Imperial College London

Jiri Pavlu

Faculty of MedicineDepartment of Medicine

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 8117j.pavlu Website

 
 
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Location

 

Leuka Building R2.20Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

118 results found

Innes A, Wooley P, Szydlo R, Lozano S, Fernando F, Bansal D, Palanicawandar R, Milojkovic D, May P, Nadal-Melsio E, Yebra-Fernandez E, Olavarria E, Apperley J, Pavlu Jet al., Complete remission with incomplete count recovery (CRi) prior to allogeneic HCT for acute myeloid leukaemia is associated with a high non-relapse mortality., Leukemia, ISSN: 1476-5551

Journal article

Beckerson J, Szydlo RM, Hickson M, Mactier CE, Innes AJ, Gabriel IH, Palanicawandar R, Kanfer EJ, Macdonald DH, Milojkovic D, Rahemtulla A, Chaidos A, Karadimitris A, Olavarria E, Apperley JF, Pavlu Jet al., 2019, Impact of route and adequacy of nutritional intake on outcomes of allogeneic haematopoietic cell transplantation for haematologic malignancies, Clinical Nutrition, Vol: 38, Pages: 738-744, ISSN: 0261-5614

BACKGROUND: Allogeneic haematopoietic cell transplantation (HCT) is often associated with poor oral intake due to painful mucositis and gastrointestinal sequalae that occur following a preparative regimen of intensive chemotherapy and/or total body radiation. Although attractive to assume that optimal nutrition improves HCT outcomes, there are limited data to support this. It is also unclear whether artificial nutrition support should be provided as enteral tube feeding or parenteral nutrition (PN). METHODS: We analysed day-100 non-relapse mortality (NRM), incidence of acute graft-versus-host disease (GvHD), acute gastrointestinal GvHD, 5-year survival and GvHD-free/relapse-free survival (GRFS) according to both route and adequacy of nutritional intake prior to neutrophil engraftment, together with other known prognostic factors, in a retrospective cohort of 484 patients who underwent allogeneic HCT for haematologic malignancy between 2000 and 2014. RESULTS: Multivariate analyses showed increased NRM with inadequate nutrition (hazard ratio (HR) 4.1; 95% confidence interval (CI) 2.2-7.2) and adequate PN (HR 2.9; 95% CI 1.6-5.4) compared to adequate enteral nutrition (EN) both P < .001. There were increased incidences of gastrointestinal GvHD of any stage and all GvHD ≥ grade 2 in patients who received PN (odds ratio (OR) 2.0; 95% CI 1.2-3.3; P = .006, and OR 1.8; 95% CI 1.1-3.0; P = .018, respectively), compared to adequate EN. Patients who received adequate PN and inadequate nutrition also had reduced probabilities of survival and GRFS at 5 years. CONCLUSION: Adequate EN during the early transplantation course is associated with reduced NRM, improved survival and GRFS at 5 years. Furthermore, adequate EN is associated with lower incidence of overall and gut acute GvHD than PN, perhaps because of its ability to maintain mucosal integrity, modulate the immune response to intensive chemo/radiotherapy and support the gastroi

Journal article

Bassan R, Hoelzer D, Thomas X, Montesinos P, Pavlu J, McKendrick J, Kudlac A, Barlev A, Barber B, Cong Zet al., 2019, Clinician Concepts of Cure in Adult Relapsed and Refractory Philadelphia-Negative B Cell Precursor Acute Lymphoblastic Leukemia: A Delphi Study, ADVANCES IN THERAPY, Vol: 36, Pages: 870-879, ISSN: 0741-238X

Journal article

Innes A, Woolley P, Szydlo R, Lozano S, Fernando F, Bansal D, Palanicawandar R, Milojkovic D, May P, Nadal-Melsio E, Yebra-Fernandez E, Olavarria E, Apperley J, Pavlu Jet al., 2019, Complete Remission with Incomplete Count Recovery (CRi) Prior to Allogeneic Haematopoietic Cell Transplantation for Acute Myeloid Leukaemia is Associated with a High Non-relapse Mortality without Increased Relapse Risk, 59th Annual Scientific Meeting of the British-Society-for-Hematology, Publisher: WILEY, Pages: 152-152, ISSN: 0007-1048

