Imperial College London

Jiri Pavlu

Faculty of MedicineDepartment of Immunology and Inflammation

Honorary Clinical Senior Lecturer
 
 
 
//

Contact

 

+44 (0)20 3313 8117j.pavlu Website

 
 
//

Location

 

Leuka Building R2.20Hammersmith HospitalHammersmith Campus

//

Summary

 

Publications

Publication Type
Year
to

133 results found

Pavlu J, Andreasson C, Chuah C, Kaeda J, Goldman JM, Apperley JF, Marin Det al., 2007, Dual inhibition of ras and bcr-abl signalling pathways in chronic myeloid leukaemia: a phase I/II study in patients in complete haematological remission, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 137, Pages: 423-428, ISSN: 0007-1048

Journal article

Pavlu J, Babb A, 2007, Pneumococcal septicaemia, LANCET INFECTIOUS DISEASES, Vol: 7, Pages: 234-234, ISSN: 1473-3099

Journal article

Pavlu J, Ahmed RE, O'Regan DP, Partridge J, Lefroy DC, Layton DMet al., 2007, Myocardial infarction in sickle-cell disease, LANCET, Vol: 369, Pages: 246-246, ISSN: 0140-6736

Journal article

Pavlu J, Jackson M, Panoskaltsis N, 2006, GM1-gangliosidosis type I., Br J Haematol, Vol: 135, ISSN: 0007-1048

Journal article

Pavlu J, Carey MP, Winer JB, 2006, Hypothyroidism and nemaline myopathy in an adult, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 77, Pages: 708-709, ISSN: 0022-3050

Journal article

Pavlu J, Jan-Mohamed R, Kaczmarski R, 2006, Pathological odontoid fracture., Lancet Oncol, Vol: 7, ISSN: 1470-2045

Journal article

, 2005, Dysplastic polychromatic "snowblast"., Blood, Vol: 106, ISSN: 0006-4971

Journal article

Varga Z, Pavlu J, 2005, Roth's spots, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 353, Pages: 1041-1041, ISSN: 0028-4793

Journal article

Pavlu J, Harrington DJ, Voong K, Savidge GF, Jan-Mohamed R, Kaczmarski Ret al., 2005, Superwarfarin poisoning., Lancet, Vol: 365

Journal article

Pavlu J, Czepulkowski B, Kaczmarski R, Jan-Mohamed Ret al., 2005, Early blastic transformation with CNS infiltration in a patient with chronic myeloid leukaemia treated with imatinib, LANCET ONCOLOGY, Vol: 6, Pages: 128-128, ISSN: 1470-2045

Journal article

Pavlů J, Necas E, 1998, [Paroxysmal nocturnal hemoglobinuria and its association with aplastic anemia]., Cas Lek Cesk, Vol: 137, Pages: 419-423, ISSN: 0008-7335

Paroxysmal nocturnal haemoglobinuria (PNH) is an acquired clonal disorder of haematopoiesis. Clinically it is characterized by intravascular haemolysis, venous thrombosis and often by bone marrow hypoplasia. Haemolysis and thrombosis develop as a consequence of deficiency of several proteins on the cell membrane of the affected clone of blood elements. This is caused by somatic mutations in the PIG-A gene, which encodes an enzyme involved in the biosynthesis of glycosylphosphatidylinositol (GPI) anchor. Spectrum of mutations in the PIG-A gene is different to that observed in other genes. The mutations are mainly small deletions and insertions causing frameshift; large deletions are rare. Recently, however, a 88 base pairs direct tandem repeat insertion has been reported in a patient with PNH developed on the background of aplastic anaemia (AA). The peculiar pattern of the PIG-A gene mutations and the finding that more than one mutated clone is commonly present in patients with PNH might suggest that some form of hypermutability, caused by decreased DNA stability, deficient repair or increased generation of mutagens, might underline PNH. As most mutations cause cell death, it would explain the hypoplastic nature of the disorder and its association with AA. Other models of pathogenesis of PNH are also discussed.

Journal article

Mortazavi Y, Pavlu J, Harsh JCW, Gordon-Smith EC, Rutherford TRet al., 1998, Distinctive and multiple mutations of the PIG-A gene in aplastic anaemia paroxysmal nocturnal haemoglobinuria, Publisher: BLACKWELL SCIENCE LTD, Pages: 11-11, ISSN: 0007-1048

Conference paper

Pavlu J, Mortazavi Y, Tooze J, Marsh JCW, GordonSmith EC, Rutherford TRet al., 1997, Paroxysmal nocturnal haemoglobinuria due to an 88 bp direct tandem repeat insertion in the PIG-A gene, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 98, Pages: 289-291, ISSN: 0007-1048

Journal article

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wlsprd.imperial.ac.uk:80/respub/WEB-INF/jsp/search-html.jsp Request URI: /respub/WEB-INF/jsp/search-html.jsp Query String: id=00618900&limit=30&person=true&page=5&respub-action=search.html