Publications
164 results found
de Lavallade H, Garland P, Sekine T, et al., 2011, Repeated vaccination is required to optimize seroprotection against H1N1 in the immunocompromised host, HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, Vol: 96, Pages: 307-314, ISSN: 0390-6078
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- Citations: 91
Pavlu J, Szydlo RM, Goldman JM, et al., 2011, Three decades of transplantation for chronic myeloid leukemia: what have we learned?, BLOOD, Vol: 117, Pages: 755-763, ISSN: 0006-4971
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- Citations: 79
Marin D, Ibrahim AR, Lucas C, et al., 2011, Assessment of BCR-ABL1 Transcript Levels at 3 Months Is the Only Requirement for Predicting Outcome for Patients With Chronic Myeloid Leukemia Treated With Tyrosine Kinase Inhibitors, Journal of Clinical Oncology
Purpose We studied BCR-ABL1 transcript levels in patients with chronic myeloid leukemia in chronic phase (CML-CP) at 3, 6, and 12 months after starting imatinib to identify molecular milestones that would predict for overall survival (OS) and other outcomes more reliably than serial marrow cytogenetics.Patients and Methods We analyzed 282 patients with CML-CP who received imatinib 400 mg/d as first-line therapy followed by dasatinib or nilotinib if treatment with imatinib failed. We used a receiver operating characteristic curve to identify the cutoffs in transcript levels at 3, 6, and 12 months that would best predict patient outcome. We validated our findings in an independent cohort of 95 patients treated elsewhere.Results Patients with transcript levels of more than 9.84% (n = 68) at 3 months had significantly lower 8-year probabilities of OS (56.9% v 93.3%; P < .001), progression-free survival, cumulative incidence of complete cytogenetic response, and complete molecular response than those with higher transcript levels. Similarly, transcript levels of more than 1.67% (n = 87) at 6 months and more than 0.53% (n = 93) at 12 months identified high-risk patients. However, transcript levels at 3 months were the most strongly predictive for the various outcomes. When we compared OS for the groups defined molecularly at 6 and 12 months with the usual cytogenetic milestones, categorization by transcript numbers was the only independent predictor for OS (relative risk, 0.207; P < .001 and relative risk, 0.158; P < .001, respectively).Conclusion A single measurement of BCR-ABL1 transcripts performed at 3 months is the best way to identify patients destined to fare poorly, thereby allowing early clinical intervention.
Pavlu J, Shah R, Auner HW, et al., 2010, Preconditioning Level of C-Reactive Protein and Disease Stage Are Key Prognostic Factors In Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation, 52nd Annual Meeting of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, Pages: 1433-1434, ISSN: 0006-4971
Holroyd A, Phillips E, Szydlo R, et al., 2010, Response to Tyrosine Kinase Inhibitor Therapy In Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation for Advanced Phase Chronic Myeloid Leukemia, 52nd Annual Meeting of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, Pages: 1445-1445, ISSN: 0006-4971
Chaidos A, Szydlo RM, Kanfer EJ, et al., 2010, High Frequency and Cell Dose of Invariant NKT Cells In the Graft Are Associated with Lack of Clinically Significant Acute Gvhd In T Cell-Replete Sibling Allografts., 52nd Annual Meeting of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, Pages: 1051-1052, ISSN: 0006-4971
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- Citations: 1
de Lavallade H, Garland PL, Sekine T, et al., 2010, 2009 Pandemic Influenza A H1N1 Vaccination In the Patients with Hematologic Malignancies: Requirement for Repeated Dosing to Optimize Seroprotection, 52nd Annual Meeting of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, Pages: 297-298, ISSN: 0006-4971
Holroyd A, Phillips E, Szydlo R, et al., 2010, Response to Tyrosine Kinase Inhibitor Therapy In Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation for Advanced Phase Chrome Myeloid Leukemia, Pages: 1445-1445, ISSN: 0006-4971
De Lavallade H, Garland PL, Sekine T, et al., 2010, 2009 Pandemic Influenza A H1N1 Vaccination In the Patients with Hematologic Malignancies Requirement for Repeated Dosing to Optimize Seroprotec, Pages: 297-298, ISSN: 0006-4971
Pavlu J, Shah R, Auner HW, et al., 2010, Preconditioning Level of C Reactive Protein and Disease Stage Are Key Prognostic Factors In Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation, Pages: 1433-1434, ISSN: 0006-4971
Naresh KN, Pavlu J, 2010, Plasmacytoid dendritic cell nodules in bone marrow biopsies of chronic myelomonocytic leukemia, AMERICAN JOURNAL OF HEMATOLOGY, Vol: 85, Pages: 893-893, ISSN: 0361-8609
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- Citations: 6
Pavlu J, Kew AK, Taylor-Roberts B, et al., 2010, Optimizing patient selection for myeloablative allogeneic hematopoietic cell transplantation in chronic myeloid leukemia in chronic phase, BLOOD, Vol: 115, Pages: 4018-4020, ISSN: 0006-4971