Conference paper

Aldiwani M, Tharakan T, Al-Hassani A, Gibbons N, Pavlu J, Hrouda Det al., 2019, BK Virus Associated Haemorrhagic Cystitis. A systematic review of current prevention and treatment strategies, INTERNATIONAL JOURNAL OF SURGERY, Vol: 63, Pages: 34-42, ISSN: 1743-9191

Journal article

Woolley P, Slade D, Syzdlo R, Nesr GN, Claudiani S, Caballes I, Fernando F, Pavlu J, Palani R, Kanfer E, Olavarria E, Milojkovic D, Apperley Jet al., 2018, 34-Year Single Center Observational Review of Ex-Vivo T-Cell Depleted Allogeneic Hematopoietic Stem Cell Transplants for Chronic Myeloid Leukemia, 60th Annual Meeting of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

Conference paper

Innes AJ, Woolley P, Szydlo R, Lozano S, Fernando F, Bansal D, Palanicawandar R, Nadal-Melsio E, Yebra-Fernandez E, Apperley J, Olavarria E, Pavlu Jet al., 2018, Complete remission with incomplete count recovery (CRi) prior to allogeneic hematopoietic cell transplantation for acute myeloid leukemia is associated with a high non-relapse mortality without increased relapse risk, 60th Annual Meeting of the American-Society-of-Hematology (ASH), Publisher: American Society of Hematology, ISSN: 1528-0020

Conference paper

Snober M, Syzdlo R, Apperley J, Chaidos A, Kanfer E, Milojkovic D, Olavarria E, Palanicawandar R, Pavlu J, Todd JF, Salooja Net al., 2018, Incidence and Risk Factors for Second Malignancies after Transplant in Long Term Survivors of Allogeneic Haematopoietic Stem Cell Transplant: A Single Centre Experience, 60th Annual Meeting of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

Conference paper

Ghani R, Mookerjee S, Mullish BH, Thursz M, Marchesi J, Pavlu J, Davies Fet al., 2018, Impact on Length of Stay and Antibiotic Use in Allogenic and Autologous Stem Cell Transplant Patients Colonized with Carbapenemase-producing Enterobacteriaceae, IDWeek, Publisher: Oxford University Press, ISSN: 2328-8957

Conference paper

Ainley L, Pavlu J, 2018, Ambulatory autologous stem cell transplantation for multiple myeloma and lymphoma: A single centre experience, 58th Annual Scientific Meeting of the British-Society-for-Haematology, Publisher: WILEY, Pages: 156-156, ISSN: 0007-1048

Conference paper

Craddock C, Tholouli E, Vicente SM, Gbandi E, Houlton AE, Drummond MW, Pavlu J, Vyas Pet al., 2017, Safety and Clinical Activity of Combined Romidepsin and Azacitidine Therapy in High Risk Acute Myeloid Leukemia: Preliminary Results of the Romaza Trial, 59th Annual Meeting of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

Conference paper

Innes AJ, Mullish BH, Fernando F, Adams G, Marchesi JR, Apperley JF, Brannigan E, Davies F, Pavlů Jet al., 2017, Faecal microbiota transplant: a novel biological approach to extensively drug-resistant organism-related non-relapse mortality., Bone Marrow Transplantation, Vol: 52, Pages: 1452-1454, ISSN: 1476-5365

Journal article

Monsalvo S, Sevillano B, Palanicawandar R, Innes A, Milojkovic D, Gabriel I, Szydlo R, Macdonald D, Chaidos A, Jakob C, Pavlu J, Stumpfle R, Skinner L, Kanfer E, Apperley JF, Olavarria Eet al., 2017, Changes in intensive care for stem cell transplant patients: the need for response criteria at 5 days of full treatment to separate good risk patients and avoid futile interventions, 43rd Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S278-S278, ISSN: 0268-3369

Conference paper

Pello OM, Bradshaw A, Innes A, Finn S-A, Uddin S, Bray E, Olavarria E, Apperley JF, Pavlu Jet al., 2017, Clinical efficacy of BK virus specific T-cells in treatment of severe refractory hemorrhagic cystitis after HLA haploidentical transplantation, 43rd Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S483-S484, ISSN: 0268-3369

