surgery (n=70). Metabolic profiles of offspring at birth were also analysed.ResultsPrevious malabsorptive, but not restrictive, procedures induced significant changes in maternal metabolic pathways involving branched-chain and aromatic amino acids with decreased circulation of leucine, isoleucine and isobutyrate, increased excretion of microbial-associated metabolites of protein putrefaction (phenylacetlyglutamine, p-cresol sulfate, indoxyl sulfate and p-hydroxyphenylacetate), and a shift in the gut microbiota. Urinary concentration of phenylacetylglutamine was significantly elevated in malabsorptive patients relative to controls (P=0.001) and was also elevated in urine of neonates born from these mothers (P=0.021). Furthermore, the maternal metabolic changes induced by malabsorptive surgery were associated with reduced maternal insulin resistance and fetal/birth weight.ConclusionMetabolism is altered in pregnant women with a previous malabsorptive bariatric surgery. These alterations may be beneficial for maternal outcomes, but the effect of elevated levels of phenolic and indolic compounds on fetal and infant health should be investigated further.
AU  - West,K
AU  - Kanu,C
AU  - Maric,T
AU  - McDonald,J
AU  - Nicholson,J
AU  - Li,J
AU  - Johnson,M
AU  - Holmes,E
AU  - Savvidou,M
DO  - 10.1136/gutjnl-2019-319620
EP  - 1459
PY  - 2020///
SN  - 0017-5749
SP  - 1452
TI  - Longitudinal metabolic and gut bacterial profiling of pregnant women with previous bariatric surgery
T2  - Gut
UR  - http://dx.doi.org/10.1136/gutjnl-2019-319620
UR  - http://hdl.handle.net/10044/1/75595
VL  - 69
ER  -
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