Imperial College London

Jiri Pavlu

Faculty of MedicineDepartment of Immunology and Inflammation

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 8117j.pavlu Website

 
 
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Location

 

Leuka Building R2.20Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

122 results found

Garland P, de Lavallade H, Sekine T, Stringaris K, Loucaides E, Howe K, Kanfer E, Marin D, Apperley J, Milojkovic D, Macdonald D, Rahemtulla A, Pavlu J, Gabriel I, Khoder A, Alsuliman A, Bazeos A, Szydlo R, Cooper N, Rezvani Ket al., 2010, Severe 2009 H1N1 influenza in patients with haematological malignancies, 50th Annual Scientific Meeting of the British-Society-for-Haematology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 47-47, ISSN: 0007-1048

Conference paper

Porkka K, Pavlu J, Contento A, Mustjoki S, Olavarria E, Apperley Jet al., 2010, Tyrosine kinase inhibitor therapy is associated with a low risk of cytomegalovirus reactivation after allogeneic haematopoietic stem cell transplantation, 36th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantat/9th Meeting of the EBMT Data-Management-Group/26th Meeting of the EBMT Nurses Group/2nd EBMT Qual Management Meeting, Publisher: NATURE PUBLISHING GROUP, Pages: S38-S38, ISSN: 0268-3369

Conference paper

Auner H, Mazzarella L, Cook L, Szydlo R, Saltarelli F, Pavlu J, Chaidos A, McLornan D, Giles C, Bua M, Apperley J, Rahemtulla Aet al., 2010, High rate of stem cell mobilization failure after thalidomide and cyclophosphamide induction therapy for myeloma, BONE MARROW TRANSPLANTATION, Vol: 45, Pages: S21-S21, ISSN: 0268-3369

Journal article

Pavlu J, Auner H, Ellis S, Szydlo R, Giles C, McLornan D, Contento A, Rahemtulla A, Apperley J, Naresh K, MacDonald D, Kanfer Eet al., 2010, LACE-conditioned autologous stem cell transplantation for relapsed or refractory diffuse large B-cell lymphoma: treatment outcome and risk factor analysis from a single centre, BONE MARROW TRANSPLANTATION, Vol: 45, Pages: S255-S255, ISSN: 0268-3369

Journal article

Pavlu J, Kew A, Taylor-Roberts B, Auner H, Kanfer E, MacDonald D, Marin D, Milojkovic D, Rahemtulla A, Rezvani K, Goldman J, Apperley J, Szydlo Ret al., 2010, Optimizing patient selection for myeloablative allogeneic haemopoietic cell transplantation in chronic myeloid leukaemia in chronic phase, 36th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantat/9th Meeting of the EBMT Data-Management-Group/26th Meeting of the EBMT Nurses Group/2nd EBMT Qual Management Meeting, Publisher: NATURE PUBLISHING GROUP, Pages: S239-S239, ISSN: 0268-3369

Conference paper

Khalique Z, Pavlu J, Lefroy D, Layton Met al., 2010, Erythrocytapheresis in the prevention of recurrent myocardial infarction in sickle cell disease, AMERICAN JOURNAL OF HEMATOLOGY, Vol: 85, Pages: 91-91, ISSN: 0361-8609

Journal article

Pavlu J, Marin D, 2009, Dasatinib and Chronic Myeloid Leukemia: Two-Year Follow-up in Eight Clinical Trials, CLINICAL LYMPHOMA & MYELOMA, Vol: 9, Pages: 417-424, ISSN: 1557-9190

Journal article

Chaidos A, Giles C, Auner HW, Bua M, Pavlu J, Smith E, Kanfer E, MacDonald D, Apperley JF, Rahemtulla Aet al., 2009, Second Autologous Stem Cell Transplantation Is Effective Salvage Therapy for Relapsed Multiple Myeloma, 51st Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, Pages: 507-507, ISSN: 0006-4971