Conference paper

Monsalvo S, Gabriel I, Sevillano B, Palanicawandar R, Innes A, Milojkovic D, Macdonald D, Chaidos A, Jakob C, Pavlu J, Nicholas R, Malik O, Kazmi M, Silber E, Kanfer E, Muraro P, Apperley JF, Olavarria Eet al., 2017, Exacerbation of multiple sclerosis symptoms in patients undergoing autologous stem cell transplantation, 43rd Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S419-S420, ISSN: 0268-3369

Conference paper

Khoder A, Palanicawandar R, Atta M, Selvaratnam V, Sever M, Pello OM, Loaiza S, Bray E, Bradshaw A, Uddin S, Chaidos A, Karadimitris A, Jacob C, MacDonald D, Milojkovic D, Pavlu J, Auner H, Szydlo R, Apperley JF, Olavarria E, Kanfer Eet al., 2017, The choice between stem cell mobilisation with GCSF alone or with GCSF plus chemotherapy may impact on the stem cell transplant service, 43rd Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S146-S147, ISSN: 0268-3369

Conference paper

Ghani L, Salooja N, Stuart J, Szydlo R, Apperley J, Chaidos A, Gabriel I, Jakob C, Kanfer E, Olavarria E, Macdonald D, Milojkovic D, Palanicawandar R, Pavlu J, Todd Jet al., 2017, Microalbuminuria in long-term survivors of hematopoietic cell transplant: a retrospective single-centre study, 43rd Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S300-S300, ISSN: 0268-3369

Conference paper

Sevillano B, Monsalvo S, Lozano S, Bailey C, Szydlo R, Gabriel I, Pavlu J, Milojkovic D, Palanicawandar R, Kanfer E, Olavarria E, Apperley Jet al., 2017, Ciclosporin toxicity: Increased mortality and incidence of chronic GvHD after stopping Ciclosporin A and replacing it with mycophenolate mofetil as prophylaxis for GvHD, 43rd Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S204-S205, ISSN: 0268-3369

Conference paper

Pavlu J, Auner H, Szydlo RM, Sevillano B, Palani R, O'Boyle F, Chaidos A, Jakob C, Kanfer E, MacDonald D, Milojkovic D, Rahemtulla A, Bradshaw A, Olavarria E, Apperley JF, Pello OMet al., 2017, Analysis of hematopoietic recovery after autologous transplantation as method of quality control for long-term progenitor cell cryopreservation., Bone Marrow Transplantation, Vol: 52, Pages: 1599-1601, ISSN: 1476-5365

Hematopoietic precursor cells (HPC) are able to restore hematopoiesis after high-dose chemotherapy and their cryopreservation is routinely employed prior to the autologous hematopoietic cell transplantation (AHCT). Although previous studies showed feasibility of long-term HPC storage, concerns remain about possible negative effects on their potency. To study the effects of long-term cryopreservation, we compared time to neutrophil and platelet recovery in 50 patients receiving two AHCT for multiple myeloma at least 2 years apart between 2006 and 2016, using HPC obtained from one mobilization and collection attempt before the first transplant. This product was divided into equivalent fractions allowing a minimum of 2 × 106 CD34+ cells/kg recipient’s weight. One fraction was used for the first transplant after median storage of 60 days (range, 17–165) and another fraction was used after median storage of 1448 days (range, 849–3510) at the second AHCT. Neutrophil recovery occurred at 14 days (median; range, 11–21) after the first and 13 days (10–20) after the second AHCT. Platelets recovered at a median of 16 days after both procedures. Considering other factors, such as disease status, conditioning and HPC dose, this single institution data demonstrated no reduction in the potency of HPC after long-term storage.

