Imperial College London

DrJamesPease

Faculty of MedicineNational Heart & Lung Institute

Reader in Leukocyte Biology
 
 
 
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Contact

 

+44 (0)20 7594 3162j.pease Website

 
 
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Location

 

109Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

122 results found

Pease JE, 2012, CCR1 ANTAGONISM FOR THE TREATMENT OF INFLAMMATORY DISEASES: FOCUS ON CCX-354, DRUGS OF THE FUTURE, Vol: 37, Pages: 735-739, ISSN: 0377-8282

Journal article

Nedjai B, Li H, Stroke IL, Wise EL, Webb ML, Merritt JR, Henderson I, Klon AE, Cole AG, Horuk R, Vaidehi N, Pease JEet al., 2012, Small molecule chemokine mimetics suggest a molecular basis for the observation that CXCL10 and CXCL11 are allosteric ligands of CXCR3, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 166, Pages: 912-923, ISSN: 0007-1188

Journal article

Pease JE, Fox JM, Kausar F, Day AMW, Osborne M, Goldblatt Jet al., 2012, Identification of a monocyte receptor for the atypical chemokine CXCL4, Chemotactic Cytokines, Molecular and Cellular Mechanisms in Health and Disease

Conference paper

Hua R, Pease JE, Sooranna SR, Viney JM, Nelson SM, Myatt L, Bennett PR, Johnson MRet al., 2012, Stretch and Inflammatory Cytokines Drive Myometrial Chemokine Expression Via NF-kappa B Activation, ENDOCRINOLOGY, Vol: 153, Pages: 481-491, ISSN: 0013-7227

Journal article

Parmentier CN, Fuerst E, McDonald J, Bowen H, Lee TH, Pease JE, Woszczek G, Cousins DJet al., 2012, Human T(H)2 cells respond to cysteinyl leukotrienes through selective expression of cysteinyl leukotriene receptor 1, J Allergy Clin Immunol, ISSN: 1097-6825

BACKGROUND: Allergic asthma is characterized by reversible airway obstruction and bronchial hyperresponsiveness associated with T(H)2 cell-mediated inflammation. Cysteinyl leukotrienes (CysLTs) are potent lipid mediators involved in bronchoconstriction, mucus secretion, and cell trafficking in asthmatic patients. Recent data have implicated CysLTs in the establishment and amplification of T(H)2 responses in murine models, although the precise mechanisms are unresolved. OBJECTIVES: Preliminary microarray studies suggested that human T(H)2 cells might selectively express cysteinyl leukotriene receptor 1 (CYSLTR1) mRNA. We sought to establish whether human T(H)2 cells are indeed a CysLT target cell type. METHODS: We examined the expression of CYSLTR1 using real-time PCR in human T(H)1 and T(H)2 cells. We functionally assessed cysteinyl leukotriene receptor 1 protein (CysLT(1)) expression using calcium flux, cyclic AMP, and chemotaxis assays. RESULTS: We show that human T(H)2 cells selectively express CYSLTR1 mRNA at high levels compared with T(H)1 cells after in vitro differentiation from naive precursors. Human T(H)2 cells are selectively responsive to CysLTs in a calcium flux assay when compared with T(H)1 cells with a rank order of potency similar to that described for CysLT(1) (leukotriene [LT] D(4) > LTC(4) > LTE(4)). We also show that LTD(4)-induced signaling in T(H)2 cells is mediated through CysLT(1) coupled to G(alpha)q and G(alpha)i proteins, and both pathways can be completely inhibited by selective CysLT(1) antagonists. LTD(4) is also found to possess potent chemotactic activity for T(H)2 cells at low nanomolar concentrations. CONCLUSIONS: These findings suggest a novel mechanism of action for CysLTs in the pathogenesis of asthma and provide a potential explanation for the anti-inflammatory effects of CysLT(1) antagonists.

