Imperial College London

Jiri Pavlu

Faculty of MedicineDepartment of Immunology and Inflammation

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 8117j.pavlu Website

 
 
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Location

 

Leuka Building R2.20Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

133 results found

Deplano S, May PC, Pavlu J, 2013, Double minutes with MYC amplification in a patient with chronic myelomonocytic leukaemia transformed into acute myeloid leukaemia, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 162, Pages: 720-720, ISSN: 0007-1048

Journal article

Iskander D, Apperley JF, Pavlu J, 2013, Stem cell transplantation and high-dose chemotherapy, Advances in the Treatment of Chronic Myeloid Leukemia, Pages: 63-76, ISBN: 9781780842752

Book chapter

Auner HW, Szydlo R, Rone A, Giles C, Chaidos A, Kanfer EJ, Macdonald DH, Milojkovic D, Marin D, Pavlu J, Apperley JF, Rahemtulla Aet al., 2013, Salvage autologous stem cell transplantation for multiple myeloma relapsing or progressing after up-front autologous transplantation, BONE MARROW TRANSPLANTATION, Vol: 48, Pages: S199-S199, ISSN: 0268-3369

Journal article

Mactier CE, Beckerson J, Palanicawandar R, Lasa M, Szydlo RM, Slade D, Marin D, Milojkovic D, Kanfer EJ, Rahemtulla A, Apperley JF, Pavlu Jet al., 2013, Enteral-based nutrition is associated with better early outcomes in allogeneic myeloablative haematopoietic stem cell transplantation, 39th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S347-S347, ISSN: 0268-3369

Conference paper

Gabriel IH, Sergeant R, Szydlo R, Apperley JF, Alsuliman A, Khoder A, Goldman J, Kanfer E, de Lavallade H, Miljokovic D, Rahemtulla A, Pavlu J, Foroni L, Marin D, Rezvani Ket al., 2013, Donor KIR2DS2/DL2 genotype status is associated with an increased incidence of severe acute graft-versus-host disease following myeloablative haematopoeitic stem cell transplantation, 39th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S19-S19, ISSN: 0268-3369

Conference paper

Rotolo A, Pavlu J, Davidson H, Lasa M, Palanicawandar R, Giles C, MacDonald D, Marin D, Milojkovic D, Rahemtulla A, Apperley J, Kanfer Eet al., 2013, LACE reduced intensity conditioning for high-risk haematological malignancies: a 22-year single-centre experience, 39th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S235-S235, ISSN: 0268-3369

Conference paper

Innes AJ, Lurkins J, Szydlo R, Foroni L, Milojkovic D, Pavlu J, Marin D, Kanfer E, MacDonald D, Rahemtulla A, Loaiza S, Kirschke S, Rezvani K, Goldman J, Apperley J, Dazzi Fet al., 2013, Long-term leukaemia control following DLI is independent of disease eradication, 39th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S251-S251, ISSN: 0268-3369

Conference paper

Innes AJ, Beattie R, Sergeant R, Ghandi D, Foroni L, Marin D, Kanfer E, Mielke S, Milojkovic D, MacDonald D, Pavlu J, Rahemtulla A, Roberts I, Slade D, Bray E, Goldman J, Apperley J, Szydlo R, Dazzi F, Rezvani Ket al., 2013, HLA-mismatched donor lymphocyte infusion is safe for the treatment of leukaemia relapse following alemtuzumab-based myeloablative allogeneic stem cell transplantation, 39th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S86-S87, ISSN: 0268-3369

Conference paper

Pavlu J, Apperley JF, 2013, Allogeneic Stem Cell Transplantation for Chronic Myeloid Leukemia, CURRENT HEMATOLOGIC MALIGNANCY REPORTS, Vol: 8, Pages: 43-51, ISSN: 1558-8211