Journal article

Giebel S, Labopin M, Socie G, Pavlu J, Volin L, Remenyi P, Yakoub-Agha I, Orchard K, Michallet M, Stuhler G, Chaganti S, Murray M, Aljurf M, Bloor A, Passweg J, Finke J, Mohty M, Nagler Aet al., 2017, CYCLOPHOSPHAMIDE VERSUS ETOPOSIDE IN COMBINATION WITH TOTAL BODY IRRADIATION AS CONDITIONING FOR ADULTS WITH PH(-) ALL UNDERGOING ALLO-HCT. A STUDY FROM THE ACUTE LEUKEMIA WORKING PARTY OF THE EBMT, 22nd Congress of the European-Hematology-Association, Publisher: FERRATA STORTI FOUNDATION, Pages: 326-326, ISSN: 0390-6078

Conference paper

Khoder A, Sever M, Palanicawandar R, Pello O, Loaiza S, Bray E, Bradshaw A, Uddin S, Atta M, Selvaratnam V, Sevillano B, Monsalvo S, Altaf S, Innes A, Lozano S, Pavlu J, Auner H, Apperley J, Olavarria E, Kanfer Eet al., 2017, PLERIXAFOR EFFECTIVELY RESCUES BIOSIMILAR G-CSFALONE-BASED STEM CELL MOBILISATION FAILURES, Publisher: ELSEVIER SCI LTD, Pages: S55-S55, ISSN: 1465-3249

Conference paper

Pello OM, Innes AJ, Bradshaw A, Finn S-A, Uddin S, Bray E, Olavarria E, Apperley JF, Pavlu Jet al., 2017, BKV-specific T cells in the treatment of severe refractory haemorrhagic cystitis after HLA-haploidentical haematopoietic cell transplantation, EUROPEAN JOURNAL OF HAEMATOLOGY, Vol: 98, Pages: 632-634, ISSN: 0902-4441

Background:Haemorrhagic cystitis caused by BK virus (BKV) is a known complication of allogeneic haematopoietic cell transplantation (HCT) and is relatively common following HLA-haploidentical transplantation. Adoptive immunotransfer of virus-specific T cells from the donor is a promising therapeutic approach, although production of these cells is challenging, particularly when dealing with low-frequency T cells such as BKV-specific T cells.Case report:Here, we present a patient who, following haploidentical HCT, developed severe BKV haemorrhagic cystitis, resistant to standard therapy. He responded well to adoptive transfer of donor cells enriched in BKV-specific T cells using the new second-generation CliniMACS Prodigy and the Cytokine Capture System from Miltenyi Biotec. Treatment led to full resolution of both the symptoms and viraemia without unwanted complications.Conclusion:Our observations suggest that use of products enriched with BKV-specific T cells generated using this system is safe and efficient in HLA-haploidentical HCT where BKV cystitis can be a serious complication.

Journal article

Pavlu J, Labopin M, Zoellner AK, Sakellari I, Stelljes M, Finke J, Fanin R, Stuhler G, Afanasyev BV, Bloor AJ, Anagnostopoulos A, Mohty M, Giebel S, Nagler Aet al., 2017, Allogeneic hematopoietic cell transplantation for primary refractory acute lymphoblastic leukemia: A report from the Acute Leukemia Working Party of the EBMT, Cancer, Vol: 123, Pages: 1965-1970, ISSN: 0008-543X

BACKGROUND: Patients with primary refractory acute lymphoblastic leukemia (PREF ALL) who fail to achieve a complete remission(CR) after 2 courses of chemotherapy have a dismal prognosis without undergoing allogeneic hematopoietic cell transplantation(HCT). To the authors’ knowledge, there currently are no data regarding factors influencing transplantation outcomes. METHODS: Theauthors retrospectively studied outcomes of transplantation for cases of PREF ALL reported to European Society for Blood andMarrow Transplantation registry. Eligibility criteria for the current analysis included adult patients who underwent their first HCT forPREF ALL between 2000 and 2012. PREF disease was defined as the failure to achieve a morphological CR after 2 courses of inductionchemotherapy. RESULTS: Data regarding 86 adult patients were analyzed. With a median follow-up of 106 months, the probabilityof survival was 36% at 2 years and 23% at 5 years. The probability of leukemia-free survival was 28% and 17%, respectively, and theprobability of nonrecurrence mortality was 20% and 29%, respectively, at 2 years and 5 years. For 66 patients who achieved a CR(77%), the survival at 2 years and 5 years was 36% and 29%, respectively. In multivariate analysis, use of total body irradiation wasfound to be associated with improved survival. Total body irradiation and infusion of female hematopoietic cells into male recipientswas associated with improved leukemia-free survival. These findings were incorporated into a scoring system that identified 3 groups(those with 2, 1, or no prognostic factors) with survival rates of 57%, 22%, and 8%, respectively. CONCLUSIONS: Although overall thesepatients would clearly benefit from the introduction of novel antileukemic therapies, the data from the current study support the useof allogeneic HCT in selected patients with PREF ALL.