Conference paper

Auner HW, Owiti H, Giles C, Pavlu J, MacDonald D, Kanfer E, Apperley JF, Rahemtulla Aet al., 2009, Ethnic Disparity in Access to Stem Cell Transplantation for Multiple Myeloma., 51st Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, Pages: 708-709, ISSN: 0006-4971

Conference paper

Pavlu J, Kew A, Taylor-Roberts B, Auner H, Goldman J, Apperley J, Szydlo Ret al., 2009, Optimizing Patient Selection for Allogeneic Stem Cell Transplantation in Chronic Myeloid Leukemia, 51st Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, Pages: 1317-1317, ISSN: 0006-4971

Conference paper

Auner HW, Mazzarella L, Cook L, Szydlo R, Saltarelli F, Pavlu J, Apperley JF, Rahemtulla Aet al., 2009, The Combination of Cyclophosphamide and Thalidomide During Induction Therapy for Multiple Myeloma Results in a High Rate of Stem Cell Mobilization Failure, 51st Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, Pages: 844-844, ISSN: 0006-4971

Conference paper

Auner H, Giles C, Pavlu J, Olavarria E, Macdonald D, Kanfer E, Apperley J, Rahemtulla Aet al., 2009, Ethnicity and autologous stem cell transplantation in myeloma, 35th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation, Publisher: NATURE PUBLISHING GROUP, Pages: S148-S148, ISSN: 0268-3369

Conference paper

Pavlu J, Auner H, Szydlo R, Olavarria E, Giles C, Klammer M, Kew A, Milojkovic D, Gabriel I, Rezvani K, Dazzi F, Marin D, Goldman J, Apperley Jet al., 2009, Allogeneic myeloablative haematopoietic stem cell transplantation for chronic myeloid leukaemia in the imatinib era, 35th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation, Publisher: NATURE PUBLISHING GROUP, Pages: S49-S49, ISSN: 0268-3369

Conference paper

Auner HW, Giles C, Pavlu J, Macdonald D, Kanfer E, Olavarria E, Apperley J, Rahemtulla Aet al., 2009, Ethnicity and Myeloma: Experience of a Large UK Stem Cell Transplantation Center, Publisher: CIG MEDIA GROUP, LP, Pages: S84-S84, ISSN: 1557-9190

Conference paper

Bayley J, Pavlů J, Thompson M, 2009, Striking bone marrow plasmacytosis in a patient with sickle cell anaemia., Br J Haematol, Vol: 144

Journal article

Marin D, Milojkovic D, Olavarria E, Khorashad JS, de lavallade H, Reid AG, Foroni L, Rezvani K, Bua M, Dazzi F, Pavlu J, Klammer M, Kaeda JS, Goldman JM, Apperley JFet al., 2008, European LeukemiaNet criteria for failure or suboptimal response reliably identify patients with CML in early chronic phase treated with imatinib whose eventual outcome is poor, BLOOD, Vol: 112, Pages: 4437-4444, ISSN: 0006-4971

Journal article

Klammer M, Giles C, Reid AG, Ross FM, Szydlo RM, Pavlu J, Apperley JF, Rahemtulla Aet al., 2008, Incorporating Marrow Plasma Cell Infiltration at Diagnosis and Cytogenetic Features into Prognostic Scoring at Point of Autologous Stem Cell Transplantation for Multiple Myeloma, 50th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, Pages: 1140-1140, ISSN: 0006-4971

Conference paper

Pavlu J, Klammer M, Gabriel I, Szydlo R, Olavarria E, Milojkovic D, Kew A, Rezvani K, Dazzi F, Marin D, Goldman J, Apperley Jet al., 2008, Allogeneic Myeloablative Hematopoietic Stem Cell Transplantation for Chronic Myelogenous Leukemia in the Imatinib Era., 50th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, Pages: 357-357, ISSN: 0006-4971

