Imperial College London

Jiri Pavlu

Faculty of MedicineDepartment of Immunology and Inflammation

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 8117j.pavlu Website

 
 
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Location

 

Leuka Building R2.20Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
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118 results found

Beckerson J, Szydlo RM, Hickson M, Mactier CE, Innes AJ, Gabriel IH, Palanicawandar R, Kanfer EJ, Macdonald D, Milojkovic D, Rahemtulla A, Chaidos A, Karadimitris A, Olavarria E, Apperley JFet al., Impact of Nutrition on Non-Relapse Mortality and Acute Graft Versus Host Disease during Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies, 59th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, Publisher: American Society of Hematology, Pages: 2226-2226, ISSN: 0006-4971

Conference paper

Patel A, Jhanji S, Pavlu J, Laffan M, Ethell M, Bradshaw A, Olavarria E, Harrington K, Apperley J, Brett Set al., 2016, Mesenchymal stromal stem cell (MSC) immunotherapy for experimental septic shock: systematic review and meta-analysis with trial sequential analysis of mortality, 42nd Annual Meeting of the European Society for Blood and Marrow Transplantation, Publisher: Nature Publishing Group, Pages: S129-S129, ISSN: 1476-5365

Conference paper

Patel A, Szydlo R, Auner H, Chaidos A, Gabriel I, MacDonald D, Milojkovic D, Kanfer E, Karadimitris A, Rahemtulla A, Olavarria E, Apperley J, Pavlu Jet al., 2016, C-reactive protein (CRP) prior to myeloablative allogeneic haematopoietic stem cell transplantation is associated with early and long term survival to five years, 42nd Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation, Publisher: NATURE PUBLISHING GROUP, Pages: S213-S214, ISSN: 0268-3369

Conference paper

Innes A, Apperley J, Allwood Z, Altaf S, Chaidos A, Kanfer E, Kirschke S, Milojkovic D, MacDonald D, Pavlu J, Rahemtulla A, Slade D, Szydlo R, Olavarria E, Gabriel Iet al., 2016, Development of acute graft-versus-host disease post allogeneic stem cell transplantation results in significant episodes of recurrent and prolonged hospitalisations which are with associated a significant economic burden to stem cell transplant units, 42nd Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation, Publisher: Nature Publishing Group, Pages: S575-S576, ISSN: 1476-5365

Conference paper

Bain BJ, Heller M, Toma S, Pavlu Jet al., 2015, The cytological features of NPM1-mutated acute myeloid leukemia, AMERICAN JOURNAL OF HEMATOLOGY, Vol: 90, Pages: 560-560, ISSN: 0361-8609

Journal article

Vanhinsbergh LJ, Fleming C, Babb A, Pavlu J, Al Obaidi Met al., 2015, Azacitidine use in North West London: an update, 55th Annual Scientific Meeting of the British-Society-for-Haematology, Publisher: WILEY-BLACKWELL, Pages: 80-80, ISSN: 0007-1048

Conference paper

Sevillano B, Pavlu J, Szydlo R, Rotolo A, Khoder A, Sever M, Lasa M, Palinacawandar R, Giles C, Chaidos A, MacDonald D, Karadimitris A, Gabriel I, Marks A, Milojkovik D, Olavarria E, Rahemtulla A, Apperley J, Kanfer Eet al., 2015, LACE-conditioned allogeneic transplantation for high-risk haematological malignancies: treatment outcomes in 62 patients from a single centre, 41st Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation, Publisher: NATURE PUBLISHING GROUP, Pages: S223-S223, ISSN: 0268-3369

Conference paper

Farah N, Szydlo R, Mitul P, Sridharan M, Sawhney H, Lasa M, Mccue J, Atkins M, Kanfer E, MacDonald D, Milojkovic D, Pavlu J, Olavarria E, Rahemtulla A, Chaidos A, Gabriel I, Apperley Jet al., 2015, A Study to Validate the Rationale and Efficacy of a Pre-emptive approach to the management of Cytomegalovirus (CMV) reactivation post allogeneic haematopoietic stem cell transplantation (HSCT), 41st Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation, Publisher: NATURE PUBLISHING GROUP, Pages: S409-S410, ISSN: 0268-3369

Conference paper

Stringaris K, Sekine T, Khoder A, Alsuliman A, Razzaghi B, Sargeant R, Pavlu J, Brisley G, de Lavallade H, Sarvaria A, Marin D, Mielke S, Apperley JF, Shpall EJ, Barrett AJ, Rezvani Ket al., 2014, Leukemia-induced phenotypic and functional defects in natural killer cells predict failure to achieve remission in acute myeloid leukemia, HAEMATOLOGICA, Vol: 99, Pages: 836-847, ISSN: 0390-6078

Journal article

Palani R, Lasa M, Giles C, Erblich T, Patel A, Ghorashian S, Bray E, Loaiza S, Bradshaw A, Finn S-A, Saleem A, Haynes R, Chaidos A, Auner H, Pavlu J, Milojkovic D, Macdonald D, Kanfer E, Apperley J, Rahemtulla Aet al., 2014, HIGH DOSE ETOPOSIDE/GCSF IS A SAFE AND EFFECTIVE MOBILIZATION REGIMEN IN MULTIPLE MYELOMA: A SINGLE-INSTITUTION EXPERIENCE, 40th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation, Publisher: NATURE PUBLISHING GROUP, Pages: S534-S534, ISSN: 0268-3369