Journal article

Evans JH, Horowitz A, Mehrabi M, Wise EL, Pease JE, Riley EM, Davis DMet al., 2011, A distinct subset of human NK cells expressing HLA-DR expand in response to IL-2 and can aid immune responses to BCG, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 41, Pages: 1924-1933, ISSN: 0014-2980

Journal article

Petit SJ, Wise EL, Chambers JC, Sehmi J, Chayen NE, Kooner JS, Pease JEet al., 2011, The CXCL16 A181V Mutation Selectively Inhibits Monocyte Adhesion to CXCR6 but Is Not Associated With Human Coronary Heart Disease, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol: 31, Pages: 914-920, ISSN: 1079-5642

Journal article

Hua R, Viney J, Sooranna SR, Pease J, Bennett PR, Johnson MRet al., 2011, Upregulation of Biologically Active Chemokines by Cytokines and Mechanical Stretch Via MAPK and NF kappa B Pathways in Human Myometrium, REPRODUCTIVE SCIENCES, Vol: 18, Pages: 313A-313A, ISSN: 1933-7191

Journal article

Pease JE, 2011, Targeting chemokine receptors in allergic disease, BIOCHEMICAL JOURNAL, Vol: 434, Pages: 11-24, ISSN: 0264-6021

Journal article

Waters V, Pease J, Kaiser P, 2010, The chicken chemokine repertoire - spot the difference?, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 112-112, ISSN: 0019-2805

Conference paper

Pease JE, 2010, Natural and synthetic mutants illuminate chemokine biology, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 12-12, ISSN: 0019-2805

Conference paper

Pease JE, 2010, Targeting CCR3, Publisher: Wiley-VCH, ISBN: 9783527321186

Book

Pease JE, Horuk R, 2010, Small Molecule Antagonists of Chemokine Receptors - is Promiscuity a Virtue?, CURRENT TOPICS IN MEDICINAL CHEMISTRY, Vol: 10, Pages: 1351-1358, ISSN: 1568-0266

Journal article

Pease JE, 2010, Is there a role for CCR8 in the pathogenesis of asthma?, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 40, Pages: 1110-1112, ISSN: 0954-7894

Journal article

Wise EL, Bonner KT, Williams TJ, Pease JEet al., 2010, A single nucleotide polymorphism in the CCR3 gene ablates receptor export to the plasma membrane, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 126, Pages: 150-157, ISSN: 0091-6749

Journal article

Collington SJ, Hallgren J, Pease JE, Jones TG, Rollins BJ, Westwick J, Austen KF, Williams TJ, Gurish MF, Weller CLet al., 2010, The Role of the CCL2/CCR2 Axis in Mouse Mast Cell Migration In Vitro and In Vivo, JOURNAL OF IMMUNOLOGY, Vol: 184, Pages: 6114-6123, ISSN: 0022-1767

Journal article

Hall SE, Mao A, Nicolaidou V, Finelli M, Wise EL, Nedjai B, Kanjanapangka J, Harirchian P, Chen D, Selchau V, Ribeiro S, Schyler S, Pease JE, Horuk R, Vaidehi Net al., 2009, Elucidation of Binding Sites of Dual Antagonists in the Human Chemokine Receptors CCR2 and CCR5, MOLECULAR PHARMACOLOGY, Vol: 75, Pages: 1325-1336, ISSN: 0026-895X

Journal article

Pease JE, Horuk R, 2009, Chemokine receptor antagonists: part 2, EXPERT OPINION ON THERAPEUTIC PATENTS, Vol: 19, Pages: 199-221, ISSN: 1354-3776

Journal article

Vaidehi N, Pease JE, Horuk R, 2009, MODELING SMALL MOLECULE-COMPOUND BINDING To G-PROTEIN-COUPLED RECEPTORS, CHEMOKINES, PT A, Vol: 460, Pages: 263-+, ISSN: 0076-6879

Journal article

Pease JE, Horuk R, 2009, Chemokine receptor antagonists: Part 1, EXPERT OPINION ON THERAPEUTIC PATENTS, Vol: 19, Pages: 39-58, ISSN: 1354-3776

Journal article

Pease JE, Williams TJ, 2009, Chemokines, Asthma and COPD, Editors: Barnes, Drazen, Rennard, Thomson, Publisher: Academic Press, ISBN: 9780123740014

The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Managementcontinues to provide a unique and authoritative comparison of asthma and COPD.

