Imperial College London

DrJamesPease

Faculty of MedicineNational Heart & Lung Institute

Reader in Leukocyte Biology
 
 
 
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Contact

 

+44 (0)20 7594 3162j.pease Website

 
 
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Location

 

109Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

122 results found

Wise E, Pease JE, 2007, Unravelling the mechanisms underpinning chemokine receptor activation and blockade by small molecules: a fine line between agonism and antagonism?, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 35, Pages: 755-759, ISSN: 0300-5127

Journal article

Egesten A, Eliasson M, Johansson HM, Olin AI, Morgelin M, Mueller A, Pease JE, Frick I-M, Bjorck Let al., 2007, The CXC chemokine MIG/CXCL9 is important in innate immunity against Streptococcus pyogenes, JOURNAL OF INFECTIOUS DISEASES, Vol: 195, Pages: 684-693, ISSN: 0022-1899

Journal article

Sandig H, Pease JE, Sabroe I, 2007, Contrary prostaglandins: the opposing roles of PGD(2) and its metabolites in leukocyte function, JOURNAL OF LEUKOCYTE BIOLOGY, Vol: 81, Pages: 372-382, ISSN: 0741-5400

Journal article

Wise EL, Pease JE, 2007, Antagonism of the chemokine receptor CCR3 as a potential therapeutic treatment for asthma., Therapeutic Strategies in Asthma: Current Treatments, Editors: Holgate, Polosa, Publisher: Clinical Pub Serv, ISBN: 9781846920158

Book chapter

Pease JE, 2007, Microbial suberversion and exploitation of the human chemokine network., Cytokines in human health, Editors: House, Descotes, Publisher: Humana Pr Inc, ISBN: 9781588294678

Chapters in this section review the ability of external influences to modify the expression, production, and activity of these molecules.

Book chapter

Najarro P, Fox JM, Smith GL, Struyf S, Proost P, Pease JEet al., 2006, Structure/function relationships of CCR8 agonists and antagonists. Amino-terminal extension of CCL1 by a single amino acid generates a partial agonist., J Biol Chem., Vol: 281, Pages: 36652-36661

Journal article

Pease JE, 2006, Tails of the unexpected - an atypical receptor for the chemokine RANTES/CCL5 expressed in brain, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 149, Pages: 460-462, ISSN: 0007-1188

Journal article

Vaidehi N, Schlyer S, Trabanino RJ, Floriano WB, Abrol R, Sharma S, Kochanny M, Koovakat S, Dunning L, Liang M, Fox JM, Lopes de Mendonca F, Pease JE, Goddard WA, Horuk Ret al., 2006, Predictions of CCR1 chemokine receptor structure and BX 471 antagonist binding followed by experimental validation, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 281, Pages: 27613-27620

Journal article

Pease JE, Williams TJ, 2006, Chemokines and their receptors in allergic disease, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 118, Pages: 305-318, ISSN: 0091-6749

Journal article

Najarro P, Gubser C, Hollinshead M, Fox J, Pease J, Smith GLet al., 2006, Yaba-like disease virus chemokine receptor 7L, a CCR8 orthologue, JOURNAL OF GENERAL VIROLOGY, Vol: 87, Pages: 809-816, ISSN: 0022-1317

Journal article

Schlyer SK, Horuk R, Koovakkat S, Kochanny MJ, Trabanino R, Goddard WA, Abrol R, Floriano WB, Pease J, Fox J, Lopez de Mendoca F, Sharma S, Nagarajan Vet al., 2006, The molecular basis of antagonist binding to CCR1: Molecular modeling and experiment, 231st National Meeting of the American-Chemical-Society, Publisher: AMER CHEMICAL SOC, ISSN: 0065-7727

Conference paper

Duchesnes UE, Murphy PM, Williams TJ, Pease JEet al., 2006, Alanine scanning mutagenesis of the chemokine receptor CCR3 reveals distinct extracellular residues involved in recognition of the eotaxin family of chemokines, MOLECULAR IMMUNOLOGY, Vol: 43, Pages: 1221-1231, ISSN: 0161-5890

Journal article

Sandig H, Andrew D, Barnes AA, Sabroe I, Pease Jet al., 2006, 9 alpha,11 beta-PGF(2) and its stereoisomer PGF(2 alpha) are novel agonists of the chemoattractant receptor, CRTH2, FEBS LETTERS, Vol: 580, Pages: 373-379, ISSN: 1873-3468

Journal article

Pease JE, 2006, Asthma, allergy and chemokines, CURRENT DRUG TARGETS, Vol: 7, Pages: 3-12, ISSN: 1389-4501

Journal article

Pease JE, Williams TJ, 2006, The attraction of chemokines as a target for specific anti-inflammatory therapy, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 147, Pages: S212-S221, ISSN: 0007-1188