Conference paper

King C, Aylin P, Moore LSP, Pavlu J, Holmes Aet al., 2014, Syndromic surveillance of surgical site infections - A case study in coronary artery bypass graft patients, JOURNAL OF INFECTION, Vol: 68, Pages: 23-31, ISSN: 0163-4453

Journal article

Garnett C, Apperley JF, Pavlů J, 2013, Treatment and management of graft-versus-host disease: improving response and survival., Ther Adv Hematol, Vol: 4, Pages: 366-378, ISSN: 2040-6207

Graft-versus-host disease (GVHD) is a significant cause of morbidity and mortality following allogenic haematopoietic stem-cell transplantation and thus the focus of much ongoing research. Despite considerable advances in our understanding of the pathophysiology, diagnosis and predisposing factors for both acute and chronic forms of the disease, a standardised therapeutic strategy is still lacking. There is good evidence for initial treatment of both acute and chronic forms of the disease with corticosteroid therapy. However, the most effective approach to steroid-refractory disease remains controversial, with current practice based mainly on smaller studies and varying considerably between local institutions. Timely diagnosis, multidisciplinary working and good supportive care, including infection prophylaxis, are clearly important in optimizing response and survival in such patients. It is hoped that in the future systematic research strategies and the identification of novel therapeutic targets may improve outcome further. The following review aims to outline some of the existing options for the treatment and management of acute and chronic GVHD.

Journal article

Tawana K, Renneville A, Wang J, Georgiades P, Thomas X, Mialou V, Savic A, Van Delft FW, Treleaven JG, Iqbal S, Asou N, Uike N, Doehner K, Bullinger L, Stelljes M, Boedoer C, Cavenagh JD, Steinemann D, Ripperger T, Schlegelberger B, Vandenberghe P, Uyttebroeck A, Nomdedeu JF, Hjorth-Hansen H, Gale RE, Toze CL, Barnett MJ, Zombori M, Kallay K, Pavlu J, Mutsaers P, Menko FH, Thomas A, Wright C, Okosun J, Loveday C, Fenaux P, Scott H, Preudhomme C, Chelala C, Male A, Owen CJ, Smith M, Fitzgibbon Jet al., 2013, Familial AML With Germline CEBPA Mutations: Extended Clinical Outcomes and Analysis Of Secondary Mutations Using Whole Exome Sequencing, 55th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

Conference paper

Auner HW, Szydlo R, Rone A, Chaidos A, Giles C, Kanfer E, Macdonald DH, Marin D, Milojkovic D, Pavlu J, Apperley JF, Rahemtulla Aet al., 2013, Salvage autologous stem cell transplantation for multiple myeloma relapsing or progressing after up-front autologous transplantation, LEUKEMIA & LYMPHOMA, Vol: 54, Pages: 2200-2204, ISSN: 1042-8194

Journal article

Innes AJ, Beattie R, Sergeant R, Damaj G, Foroni L, Marin D, Kanfer E, Mielke S, Milojkovic D, MacDonald D, Pavlu J, Rahemtulla A, Roberts I, Slade D, Bray E, Goldman J, Apperley J, Szydlo R, Dazzi F, Rezvani Ket al., 2013, Escalating-dose HLA-mismatched DLI is safe for the treatment of leukaemia relapse following alemtuzumab-based myeloablative allo-SCT, BONE MARROW TRANSPLANTATION, Vol: 48, Pages: 1324-1328, ISSN: 0268-3369

Journal article

Deplano S, May PC, Pavlu J, 2013, Double minutes with MYC amplification in a patient with chronic myelomonocytic leukaemia transformed into acute myeloid leukaemia, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 162, Pages: 720-720, ISSN: 0007-1048

Journal article

Iskander D, Apperley JF, Pavlu J, 2013, Stem cell transplantation and high-dose chemotherapy, Advances in the Treatment of Chronic Myeloid Leukemia, Pages: 63-76, ISBN: 9781780842752

Book chapter

Auner HW, Szydlo R, Rone A, Giles C, Chaidos A, Kanfer EJ, Macdonald DH, Milojkovic D, Marin D, Pavlu J, Apperley JF, Rahemtulla Aet al., 2013, Salvage autologous stem cell transplantation for multiple myeloma relapsing or progressing after up-front autologous transplantation, BONE MARROW TRANSPLANTATION, Vol: 48, Pages: S199-S199, ISSN: 0268-3369

Journal article

Mactier CE, Beckerson J, Palanicawandar R, Lasa M, Szydlo RM, Slade D, Marin D, Milojkovic D, Kanfer EJ, Rahemtulla A, Apperley JF, Pavlu Jet al., 2013, Enteral-based nutrition is associated with better early outcomes in allogeneic myeloablative haematopoietic stem cell transplantation, 39th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S347-S347, ISSN: 0268-3369

