Imperial College London
Alternate

Emeritus ProfessorJohnWarner

Faculty of Medicine, National Heart & Lung Institute

Emeritus in Paediatrics
 
 
 
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Contact

 

j.o.warner

 
 
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Location

 

246Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bjermer:2019:10.1016/j.rmed.2018.12.006,
author = {Bjermer, L and Eriksson, G and Radner, F and Peterson, S and Warner, JO},
doi = {10.1016/j.rmed.2018.12.006},
journal = {Respiratory Medicine},
pages = {19--25},
title = {Time to onset of improvements in Quality of Life from Temperature-controlled Laminar Airflow (TLA) in severe allergic asthma},
url = {http://dx.doi.org/10.1016/j.rmed.2018.12.006},
volume = {147},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundAllergen avoidance is important in allergic asthma management. Nocturnal treatment with Temperature-controlled Laminar Airflow (TLA; Airsonett®) has been shown to provide significant reduction of exposure to allergens in the breathing zone, leading to long-term reduction in airway inflammation and improvement in quality of life. Allergic asthma patients uncontrolled on GINA step 4 were found to benefit the most. A frequently asked question from clinicians and funders is related to time to onset (TTO) of improvements for patients using TLA.MethodsAsthma Quality of Life Questionnaire (AQLQ) scores were collected in a previous study. TTO of improvements in Quality of Life was analysed for difference (TLA-placebo) in Area-under-Curve using backwards deletion from 12, 9, 6, 3 down to 1 month for the AQLQ total score, the four individual domains and specifically the sleep question.ResultsPatients with uncontrolled asthma on GINA step 4 (n=87)) reported a statistically significant and clinically relevant (≥0.5 point) improvement in total AQLQ score (0.57; p=0.009) after 3 months treatment for TLA over placebo. The shortest TTO was within 1 month for the environmental domain (0.68; p=0.016) and the sleep question (0.771; p=0.037). TTO for the emotional and symptom domains was 3 months (0.66; p=0.020 and 0.64; p=0.014 respectively) and for the activity domain 6 months (0.47; p=0.036).ConclusionNocturnal avoidance of allergens using TLA provided a statistically significant and clinically relevant improvement in total AQLQ score within 3 months in patients in the GINA 4 + ACT<18 group. Questions related to sleep quality may provide the first signal of response already within a month after commencing treatment.
AU  - Bjermer,L
AU  - Eriksson,G
AU  - Radner,F
AU  - Peterson,S
AU  - Warner,JO
DO  - 10.1016/j.rmed.2018.12.006
EP  - 25
PY  - 2019///
SN  - 0954-6111
SP  - 19
TI  - Time to onset of improvements in Quality of Life from Temperature-controlled Laminar Airflow (TLA) in severe allergic asthma
T2  - Respiratory Medicine
UR  - http://dx.doi.org/10.1016/j.rmed.2018.12.006
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000456823800004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/69093
VL  - 147
ER  -
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