Imperial College London
Alternate

Emeritus ProfessorJeremyNicholson

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Emeritus Professor of Biological Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 3195j.nicholson Website

 
 
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Assistant

 

Ms Wendy Torto +44 (0)20 7594 3225

 
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Location

 

Office no. 665Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Yeap:2022:10.1530/EJE-22-0104,
author = {Yeap, BB and Marriott, RJ and Manning, L and Dwivedi, G and Hankey, GJ and Wu, FCW and Nicholson, JK and Murray, K},
doi = {10.1530/EJE-22-0104},
journal = {European Journal of Endocrinology},
pages = {159--170},
title = {Higher premorbid serum testosterone predicts COVID-19-related mortality risk in men.},
url = {http://dx.doi.org/10.1530/EJE-22-0104},
volume = {187},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objective: Men are at greater risk from COVID-19 than women. Older, overweight men, and those with type 2 diabetes, have lower testosterone concentrations and poorer COVID-19-related outcomes. We analysed the associations of premorbid serum testosterone concentrations, not confounded by the effects of acute SARS-CoV-2 infection, with COVID-19-related mortality risk in men. Design: This study is a United Kingdom Biobank prospective cohort study of community-dwelling men aged 40-69 years. Methods: Serum total testosterone and sex hormone-binding globulin (SHBG) were measured at baseline (2006-2010). Free testosterone values were calculated (cFT). the incidence of SARS-CoV-2 infections and deaths related to COVID-19 were ascertained from 16 March 2020 to 31 January 2021 and modelled using time-stratified Cox regression. Results: In 159 964 men, there were 5558 SARS-CoV-2 infections and 438 COVID-19 deaths. Younger age, higher BMI, non-White ethnicity, lower educational attainment, and socioeconomic deprivation were associated with incidence of SARS-CoV-2 infections but total testosterone, SHBG, and cFT were not. Adjusting for potential confounders, higher total testosterone was associated with COVID-19-related mortality risk (overall trend P = 0.008; hazard ratios (95% CIs) quintile 1, Q1 vs Q5 (reference), 0.84 (0.65-1.12) Q2:Q5, 0.82 (0.63-1.10); Q3:Q5, 0.80 (0.66-1.00); Q4:Q5, 0.82 (0.75-0.93)). Higher SHBG was also associated with COVID-19 mortality risk (P = 0.008), but cFT was not (P = 0.248). Conclusions: Middle-aged to older men with the highest premorbid serum total testosterone and SHBG concentrations are at greater risk of COVID-19-related mortality. Men could be advised that having relatively high serum testosterone concentrations does not protect against future COVID-19-related mortality. Further investigation of causality and potential underlying mechanisms is warranted.
AU  - Yeap,BB
AU  - Marriott,RJ
AU  - Manning,L
AU  - Dwivedi,G
AU  - Hankey,GJ
AU  - Wu,FCW
AU  - Nicholson,JK
AU  - Murray,K
DO  - 10.1530/EJE-22-0104
EP  - 170
PY  - 2022///
SN  - 0804-4643
SP  - 159
TI  - Higher premorbid serum testosterone predicts COVID-19-related mortality risk in men.
T2  - European Journal of Endocrinology
UR  - http://dx.doi.org/10.1530/EJE-22-0104
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35536887
UR  - https://eje.bioscientifica.com/view/journals/eje/187/1/EJE-22-0104.xml
UR  - http://hdl.handle.net/10044/1/97444
VL  - 187
ER  -
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