Publications
151 results found
Auguet OT, Betley JR, Stabler RA, et al., 2016, Evidence for Community Transmission of Community-Associated but Not Health-Care-Associated Methicillin-Resistant Staphylococcus Aureus Strains Linked to Social and Material Deprivation: Spatial Analysis of Cross-sectional Data, PLoS Medicine, Vol: 13, ISSN: 1549-1277
Brown C, Livermore DM, Otter JA, et al., 2016, Multidrug-resistant (MDR) Gram-negative bacteria information leaflets, Journal of Hospital Infection, Vol: 92, Pages: 86-87, ISSN: 0195-6701
Wilson APR, Livermore DM, Otter JA, et al., 2016, Prevention and control of multi-drug-resistant Gram-negative bacteria: recommendations from a Joint Working Party, Journal of Hospital Infection, Vol: 92, Pages: S1-S44, ISSN: 0195-6701
Otter JA, 2016, Reflections from Infection Prevention 2015: beating the bugs, improving the systems and thinking outside the box., Journal of Infection Prevention, Vol: 17, Pages: 37-41, ISSN: 1757-1782
Horn K, Otter JA, 2015, Hydrogen peroxide vapor room disinfection and hand hygiene improvements reduce <i>Clostridium difficile</i> infection, methicillin-resistant <i>Staphylococcus aureus</i>, vancomycin-resistant enterococci, and extended-spectrum β-lactamase, AMERICAN JOURNAL OF INFECTION CONTROL, Vol: 43, Pages: 1354-1356, ISSN: 0196-6553
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- Citations: 19
Hughes J, Stabler R, Gaunt M, et al., 2015, Clonal variation in high- and low-level phenotypic and genotypic mupirocin resistance of MRSA isolates in south-east London, JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, Vol: 70, Pages: 3191-3199, ISSN: 0305-7453
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- Citations: 13
Otter JA, Mutters NT, Tacconelli E, et al., 2015, Controversies in guidelines for the control of multidrug-resistant Gram-negative bacteria in EU countries, CLINICAL MICROBIOLOGY AND INFECTION, Vol: 21, Pages: 1057-1066, ISSN: 1198-743X
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- Citations: 59
Otter JA, 2015, The inaugural Healthcare Infection Society Middle East Summit: 'No action today. No cure tomorrow', JOURNAL OF HOSPITAL INFECTION, Vol: 91, Pages: 199-201, ISSN: 0195-6701
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- Citations: 1
Otter JA, 2015, Biofilms mean that the 'environmentome' of hospital surfaces is teeming with life, JOURNAL OF HOSPITAL INFECTION, Vol: 91, Pages: 218-219, ISSN: 0195-6701
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- Citations: 2
Fisher D, Pang L, Salmon S, et al., 2015, A Successful Vancomycin-Resistant Enterococci Reduction Bundle at a Singapore Hospital, Infection Control and Hospital Epidemiology, Vol: 37, Pages: 107-109, ISSN: 0899-823X
Biswas JS, Patel A, Otter JA, et al., 2015, Contamination of the Hospital Environment From Potential <i>Clostridium difficile</i> Excretors Without Active Infection, INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, Vol: 36, Pages: 975-977, ISSN: 0899-823X
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- Citations: 13
Biswas JS, Patel A, Otter JA, et al., 2015, Reduction in <i>Clostridium difficile</i> environmental contamination by hospitalized patients treated with fidaxomicin, JOURNAL OF HOSPITAL INFECTION, Vol: 90, Pages: 267-270, ISSN: 0195-6701
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- Citations: 18
Otter JA, 2015, Journal Roundup, JOURNAL OF HOSPITAL INFECTION, Vol: 90, Pages: 175-176, ISSN: 0195-6701
Otter J, 2015, Journal Roundup: Ebola, antibiotic use and abuse, and the usual suspects, JOURNAL OF HOSPITAL INFECTION, Vol: 90, Pages: 85-86, ISSN: 0195-6701
Otter JA, 2015, What's trending in the infection prevention and control literature? From HIS 2012 to HIS 2014, and beyond, JOURNAL OF HOSPITAL INFECTION, Vol: 89, Pages: 229-236, ISSN: 0195-6701
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- Citations: 5
