Imperial College London

Jiri Pavlu

Faculty of MedicineDepartment of Immunology and Inflammation

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 8117j.pavlu Website

 
 
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Location

 

Leuka Building R2.20Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pello:2017:10.1111/ejh.12848,
author = {Pello, OM and Innes, AJ and Bradshaw, A and Finn, S-A and Uddin, S and Bray, E and Olavarria, E and Apperley, JF and Pavlu, J},
doi = {10.1111/ejh.12848},
journal = {EUROPEAN JOURNAL OF HAEMATOLOGY},
pages = {632--634},
title = {BKV-specific T cells in the treatment of severe refractory haemorrhagic cystitis after HLA-haploidentical haematopoietic cell transplantation},
url = {http://dx.doi.org/10.1111/ejh.12848},
volume = {98},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Background:Haemorrhagic cystitis caused by BK virus (BKV) is a known complication of allogeneic haematopoietic cell transplantation (HCT) and is relatively common following HLA-haploidentical transplantation. Adoptive immunotransfer of virus-specific T cells from the donor is a promising therapeutic approach, although production of these cells is challenging, particularly when dealing with low-frequency T cells such as BKV-specific T cells.Case report:Here, we present a patient who, following haploidentical HCT, developed severe BKV haemorrhagic cystitis, resistant to standard therapy. He responded well to adoptive transfer of donor cells enriched in BKV-specific T cells using the new second-generation CliniMACS Prodigy and the Cytokine Capture System from Miltenyi Biotec. Treatment led to full resolution of both the symptoms and viraemia without unwanted complications.Conclusion:Our observations suggest that use of products enriched with BKV-specific T cells generated using this system is safe and efficient in HLA-haploidentical HCT where BKV cystitis can be a serious complication.
AU - Pello,OM
AU - Innes,AJ
AU - Bradshaw,A
AU - Finn,S-A
AU - Uddin,S
AU - Bray,E
AU - Olavarria,E
AU - Apperley,JF
AU - Pavlu,J
DO - 10.1111/ejh.12848
EP - 634
PY - 2017///
SN - 0902-4441
SP - 632
TI - BKV-specific T cells in the treatment of severe refractory haemorrhagic cystitis after HLA-haploidentical haematopoietic cell transplantation
T2 - EUROPEAN JOURNAL OF HAEMATOLOGY
UR - http://dx.doi.org/10.1111/ejh.12848
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000403724100013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - http://hdl.handle.net/10044/1/49330
VL - 98
ER -