Imperial College London
Alternate

Emeritus ProfessorJeremyNicholson

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Emeritus Professor of Biological Chemistry
 
 
 
//

Contact

 

+44 (0)20 7594 3195j.nicholson Website

 
 
//

Assistant

 

Ms Wendy Torto +44 (0)20 7594 3225

 
//

Location

 

Office no. 665Sir Alexander Fleming BuildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Lawler:2021:10.1021/acs.jproteome.1c00052,
author = {Lawler, NG and Gray, N and Kimhofer, T and Boughton, B and Gay, M and Yang, R and Morillon, A-C and Chin, S-T and Ryan, M and Begum, S and Bong, SH and Coudert, JD and Edgar, D and Raby, E and Pettersson, S and Richards, T and Holmes, E and Whiley, L and Nicholson, JK},
doi = {10.1021/acs.jproteome.1c00052},
journal = {Journal of Proteome Research},
pages = {2796--2811},
title = {Systemic perturbations in amine and kynurenine metabolism associated with acute SARS-CoV-2 infection and inflammatory cytokine responses},
url = {http://dx.doi.org/10.1021/acs.jproteome.1c00052},
volume = {20},
year = {2021}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - We performed quantitative metabolic phenotyping of blood plasma in parallel with cytokine/chemokine analysis from participants who were either SARS-CoV-2 (+) (n = 10) or SARS-CoV-2 (-) (n = 49). SARS-CoV-2 positivity was associated with a unique metabolic phenotype and demonstrated a complex systemic response to infection, including severe perturbations in amino acid and kynurenine metabolic pathways. Nine metabolites were elevated in plasma and strongly associated with infection (quinolinic acid, glutamic acid, nicotinic acid, aspartic acid, neopterin, kynurenine, phenylalanine, 3-hydroxykynurenine, and taurine; p < 0.05), while four metabolites were lower in infection (tryptophan, histidine, indole-3-acetic acid, and citrulline; p < 0.05). This signature supports a systemic metabolic phenoconversion following infection, indicating possible neurotoxicity and neurological disruption (elevations of 3-hydroxykynurenine and quinolinic acid) and liver dysfunction (reduction in Fischer’s ratio and elevation of taurine). Finally, we report correlations between the key metabolite changes observed in the disease with concentrations of proinflammatory cytokines and chemokines showing strong immunometabolic disorder in response to SARS-CoV-2 infection.
AU  - Lawler,NG
AU  - Gray,N
AU  - Kimhofer,T
AU  - Boughton,B
AU  - Gay,M
AU  - Yang,R
AU  - Morillon,A-C
AU  - Chin,S-T
AU  - Ryan,M
AU  - Begum,S
AU  - Bong,SH
AU  - Coudert,JD
AU  - Edgar,D
AU  - Raby,E
AU  - Pettersson,S
AU  - Richards,T
AU  - Holmes,E
AU  - Whiley,L
AU  - Nicholson,JK
DO  - 10.1021/acs.jproteome.1c00052
EP  - 2811
PY  - 2021///
SN  - 1535-3893
SP  - 2796
TI  - Systemic perturbations in amine and kynurenine metabolism associated with acute SARS-CoV-2 infection and inflammatory cytokine responses
T2  - Journal of Proteome Research
UR  - http://dx.doi.org/10.1021/acs.jproteome.1c00052
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000649269600055&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://pubs.acs.org/doi/10.1021/acs.jproteome.1c00052
UR  - http://hdl.handle.net/10044/1/91210
VL  - 20
ER  -
Download