Lemmen S, Scheithauer S, Haefner H, et al., 2015, Evaluation of hydrogen peroxide vapor for the inactivation of nosocomial pathogens on porous and nonporous surfaces, AMERICAN JOURNAL OF INFECTION CONTROL, Vol: 43, Pages: 82-85, ISSN: 0196-6553
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- Citations: 33
Otter JA, Vickery K, Walker JT, et al., 2015, Surface-attached cells, biofilms and biocide susceptibility: implications for hospital cleaning and disinfection, JOURNAL OF HOSPITAL INFECTION, Vol: 89, Pages: 16-27, ISSN: 0195-6701
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- Citations: 141
Otter JA, 2015, Journal Roundup: Ebola (again), the rise (and rise) and fall of MDROs, and Infection Prevention 2014 Conference, Glasgow, JOURNAL OF HOSPITAL INFECTION, Vol: 89, Pages: 74-76, ISSN: 0195-6701
Yezli S, Barbut F, Otter JA, 2014, Surface Contamination in Operating Rooms: A Risk for Transmission of Pathogens?, SURGICAL INFECTIONS, Vol: 15, Pages: 694-699, ISSN: 1096-2964
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- Citations: 24
Otter JA, 2014, Journal Roundup, JOURNAL OF HOSPITAL INFECTION, Vol: 88, Pages: 181-182, ISSN: 0195-6701
Otter JA, 2014, Journal Roundup, JOURNAL OF HOSPITAL INFECTION, Vol: 88, Pages: 124-126, ISSN: 0195-6701
Otter JA, 2014, Journal roundup, The Journal of hospital infection, Vol: 88, Pages: 55-57
Otter JA, 2014, Journal Roundup, JOURNAL OF HOSPITAL INFECTION, Vol: 88, Pages: 55-57, ISSN: 0195-6701
Curran ET, Otter JA, 2014, Outbreak Column 15: Carbapenemase-producing Enterobacteriaceae., J Infect Prev, Vol: 15, Pages: 193-198, ISSN: 1757-1774
Otter JA, 2014, An overview of the options for antimicrobial hard surfaces in hospitals, Use of Biocidal Surfaces for Reduction of Healthcare Acquired Infections, Pages: 137-166, ISBN: 9783319080567
Contaminated surfaces make an important contribution to the transmission of several important pathogens, including methicillin-resistant Staphylococcus aureus (MRSA), Clostridium difficile and a number of resistant Gram-negative rods, including Acinetobacter baumannii. Several different approaches are available for improving hospital hygiene, including improving the effectiveness of existing methods and a range of new approaches, including novel disinfectants. A complimentary approach is the introduction of antimicrobial surfaces (AMS), which exert a continuous reduction on the level of microbial contamination on hospitals surfaces. There are several approaches to making a hospital surface 'antimicrobial': permanently 'manufacture in' an agent with antimicrobial activity; periodically apply an agent with antimicrobial activity; or physically alter the properties of a surface to make it less able to support microbial contamination and/or easier to clean. Promising options for AMS in healthcare settings include metals (principally copper or silver), chemicals (organosilanes, quaternary ammonium compounds, light-activated antimicrobials, and polycationic polymers) and physical alteration of the surface to reduce microbial attachment or improve cleanability. Before widespread adoption of AMS, promising candidates require rigorous in vitro and in situ assessment, including an evaluation of their clinical impact and cost effectiveness. Copper alloy surfaces are the most closely evaluated option for AMS, and have demonstrated in vitro activity against a range of pathogens (although their sporicidal capacity remains equivocal), evidence of efficacy in in situ studies and their introduction has been associated with a reduction in healthcare-associated infections (HAI). However, their long-term durability, acceptability and cost-effectiveness have not been evaluated formally. Finding and evaluating the optimal AMS will require a multidisciplinary approach, involving industria
Otter JA, Yezli S, French GL, 2014, The role of contaminated surfaces in the transmission of nosocomial pathogens, Use of Biocidal Surfaces for Reduction of Healthcare Acquired Infections, Pages: 27-58, ISBN: 9783319080567