Journal article

Neave EL, Schwarb H, Shlebak A, Layton DM, Apperley JF, Pavlu Jet al., 2013, Lymphodepletion chemotherapy followed by donor leukocytes for post-transplantation relapse of myelofibrosis after previous donor leukocyte infusion failure, EUROPEAN JOURNAL OF HAEMATOLOGY, Vol: 90, Pages: 76-78, ISSN: 0902-4441

Journal article

Pavlu J, Chakrabartty J, Apperley JF, 2012, "Stem cell transplantation: Its importance today": Chronic myeloid leukaemia: Stem cell transplantation versus new drugs, Memo - Magazine of European Medical Oncology, Vol: 5, Pages: 277-280, ISSN: 1865-5041

Allogeneic stem cell transplantation (SCT) had traditionally been the first-line therapy of chronic myeloid leukaemia (CML), but the introduction of tyrosine kinase inhibitors (TKI) has caused a major change to the treatment algorithm. The majority of patients in chronic phase obtain an excellent response to these oral agents with minimal toxicity. SCT is therefore used only in a minority of patients who do not achieve adequate response to first-, second- or even third-generation agents. Patients in accelerated phase are less likely to achieve an optimal response and for patients in blast phase, SCT continues to be the only therapy with curative potential although it is now increasingly used in combination with TKI. This review discusses the place of SCT in the current therapy of CML. © 2012 Springer-Verlag Wien.

Journal article

Garnett C, Giles C, Ahmed O, Lasa M, Auner HW, MacDonald D, Marks S, Marin D, Milojkovic D, Pavlu J, Bua M, Abdalla S, Kanfer EJ, Apperley J, Rahemtulla Aet al., 2012, Tandem Autologous Stem Cell Transplantation in Chemorefractory Multiple Myeloma, 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

Conference paper

Garnett C, Giles C, Lasa M, Ahmed O, Bua M, Auner HW, MacDonald D, Marks S, Marin D, Milojkovic D, Pavlu J, Abdalla S, Kanfer EJ, Apperley J, Rahemtulla Aet al., 2012, Third Autologous Stem Cell Transplantation for Relapsed Multiple Myeloma, 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

Conference paper

Tharmalingam H, Naresh K, Bain BJ, Pavlu Jet al., 2012, Hypoplastic presentation of acute lymphoblastic leukemia, AMERICAN JOURNAL OF HEMATOLOGY, Vol: 87, Pages: 702-702, ISSN: 0361-8609

Journal article

Chaidos A, Patterson S, Szydlo R, Chaudhry MS, Dazzi F, Kanfer E, McDonald D, Marin D, Milojkovic D, Pavlu J, Davis J, Rahemtulla A, Rezvani K, Goldman J, Roberts I, Apperley J, Karadimitris Aet al., 2012, Graft invariant natural killer T-cell dose predicts risk of acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation, BLOOD, Vol: 119, Pages: 5030-5036, ISSN: 0006-4971

Journal article

Kishore B, Davis J, Rezvani K, Marin D, Chakrabartty J, Szydlo R, Loazia S, Chaidos A, Giles C, Kanfer E, Karadimitris A, Macdonald D, Milojkovic D, Rahemtulla A, Goldman J, Apperley J, Pavlu Jet al., 2012, Cryopreserved allogeneic peripheral blood stem cells result in outcome equivalent to those of fresh infusions enabling rational scheduling of donations, 38th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S253-S254, ISSN: 0268-3369

Conference paper

Chakrabartty J, Pavlu J, Neave EL, Eguialde ML, O'Shea D, Giles C, Goldman J, Kirschke S, Kanfer E, Kishore B, MacDonald D, Milojkovic D, Marin D, Rahemtulla A, Olavarria E, Apperley J, Rezvani Ket al., 2012, Safety and efficacy of two regimens of high-dose liposomal amphotericin B for prophylaxis of invasive fungal infection in allogeneic haematopoietic stem cell transplantation: a comparative retrospective single-centre study, 38th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S131-S131, ISSN: 0268-3369