Journal article

Freeman S, Hodgkinson A, Nagra S, Khan N, Ferguson P, Houlton A, Crawley C, Gilleece M, Hunter A, Novitzky-Basso I, Pavlu J, Peniket A, Potter V, Protheroe R, Salim R, Russell N, Tholouli E, Siddique S, Craddock Cet al., 2017, Tracking MRD together with LSC Enriched Populations to Predict Transplant Outcomes in AML, ANNALS OF HEMATOLOGY, Vol: 96, Pages: S23-S24, ISSN: 0939-5555

Journal article

Pavlu J, Labopin M, Tischer J, Sakellari I, Stelljes M, Finke J, Fanin R, Stuhler G, Afanasyev BV, Bloor A, Anagnostopoulos A, Mohty M, Giebel S, Nagler Aet al., 2016, Allogeneic Hematopoietic Stem Cell Transplantation for Primary Refractory Acute Lymphoblastic Leukemia - a Report from the Acute Leukemia Working Party of the EBMT, 58th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

Conference paper

Patel A, Szydlo RM, Auner HW, Kanfer EJ, MacDonald DH, Milojkovic D, Altaf S, Innes A, Gabriel I, Rahemtulla A, Chaidos A, Karadimitris A, Olavarria E, Apperley JF, Pavlů Jet al., 2016, C-reactive protein prior to myeloablative allogeneic haematopoietic cell transplantation identifies patients at risk of early- and long-term mortality, British Journal of Haematology, Vol: 180, Pages: 889-892, ISSN: 1365-2141

Journal article

Monsalvo S, Sevillano B, Innes AJ, Lasa M, Skinner L, Stumpfle R, Altaf S, Yebra E, Macdonald D, Milojkovic D, Chaidos A, Gabriel I, Brett S, Broomhead R, Patel P, Waheed U, Pavlu J, Palanicawandar R, Kanfer E, Szydlo R, Apperley J, Olavarria Eet al., The Intensive Care Trial for Critically Ill Onco-Haematologic Patients: The Need for Response Criteria at 5 Days of Full Treatment to Separate Good Risk Patients and Avoid Futile Intensive Care Interventions, 59th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, Publisher: American Society of Hematology, Pages: 5987-5987, ISSN: 0006-4971

Conference paper

Avenoso D, Bradshaw A, Innes AJ, de la Fuente J, Olavarria E, Apperley J, Pavlu Jet al., Microbial Contamination of Haematopoietic Stem Cell Products: A Single Centre Experience, 59th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, Publisher: American Society of Hematology, Pages: 5741-5741, ISSN: 0006-4971

Conference paper

Pello O, Bradshaw A, Innes AJ, Finn SA, Bray E, Uddin S, Olavarria E, Apperley J, Pavlu Jet al., Clinical Efficacy of BK Virus Specific T-Cells in Treatment of Severe Refractory Hemorrhagic Cystitis after HLA Haploidentical Transplantation, 59th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, Publisher: American Society of Hematology, Pages: 5726-5726, ISSN: 0006-4971

Conference paper

Rohman PJ, Szydlo RM, Hobbs E, Palanicawandar R, Sevillano B, Monsalvo S, Innes AJ, Kanfer E, Milojkovic D, Gabriel I, Jakob C, MACDONALD D, CHAIDOS A, KARADIMITRIS A, APPERLEY J, OLAVARRIA E, PAVLU Jet al., Preconditioning Neutropenia Is a Key Prognostic Factor in Allogeneic Hematopoietic Cell Transplantation for High Risk Acute Myeloid Leukemia, 59th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, Publisher: American Society of Hematology, Pages: 3411-3411, ISSN: 0006-4971

Conference paper

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