Journal article

Sabroe I, Williams TJ, Pease JE, 2006, Eotaxins, Encyclopedia of Respiratory Medicine., Editors: Laurent, Shapiro, Publisher: Elsevier, ISBN: 9780124383609

Book chapter

Pease JE, Horuk R, 2005, CCR1 antagonists in clinical development, EXPERT OPINION ON INVESTIGATIONAL DRUGS, Vol: 14, Pages: 785-796, ISSN: 1354-3784

Journal article

Sabroe I, Jorritsma A, Stubbs VEL, Xanthou G, Jopling LA, Panath PD, Williams TJ, Murphy PM, Pease JEet al., 2005, The carboxyl terminus of the chemokine receptor CCR3 contains distinct domains which regulate chemotactic signaling and receptor down-regulation in a ligand-dependent manner, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 35, Pages: 1301-1310, ISSN: 0014-2980

Journal article

de Mendonca FL, da Fonseca PCA, Phillips RM, Saldanha JW, Williams TJ, Pease JEet al., 2005, Site-directed mutagenesis of CC chemokine receptor 1 reveals the mechanism of action of UCB 35625, a small molecule chemokine receptor antagonist, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 280, Pages: 4808-4816

Journal article

Fox JM, Pease JE, 2005, The molecular and cellular biology of CC chemokines and their receptors, CHEMOKINES, CHEMOKINE RECEPTORS, AND DISEASE, Vol: 55, Pages: 73-+, ISSN: 1063-5823

Journal article

Auger GA, Smith BM, Pease JE, Barker MDet al., 2004, The use of membrane translocating peptides to identify sites of interaction between the C5a receptor and downstream effector proteins, IMMUNOLOGY, Vol: 112, Pages: 590-596, ISSN: 0019-2805

Journal article

Bohm E, Sturm GJ, Weiglhofer I, Sandig H, Shichijo M, McNamee A, Pease JE, Kollroser M, Peskar BA, Heinemann Aet al., 2004, 11-dehydro-thromboxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 279, Pages: 7663-7670, ISSN: 0021-9258

Journal article

Najarro P, Lee HJ, Fox J, Pease J, Smith GLet al., 2003, Yaba-like disease virus protein 7L is a cell-surface receptor for chemokine CCL1, JOURNAL OF GENERAL VIROLOGY, Vol: 84, Pages: 3325-3336, ISSN: 0022-1317

Journal article

Xanthou G, Williams TJ, Pease JE, 2003, Molecular characterization of the chemokine receptor CXCR3: evidence for the involvement of distinct extracellular domains in a multi-step model of ligand binding and receptor activation, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 33, Pages: 2927-2936, ISSN: 0014-2980

Journal article

Conroy DM, Jopling LA, Lloyd CM, Hodge MR, Andrew DP, Williams TJ, Pease JE, Sabroe Iet al., 2003, CCR4 blockade does not inhibit allergic airways inflammation, JOURNAL OF LEUKOCYTE BIOLOGY, Vol: 74, Pages: 558-563, ISSN: 0741-5400

Journal article

Xanthou G, Duchesnes CE, Williams TJ, Pease JEet al., 2003, CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 33, Pages: 2241-2250, ISSN: 0014-2980

Journal article

Phillips RM, Stubbs VEL, Henson MR, Williams TJ, Pease JE, Sabroe Iet al., 2003, Variations in eosinophil chemokine responses: An investigation of CCR1 and CCR3 function, expression in atopy, and identification of a functional CCR1 promoter, JOURNAL OF IMMUNOLOGY, Vol: 170, Pages: 6190-6201, ISSN: 0022-1767

Journal article

Culley FJ, Fadlon EJ, Kirchem A, Williams TJ, Jose PJ, Pease JEet al., 2003, Proteoglycans are potent modulators of the biological responses of eosinophils to chemokines, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 33, Pages: 1302-1310, ISSN: 0014-2980

Journal article

Bohm E, Strum GJ, Weiglhofer I, Sandig H, Shichijo M, McNammee A, Pease JE, Peskar BA, Heinemann Aet al., 2003, 11-Dehydro-TXB2, a stable thromboxane metabolite, is a full CRTH2 agonist in human eosinophils and basophils, 9th Symposium of the Austrian-Pharmacological-Society, Publisher: KARGER, Pages: 213-213, ISSN: 0031-7012

Conference paper

Pease JE, Weller CL, Williams TJ, 2003, Regulation of eosinophil trafficking in asthma and allergy, CHEMOKINE ROLES IN IMMUNOREGULATION AND DISEASE, Vol: 45, Pages: 85-100, ISSN: 0947-6075

Journal article

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