Conference paper

Beckerson J, Sampson B, Kanfer E, Marin D, Milojkovic D, Pavlu J, Rahemtulla A, Rezvani K, Apperley J, Taylor Aet al., 2012, Plasma zinc, copper and selenium in subjects planned for haematopoietic stem cell transplant and their change during treatment, 38th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S192-S192, ISSN: 0268-3369

Conference paper

Pavlu J, Rezvani K, Kishore B, Chakrabartty J, Shah R, Auner HW, Milojkovic D, Marin D, Rahemtulla A, MacDonald DH, Kanfer EJ, Dazzi F, Goldman JM, Apperley JF, Szydlo RMet al., 2012, Optimising patient selection for allogeneic stem cell transplantation: prediction of non-relapse mortality and survival, 38th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S27-S28, ISSN: 0268-3369

Conference paper

Innes A, May PC, Pavlu J, Bain BJet al., 2012, Unexpected pancytopenia following treatment of acute lymphoblastic leukemia, AMERICAN JOURNAL OF HEMATOLOGY, Vol: 87, Pages: 412-412, ISSN: 0361-8609

Journal article

Auner HW, Pavlu J, Szydlo R, Giles C, Kanfer E, Macdonald D, Marin D, Milojkovic D, Rezvani K, Goldman JM, Apperley JF, Landgren O, Rahemtulla Aet al., 2012, Autologous haematopoietic stem cell transplantation in multiple myeloma patients from ethnic minority groups in an equal access healthcare system, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 157, Pages: 125-127, ISSN: 0007-1048

Journal article

Rezvani K, Kanfer EJ, Marin D, Gabriel I, Rahemtulla A, Taylor A, MacDonald D, Dazzi F, Milojkovic D, Foroni L, Pavlu J, Sargent J, Le Dieu R, Goldman JM, Apperley J, Szydlo Ret al., 2012, EBMT Risk Score Predicts Outcome of Allogeneic Hematopoietic Stem Cell Transplantation in Patients Who Have Failed a Previous Transplantation Procedure, BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, Vol: 18, Pages: 235-240, ISSN: 1083-8791

Journal article

Al-Shieban S, Liu C, Fishlock K, May PC, Pavlu J, Naresh KNet al., 2012, Bone marrow trephine biopsy findings in acute promyelocytic leukemia., Am J Hematol, Vol: 87, Pages: 109-110

Journal article

Pavlu J, Rezvani K, Kishore B, Le Dieu R, Chakrabartty J, Chaidos A, Kanfer EJ, Karadimitris A, MacDonald DH, Marin D, Milojkovic D, O'Boyle F, Rahemtulla A, Slade D, Goldman JM, Apperley JF, Szydlo RMet al., 2011, Elevated Preconditioning Serum Levels of C-Reactive Protein Are Associated with Increased Nonrelapse Mortality and Inferior Survival After Reduced Intensity Allogeneic Hematopoietic Stem Cell Transplantation, 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, Publisher: AMER SOC HEMATOLOGY, Pages: 849-849, ISSN: 0006-4971

Conference paper

Kishore B, Davis J, Rezvani K, Marin D, Szydlo RM, Sandra L, Chrissy G, Chaidos A, Kanfer EJ, Karadimitris A, MacDonald DH, Milojkovic D, Rahemtulla A, Goldman JM, Apperley JF, Pavlu Jet al., 2011, Cryopreserved Allogeneic Peripheral Blood Stem Cells Result in Outcome Equivalent to Those of Fresh Infusions Enabling Rational Scheduling of Donations, 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, Publisher: AMER SOC HEMATOLOGY, Pages: 1730-1731, ISSN: 0006-4971