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- Citations: 46
Garland P, de Lavallade H, Sekine T, et al., 2010, Severe 2009 H1N1 influenza in patients with haematological malignancies, 50th Annual Scientific Meeting of the British-Society-for-Haematology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 47-47, ISSN: 0007-1048
Pavlu J, Kew A, Taylor-Roberts B, et al., 2010, Optimizing patient selection for myeloablative allogeneic haemopoietic cell transplantation in chronic myeloid leukaemia in chronic phase, 36th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantat/9th Meeting of the EBMT Data-Management-Group/26th Meeting of the EBMT Nurses Group/2nd EBMT Qual Management Meeting, Publisher: NATURE PUBLISHING GROUP, Pages: S239-S239, ISSN: 0268-3369
Porkka K, Pavlu J, Contento A, et al., 2010, Tyrosine kinase inhibitor therapy is associated with a low risk of cytomegalovirus reactivation after allogeneic haematopoietic stem cell transplantation, 36th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantat/9th Meeting of the EBMT Data-Management-Group/26th Meeting of the EBMT Nurses Group/2nd EBMT Qual Management Meeting, Publisher: NATURE PUBLISHING GROUP, Pages: S38-S38, ISSN: 0268-3369
Pavlu J, Auner H, Ellis S, et al., 2010, LACE-conditioned autologous stem cell transplantation for relapsed or refractory diffuse large B-cell lymphoma: treatment outcome and risk factor analysis from a single centre, BONE MARROW TRANSPLANTATION, Vol: 45, Pages: S255-S255, ISSN: 0268-3369
Auner H, Mazzarella L, Cook L, et al., 2010, High rate of stem cell mobilization failure after thalidomide and cyclophosphamide induction therapy for myeloma, BONE MARROW TRANSPLANTATION, Vol: 45, Pages: S21-S21, ISSN: 0268-3369
Khalique Z, Pavlu J, Lefroy D, et al., 2010, Erythrocytapheresis in the prevention of recurrent myocardial infarction in sickle cell disease, AMERICAN JOURNAL OF HEMATOLOGY, Vol: 85, Pages: 91-91, ISSN: 0361-8609
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- Citations: 5
Pavlu J, Marin D, 2009, Dasatinib and Chronic Myeloid Leukemia: Two-Year Follow-up in Eight Clinical Trials, CLINICAL LYMPHOMA & MYELOMA, Vol: 9, Pages: 417-424, ISSN: 1557-9190
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- Citations: 17
Chaidos A, Giles C, Auner HW, et al., 2009, Second Autologous Stem Cell Transplantation Is Effective Salvage Therapy for Relapsed Multiple Myeloma, 51st Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, Pages: 507-507, ISSN: 0006-4971
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- Citations: 1
Auner HW, Owiti H, Giles C, et al., 2009, Ethnic Disparity in Access to Stem Cell Transplantation for Multiple Myeloma., 51st Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, Pages: 708-709, ISSN: 0006-4971
Auner HW, Mazzarella L, Cook L, et al., 2009, The Combination of Cyclophosphamide and Thalidomide During Induction Therapy for Multiple Myeloma Results in a High Rate of Stem Cell Mobilization Failure, 51st Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, Pages: 844-844, ISSN: 0006-4971
Pavlu J, Kew A, Taylor-Roberts B, et al., 2009, Optimizing Patient Selection for Allogeneic Stem Cell Transplantation in Chronic Myeloid Leukemia, 51st Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, Pages: 1317-1317, ISSN: 0006-4971
Pavlu J, Auner H, Szydlo R, et al., 2009, Allogeneic myeloablative haematopoietic stem cell transplantation for chronic myeloid leukaemia in the imatinib era, 35th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation, Publisher: NATURE PUBLISHING GROUP, Pages: S49-S49, ISSN: 0268-3369
Auner H, Giles C, Pavlu J, et al., 2009, Ethnicity and autologous stem cell transplantation in myeloma, 35th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation, Publisher: NATURE PUBLISHING GROUP, Pages: S148-S148, ISSN: 0268-3369
Auner HW, Giles C, Pavlu J, et al., 2009, Ethnicity and Myeloma: Experience of a Large UK Stem Cell Transplantation Center, Publisher: CIG MEDIA GROUP, LP, Pages: S84-S84, ISSN: 1557-9190
Bayley J, Pavlů J, Thompson M, 2009, Striking bone marrow plasmacytosis in a patient with sickle cell anaemia., Br J Haematol, Vol: 144
Marin D, Milojkovic D, Olavarria E, et al., 2008, European LeukemiaNet criteria for failure or suboptimal response reliably identify patients with CML in early chronic phase treated with imatinib whose eventual outcome is poor, BLOOD, Vol: 112, Pages: 4437-4444, ISSN: 0006-4971
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- Citations: 257
Klammer M, Giles C, Reid AG, et al., 2008, Incorporating Marrow Plasma Cell Infiltration at Diagnosis and Cytogenetic Features into Prognostic Scoring at Point of Autologous Stem Cell Transplantation for Multiple Myeloma, 50th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, Pages: 1140-1140, ISSN: 0006-4971
Pavlu J, Klammer M, Gabriel I, et al., 2008, Allogeneic Myeloablative Hematopoietic Stem Cell Transplantation for Chronic Myelogenous Leukemia in the Imatinib Era., 50th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, Pages: 357-357, ISSN: 0006-4971
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