Conference paper

Gabriel IH, Sergeant R, Szydlo R, Apperley JF, Alsuliman A, Khoder A, Goldman J, Kanfer E, de Lavallade H, Miljokovic D, Rahemtulla A, Pavlu J, Foroni L, Marin D, Rezvani Ket al., 2013, Donor KIR2DS2/DL2 genotype status is associated with an increased incidence of severe acute graft-versus-host disease following myeloablative haematopoeitic stem cell transplantation, 39th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S19-S19, ISSN: 0268-3369

Conference paper

Rotolo A, Pavlu J, Davidson H, Lasa M, Palanicawandar R, Giles C, MacDonald D, Marin D, Milojkovic D, Rahemtulla A, Apperley J, Kanfer Eet al., 2013, LACE reduced intensity conditioning for high-risk haematological malignancies: a 22-year single-centre experience, 39th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S235-S235, ISSN: 0268-3369

Conference paper

Innes AJ, Lurkins J, Szydlo R, Foroni L, Milojkovic D, Pavlu J, Marin D, Kanfer E, MacDonald D, Rahemtulla A, Loaiza S, Kirschke S, Rezvani K, Goldman J, Apperley J, Dazzi Fet al., 2013, Long-term leukaemia control following DLI is independent of disease eradication, 39th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S251-S251, ISSN: 0268-3369

Conference paper

Innes AJ, Beattie R, Sergeant R, Ghandi D, Foroni L, Marin D, Kanfer E, Mielke S, Milojkovic D, MacDonald D, Pavlu J, Rahemtulla A, Roberts I, Slade D, Bray E, Goldman J, Apperley J, Szydlo R, Dazzi F, Rezvani Ket al., 2013, HLA-mismatched donor lymphocyte infusion is safe for the treatment of leukaemia relapse following alemtuzumab-based myeloablative allogeneic stem cell transplantation, 39th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S86-S87, ISSN: 0268-3369

Conference paper

Pavlu J, Apperley JF, 2013, Allogeneic Stem Cell Transplantation for Chronic Myeloid Leukemia, CURRENT HEMATOLOGIC MALIGNANCY REPORTS, Vol: 8, Pages: 43-51, ISSN: 1558-8211

Journal article

Neave EL, Schwarb H, Shlebak A, Layton DM, Apperley JF, Pavlu Jet al., 2013, Lymphodepletion chemotherapy followed by donor leukocytes for post-transplantation relapse of myelofibrosis after previous donor leukocyte infusion failure, EUROPEAN JOURNAL OF HAEMATOLOGY, Vol: 90, Pages: 76-78, ISSN: 0902-4441

Journal article

Pavlu J, Chakrabartty J, Apperley JF, 2012, "Stem cell transplantation: Its importance today": Chronic myeloid leukaemia: Stem cell transplantation versus new drugs, Memo - Magazine of European Medical Oncology, Vol: 5, Pages: 277-280, ISSN: 1865-5041

Allogeneic stem cell transplantation (SCT) had traditionally been the first-line therapy of chronic myeloid leukaemia (CML), but the introduction of tyrosine kinase inhibitors (TKI) has caused a major change to the treatment algorithm. The majority of patients in chronic phase obtain an excellent response to these oral agents with minimal toxicity. SCT is therefore used only in a minority of patients who do not achieve adequate response to first-, second- or even third-generation agents. Patients in accelerated phase are less likely to achieve an optimal response and for patients in blast phase, SCT continues to be the only therapy with curative potential although it is now increasingly used in combination with TKI. This review discusses the place of SCT in the current therapy of CML. © 2012 Springer-Verlag Wien.

Journal article

Garnett C, Giles C, Ahmed O, Lasa M, Auner HW, MacDonald D, Marks S, Marin D, Milojkovic D, Pavlu J, Bua M, Abdalla S, Kanfer EJ, Apperley J, Rahemtulla Aet al., 2012, Tandem Autologous Stem Cell Transplantation in Chemorefractory Multiple Myeloma, 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

Conference paper

Garnett C, Giles C, Lasa M, Ahmed O, Bua M, Auner HW, MacDonald D, Marks S, Marin D, Milojkovic D, Pavlu J, Abdalla S, Kanfer EJ, Apperley J, Rahemtulla Aet al., 2012, Third Autologous Stem Cell Transplantation for Relapsed Multiple Myeloma, 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

Conference paper

Tharmalingam H, Naresh K, Bain BJ, Pavlu Jet al., 2012, Hypoplastic presentation of acute lymphoblastic leukemia, AMERICAN JOURNAL OF HEMATOLOGY, Vol: 87, Pages: 702-702, ISSN: 0361-8609

Journal article

Chaidos A, Patterson S, Szydlo R, Chaudhry MS, Dazzi F, Kanfer E, McDonald D, Marin D, Milojkovic D, Pavlu J, Davis J, Rahemtulla A, Rezvani K, Goldman J, Roberts I, Apperley J, Karadimitris Aet al., 2012, Graft invariant natural killer T-cell dose predicts risk of acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation, BLOOD, Vol: 119, Pages: 5030-5036, ISSN: 0006-4971

Journal article

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