Conference paper

Innes AJ, Lurkins J, Szydlo RM, Guerra A, Milojkovic D, Pavlu J, Kanfer EJ, Marin D, MacDonald D, Rahemtulla A, Loaiza S, Kirschke S, Rezvani K, Goldman J, Apperley JF, Dazzi Fet al., 2011, The Majority of Patients Receiving Donor Lymphocyte Infusions for Relapsed Chronic Myeloid Leukemia Remain PCR Positive Despite Maintaining Long-Term Remission, 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, Publisher: AMER SOC HEMATOLOGY, Pages: 1752-1752, ISSN: 0006-4971

Conference paper

Pavlu J, Auner HW, Ellis S, Szydlo RM, Giles C, Contento A, Rahemtulla A, Apperley JF, Naresh K, MacDonald DH, Kanfer EJet al., 2011, LACE-conditioned autologous stem cell transplantation for relapsed or refractory diffuse large B-cell lymphoma: treatment outcome and risk factor analysis from a single centre, HEMATOLOGICAL ONCOLOGY, Vol: 29, Pages: 75-80, ISSN: 0278-0232

Journal article

Pavlu J, Emmerson J, Marks AJ, Bain BJet al., 2011, Idiopathic cytopenia of undetermined significance and the minimal criteria for a diagnosis of myelodysplastic syndrome, LEUKEMIA & LYMPHOMA, Vol: 52, Pages: 515-516, ISSN: 1042-8194

Journal article

de Lavallade H, Garland P, Sekine T, Hoschler K, Marin D, Stringaris K, Loucaides E, Howe K, Szydlo R, Kanfer E, Macdonald D, Kelleher P, Cooper N, Khoder A, Gabriel IH, Milojkovic D, Pavlu J, Goldman JM, Apperley JF, Rezvani Ket al., 2011, Repeated vaccination is required to optimize seroprotection against H1N1 in the immunocompromised host, HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, Vol: 96, Pages: 307-314, ISSN: 0390-6078

Journal article

de Lavallade H, Garland P, Sekine T, Hoschler K, Marin D, Stringaris K, Loucaides E, Howe K, Szydlo R, Kanfer E, Macdonald D, Kelleher P, Cooper N, Khoder A, Gabriel IH, Milojkovic D, Pavlu J, Goldman JM, Apperley JF, Rezvani Ket al., 2011, Repeated vaccination is required to optimize seroprotection against H1N1 in the immunocompromised host., Haematologica, Vol: 96, Pages: 307-314

BACKGROUND: In 2009 the declaration by the World Health Organization of a global pandemic of influenza-H1N1 virus led to a vaccination campaign to ensure protection for immunocompromised patients. The goal of this study was to determine the efficacy of the 2009 H1N1 vaccine in patients with hematologic malignancies. DESIGN AND METHODS: We evaluated humoral and cellular immune responses to 2009 H1N1 vaccine in 97 adults with hematologic malignancies and compared these responses with those in 25 adult controls. Patients received two injections of vaccine 21 days apart and the controls received one dose. Antibody titers were measured using a hemagglutination-inhibition assay on days 0, 21 and 49 after injection of the first dose. Cellular immune responses to H1N1 were determined on days 0 and 49. RESULTS: By day 21 post-vaccination, protective antibody titers of 1:32 or more were seen in 100% of controls compared to 39% of patients with B-cell malignancies (P<0.001), 46% of allogeneic stem cell transplant recipients (P<0.001) and 85% of patients with chronic myeloid leukemia (P=0.086). After a second dose, seroprotection rates increased to 68%, (P=0.008), 73%, (P=0.031), and 95% (P=0.5) in patients with B-cell malignancies, after allogeneic stem cell transplantation and with chronic myeloid leukemia, respectively. On the other hand, T-cell responses to H1N1 vaccine were not significantly different between patients and controls. CONCLUSIONS: These data demonstrate the efficacy of H1N1 vaccine in most patients with hematologic malignancies and support the recommendation for the administration of two doses of vaccine in immunocompromised patients. These results may contribute towards the development of evidence-based guidelines for influenza vaccination in such patients in the future.

Journal article

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