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@article{Osmanov:2021:10.1101/2021.04.26.21256110,
author = {Osmanov, IM and Spiridonova, E and Bobkova, P and Gamirova, A and Shikhaleva, A and Andreeva, M and Blyuss, O and El-Taravi, Y and DunnGalvin, A and Comberiati, P and Peroni, DG and Apfelbacher, C and Genuneit, J and Mazankova, L and Miroshina, A and Chistyakova, E and Samitova, E and Borzakova, S and Bondarenko, E and Korsunskiy, AA and Konova, I and Hanson, SW and Carson, G and Sigfrid, L and Scott, JT and Greenhawt, M and Whittaker, EA and Garralda, E and Swann, O and Buonsenso, D and Nicholls, DE and Simpson, F and Jones, C and Semple, MG and Warner, JO and Vos, T and Olliaro, P and Munblit, D},
doi = {10.1101/2021.04.26.21256110},
title = {Risk factors for long covid in previously hospitalised children using the ISARIC Global follow-up protocol: A prospective cohort study},
url = {http://dx.doi.org/10.1101/2021.04.26.21256110},
year = {2021}
}

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TY  - JOUR
AB  - <jats:p>Background The long-term sequelae of coronavirus disease 2019 (Covid-19) in children remain poorly characterised. This study aimed to assess long-term outcomes in children previously hospitalised with Covid-19 and associated risk factors.Methods This is a prospective cohort study of children (18 years old and younger) admitted with confirmed Covid-19 to Z.A. Bashlyaeva Children's Municipal Clinical Hospital in Moscow, Russia. Children admitted to the hospital during the first wave of the pandemic, between April 2, 2020 and August 26, 2020, were included. Telephone interview using the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) Covid-19 Health and Wellbeing paediatric follow up survey. Persistent symptoms (>5 months) were further categorised by system(s) involved. Findings Overall, 518 of 853 (61%) of eligible children were available for the follow-up assessment and included in the study. Median age was 10.4 years (IQR, 3-15.2) and 270 (52.1%) were girls; median follow-up since hospital discharge was 256 (223-271) days. At the time of the follow-up interview 126 (24.3%) participants reported persistent symptoms among which fatigue (53, 10.7%), sleep disturbance (36, 6.9%,) and sensory problems (29, 5.6%) were the most common. Multiple symptoms were experienced by 44 (8.4%) participants. Risk factors for persistent symptoms were: age "6-11 years" (odds ratio 2.74 (95% confidence interval 1.37 to 5.75) and "12-18 years" (2.68, 1.41 to 5.4), and a history of allergic diseases (1.67, 1.04 to 2.67).Interpretation A quarter of children experienced persistent symptoms months after hospitalization with acute covid-19 infection, with almost one in ten experiencing multi-system involvement. Older age and allergic diseases were associated with higher risk of persistent symptoms at follow-up. Our findings highlight the need for replication and further investigation of potential mechanisms as well as c
AU  - Osmanov,IM
AU  - Spiridonova,E
AU  - Bobkova,P
AU  - Gamirova,A
AU  - Shikhaleva,A
AU  - Andreeva,M
AU  - Blyuss,O
AU  - El-Taravi,Y
AU  - DunnGalvin,A
AU  - Comberiati,P
AU  - Peroni,DG
AU  - Apfelbacher,C
AU  - Genuneit,J
AU  - Mazankova,L
AU  - Miroshina,A
AU  - Chistyakova,E
AU  - Samitova,E
AU  - Borzakova,S
AU  - Bondarenko,E
AU  - Korsunskiy,AA
AU  - Konova,I
AU  - Hanson,SW
AU  - Carson,G
AU  - Sigfrid,L
AU  - Scott,JT
AU  - Greenhawt,M
AU  - Whittaker,EA
AU  - Garralda,E
AU  - Swann,O
AU  - Buonsenso,D
AU  - Nicholls,DE
AU  - Simpson,F
AU  - Jones,C
AU  - Semple,MG
AU  - Warner,JO
AU  - Vos,T
AU  - Olliaro,P
AU  - Munblit,D
DO  - 10.1101/2021.04.26.21256110
PY  - 2021///
TI  - Risk factors for long covid in previously hospitalised children using the ISARIC Global follow-up protocol: A prospective cohort study
UR  - http://dx.doi.org/10.1101/2021.04.26.21256110
ER  -

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