Conference paper

Milojkovic D, Bua M, Apperley JF, Kozlowski K, Sorori J, Foroni L, Reid A, Pavlu J, Rezvani K, Dazzi F, Olavarria E, Klammer M, Goldman JM, Marin Det al., 2008, Prediction of Cytogenetic Response to Second Generation TKI Therapy in CML Chronic Phase Patients Who Have Failed Imatinib Therapy and Early Identification of Factors That Influence Survival, 50th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, Pages: 129-129, ISSN: 0006-4971

Conference paper

Pavlu J, Andreasson C, Chuah C, Kaeda J, Goldman JM, Apperley JF, Marin Det al., 2007, Dual inhibition of ras and bcr-abl signalling pathways in chronic myeloid leukaemia: a phase I/II study in patients in complete haematological remission, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 137, Pages: 423-428, ISSN: 0007-1048

Journal article

Pavlu J, Babb A, 2007, Pneumococcal septicaemia, LANCET INFECTIOUS DISEASES, Vol: 7, Pages: 234-234, ISSN: 1473-3099

Journal article

Pavlu J, Ahmed RE, O'Regan DP, Partridge J, Lefroy DC, Layton DMet al., 2007, Myocardial infarction in sickle-cell disease, LANCET, Vol: 369, Pages: 246-246, ISSN: 0140-6736

Journal article

Pavlu J, Jackson M, Panoskaltsis N, 2006, GM1-gangliosidosis type I., Br J Haematol, Vol: 135, ISSN: 0007-1048

Journal article

Pavlu J, Carey MP, Winer JB, 2006, Hypothyroidism and nemaline myopathy in an adult, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 77, Pages: 708-709, ISSN: 0022-3050

Journal article

Pavlu J, Jan-Mohamed R, Kaczmarski R, 2006, Pathological odontoid fracture., Lancet Oncol, Vol: 7, ISSN: 1470-2045

Journal article

, 2005, Dysplastic polychromatic "snowblast"., Blood, Vol: 106, ISSN: 0006-4971

Journal article

Varga Z, Pavlu J, 2005, Roth's spots, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 353, Pages: 1041-1041, ISSN: 0028-4793

Journal article

Pavlu J, Harrington DJ, Voong K, Savidge GF, Jan-Mohamed R, Kaczmarski Ret al., 2005, Superwarfarin poisoning., Lancet, Vol: 365

Journal article

Pavlu J, Czepulkowski B, Kaczmarski R, Jan-Mohamed Ret al., 2005, Early blastic transformation with CNS infiltration in a patient with chronic myeloid leukaemia treated with imatinib, LANCET ONCOLOGY, Vol: 6, Pages: 128-128, ISSN: 1470-2045

Journal article

Pavlů J, Necas E, 1998, [Paroxysmal nocturnal hemoglobinuria and its association with aplastic anemia]., Cas Lek Cesk, Vol: 137, Pages: 419-423, ISSN: 0008-7335

Paroxysmal nocturnal haemoglobinuria (PNH) is an acquired clonal disorder of haematopoiesis. Clinically it is characterized by intravascular haemolysis, venous thrombosis and often by bone marrow hypoplasia. Haemolysis and thrombosis develop as a consequence of deficiency of several proteins on the cell membrane of the affected clone of blood elements. This is caused by somatic mutations in the PIG-A gene, which encodes an enzyme involved in the biosynthesis of glycosylphosphatidylinositol (GPI) anchor. Spectrum of mutations in the PIG-A gene is different to that observed in other genes. The mutations are mainly small deletions and insertions causing frameshift; large deletions are rare. Recently, however, a 88 base pairs direct tandem repeat insertion has been reported in a patient with PNH developed on the background of aplastic anaemia (AA). The peculiar pattern of the PIG-A gene mutations and the finding that more than one mutated clone is commonly present in patients with PNH might suggest that some form of hypermutability, caused by decreased DNA stability, deficient repair or increased generation of mutagens, might underline PNH. As most mutations cause cell death, it would explain the hypoplastic nature of the disorder and its association with AA. Other models of pathogenesis of PNH are also discussed.

Journal article

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