Book chapter

Petit SJ, Chayen NE, Pease JE, 2008, Site-directed mutagenesis of the chemokine receptor CXCR6 suggests a novel paradigm for interactions with the ligand CXCL16, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 38, Pages: 2337-2350, ISSN: 0014-2980

Journal article

Poh TY, Pease J, Young JR, Bumstead N, Kaiser Pet al., 2008, Re-evaluation of chicken CXCR1 determines the true gene structure - CXCLi1 (K60) and CXCLi2 (CAF/interleukin-8) are ligands for this receptor, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 283, Pages: 16408-16415

Journal article

Meiser A, Mueller A, Wise EL, McDonagh EM, Petit SJ, Saran N, Clark PC, Williams TJ, Pease JEet al., 2008, The chemokine receptor CXCR3 is degraded following internalization and is replenished at the cell surface by de novo synthesis of receptor, JOURNAL OF IMMUNOLOGY, Vol: 180, Pages: 6713-6724, ISSN: 0022-1767

Journal article

Verzijl D, Storelli S, Scholten DJ, Bosch L, Reinhart TA, Streblow DN, Tensen CP, Fitzsimons CP, Zaman GJR, Pease JE, de Esch IJP, Smit MJ, Leurs Ret al., 2008, Noncompetitive antagonism and inverse agonism as mechanism of action of nonpeptidergic antagonists at primate and rodent CXCR3 chemokine receptors, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol: 325, Pages: 544-555, ISSN: 0022-3565

Journal article

Qin S, Sui Y, Soloff AC, Junecko BAF, Kirschner DE, Murphey-Corb MA, Watkins SC, Tarwater PM, Pease JE, Barratt-Boyes SM, Reinhart TAet al., 2008, Chemokine and cytokine mediated loss of regulatory T cells in lymph nodes during pathogenic simian immunodeficiency virus infection, JOURNAL OF IMMUNOLOGY, Vol: 180, Pages: 5530-5536, ISSN: 0022-1767

Journal article

Mueller A, Meiser A, McDonagh EM, Fox JM, Petit SJ, Xanthou G, Williams TJ, Pease JEet al., 2008, CXCL4-induced migration of activated T lymphocytes is mediated by the chemokine receptor CXCR3, JOURNAL OF LEUKOCYTE BIOLOGY, Vol: 83, Pages: 875-882, ISSN: 0741-5400

Journal article

Bahar MW, Kenyon JC, Putz MM, Abrescia NGA, Pease JE, Wise EL, Stuart DI, Smith GL, Grimes JMet al., 2008, Structure and function of A41, a vaccinia virus chemokine binding protein, PLOS PATHOGENS, Vol: 4, ISSN: 1553-7366

Journal article

Wise EL, Duchesnes C, da Fonseca PCA, Allen RA, Williams TJ, Pease JEet al., 2007, Small molecule receptor agonists and antagonists of CCR3 provide insight into mechanisms of chemokine receptor activation, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 282, Pages: 27935-27943

Journal article

Sui Y, Tung Y-J, Qin S, Trichel A, Pease JE, Murphey-Corb MA, Reinhart TAet al., 2007, Comprehensive analysis of chemokine expression patterns in simian immunodeficiency virus-infected macaques reveals a skew in the balance of type 1 and type 2 chemokines in lymphoid tissues, JOURNAL OF MEDICAL PRIMATOLOGY, Vol: 36, Pages: 312-312, ISSN: 0047-2565

Journal article

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