Studies in the 1970s and 1980s suggested that environmental surface contamination had a negligible role in the endemic transmission of healthcare-associated infections. However, recent studies demonstrate that several major nosocomial pathogens are shed by patients and contaminate hospital surfaces at concentrations sufficient for transmission, survive for extended periods, persist despite attempts to disinfect or remove them and can be transferred to the hands of healthcare workers. Evidence is accumulating that contaminated surfaces make an important contribution to the epidemic and endemic transmission of C. difficile, vancomycin-resistant enterococci, methicillin-resistant Staphylococcus aureus, Acinetobacter baumannii, Pseudomonas aeruginosa and norovirus and that improved environmental decontamination contributes to the control of outbreaks. Efforts to improve environmental hygiene should include enhancing the efficacy of cleaning and disinfection and reducing the shedding of pathogens. Further high quality studies are needed to clarify the role of surfaces in nosocomial transmission and determine the effectiveness of different interventions in reducing associated infection rates.
Otter JA, Tosas-Auguet O, Herdman MT, et al., 2014, Implications of targeted versus universal admission screening for meticillin-resistant <i>Staphylococcus aureus</i> carriage in a London hospital, JOURNAL OF HOSPITAL INFECTION, Vol: 87, Pages: 171-174, ISSN: 0195-6701
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- Citations: 7
Otter JA, Davies B, Menson E, et al., 2014, Identification and control of a gentamicin resistant, meticillin susceptible Staphylococcus aureus outbreak on a neonatal unit., J Infect Prev, Vol: 15, Pages: 104-109, ISSN: 1757-1774
We describe the identification and control of an outbreak of gentamicin resistant, meticillin susceptible Staphylococcus aureus (GR-MSSA) on a 36-bed neonatal unit (NNU) in London. Control measures included admission and weekly screening for GR-MSSA, cohorting affected babies, environmental and staff screening, hydrogen peroxide vapour (HPV) for terminal disinfection of cohort rooms, and reinforcement of hand hygiene. Seventeen babies were affected by the outbreak strain over ten months; seven were infected and ten were asymptomatic carriers. The outbreak strain was gentamicin resistant and all isolates were indistinguishable by pulsed-field gel electrophoresis. The outbreak strains spread rapidly and were associated with a high rate of bacteraemia (35% of 17 affected patients had bacteraemia vs. 10% of 284 patients with MSSA prior to the outbreak, p=0.007). None of 113 staff members tested were colonised with GR-MSSA. GR-MSSA was recovered from 11.5% of 87 environmental surfaces in cohort rooms, 7.1% of 28 communal surfaces and 4.1% of 74 surfaces after conventional terminal disinfection. None of 64 surfaces sampled after HPV decontamination yielded GR-MSSA. Recovery of GR-MSSA from two high level sites suggested that the organism could have been transmitted via air. Occasional breakdown in hand hygiene compliance and contaminated environmental surfaces probably contributed to transmission.
Havill NL, Boyce JM, Otter JA, 2014, Extended Survival of Carbapenem-Resistant Enterobacteriaceae on Dry Surfaces, INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, Vol: 35, Pages: 445-447, ISSN: 0899-823X
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- Citations: 18
O'Halloran PD, Winter PK, Otter JA, et al., 2014, Aqueous oxygen peroxide treatment of VLUs in a primary care-based randomised, double-blind, placebo-controlled trial, JOURNAL OF WOUND CARE, Vol: 23, Pages: 176-190, ISSN: 0969-0700
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- Citations: 6
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