Imperial College London

DrJamesPease

Faculty of MedicineNational Heart & Lung Institute

Reader in Leukocyte Biology
 
 
 
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Contact

 

+44 (0)20 7594 3162j.pease Website

 
 
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Location

 

109Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

122 results found

Pease J E, Weller CL, Williams TJ, 2003, Regulation of Eosinophil Trafficking in Asthma and Allergy, Chemokine Roles in Immunoregulation and Disease., Editors: Murphy, Horuk, Publisher: Springer, ISBN: 9783540402213

Book chapter

Nouri-Aria KT, Wilson D, Francis JN, Jopling LA, Jacobson MR, Hodge MR, Andrew DP, Till SJ, Varga EM, Williams TJ, Pease JE, Lloyd CM, Sabroe I, Durham SRet al., 2002, CCR4 in human allergen-induced late responses in the skin and lung, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 32, Pages: 1933-1938, ISSN: 0014-2980

Journal article

Auger GA, Pease JE, Shen XY, Xanthou G, Barker MDet al., 2002, Alanine scanning mutagenesis of CCR3 reveals that the three intracellular loops are essential for functional receptor expression, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 32, Pages: 1052-1058, ISSN: 0014-2980

Journal article

Jopling LA, Sabroe I, Andrew DP, Mitchell TJ, Li Y, Hodge MR, Williams TJ, Pease JEet al., 2002, The identification, characterization, and distribution of guinea pig CCR4 and epitope mapping of a blocking antibody, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 277, Pages: 6864-6873, ISSN: 0021-9258

Journal article

Sabroe I, Lloyd CM, Whyte MKB, Dower SK, Williams TJ, Pease JEet al., 2002, Chemokines, innate and adaptive immunity, and respiratory disease, EUROPEAN RESPIRATORY JOURNAL, Vol: 19, Pages: 350-355, ISSN: 0903-1936

Journal article

Durham S, Nouri-Aria KT, Wilson DR, Jacobson MR, Varga EM, Williams T, Pease J, Lloyd C, Sabroe Iet al., 2002, Regulation of CCR4 expression after segmental bronchial allergen challenge in atopic asthmatics, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 109, Pages: S41-S41, ISSN: 0091-6749

Journal article

Pease J E, Williams TJ, 2002, Chemokines, Asthma and COPD, Editors: Barnes, Publisher: Academic Press, ISBN: 9780120790289

Book chapter

Pease JE, Sabroe I, 2002, The role of interleukin-8 and its receptors in inflammatory lung disease: implications for therapy., Am J Respir Med, Vol: 1, Pages: 19-25, ISSN: 1175-6365

Neutrophils have been implicated in the pathogenesis of many inflammatory lung diseases, including the acute respiratory distress syndrome, chronic obstructive pulmonary disease and asthma. The CXC chemokine interleukin (IL)-8, is a potent neutrophil recruiting and activating factor and the detection of IL-8 in clinical samples from patients with these diseases has led clinicians to believe that antagonism of IL-8 may be a practicable therapeutic strategy for disease management. Work over the last decade has concentrated on both the molecular mechanisms by which IL-8 is produced in the inflammatory setting and also on the manner in which IL-8 activates the neutrophil. Expression of the IL-8 gene appears to be controlled by several components of the inflammatory milieu. Whilst lipopolysaccharide, IL-1beta and tumor necrosis factor-alpha are capable of augmenting IL-8 production, IL-10 is a potent inhibitor of IL-8 synthesis and appears to play an auto-regulatory role. Regulation of the IL-8 gene is under the control of nuclear factor kappaB which appears to be a primary target for corticosteroid-mediated repression of IL-8 production. IL-8 exerts is effects on neutrophils by binding with high affinity to two receptors on its cell surface, the chemokine receptors CXCR1 and CXCR2. These closely related receptors belong to the superfamily of G-protein coupled receptors, proteins that historically have proved amenable to antagonism by small molecules. The recent descriptions in the literature of highly potent small molecule antagonists of CXCR2 and their success in blocking in vivo trafficking of neutrophils suggest that antagonism of IL-8 at the receptor level is a viable therapeutic strategy. Clinical trials of such compounds will ultimately provide crucial information currently lacking and will define whether or not IL-8 blockade provides future therapy in pulmonary disease.

Journal article

Martinelli R, Sabroe I, LaRosa G, Williams TJ, Pease JEet al., 2001, The CC chemokine eotaxin (CCL11) is a partial agonist of CC chemokine receptor 2b, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 276, Pages: 42957-42964, ISSN: 0021-9258

Journal article

Nouri-Aria KT, Walker S, Jopling LA, Jacobson MR, Pease J, Sabroe I, Williams T, Durham SRet al., 2001, Up-regulation of CCR4 mRNA expression after intradermal allergen challenge in atopic rhinitics, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 31, Pages: 1149-1149, ISSN: 0954-7894

Journal article

Pease JE, Williams TJ, 2001, Eotaxin and asthma., Curr Opin Pharmacol, Vol: 1, Pages: 248-253, ISSN: 1471-4892

Eotaxin is a small protein that is produced in the lungs of asthmatic patients and is a potent chemoattractant for eosinophils. Eotaxin, a CC chemokine, stimulates the migration of eosinophils from the small blood vessels in the lungs by acting on the CC chemokine receptor CCR3, which is located on the leukocyte cell surface. In the past year, three low molecular weight compounds have been developed that can block this receptor. Such compounds may be developed into orally available drugs aimed at preventing eosinophil recruitment and, hence, the pathogenesis associated with the activation of these cells within the lung tissue.

Journal article

Sabroe I, Williams TJ, Pease JE, 2001, Roles of chemokines in the regulation of leucocyte recruitment, CLINICAL SCIENCE, Vol: 100, Pages: 359-362, ISSN: 0143-5221

Journal article

Mitchell TJ, Walley AJ, Pease JE, Venables PJW, Wiltshire S, Williams TJ, Cookson WOCMet al., 2000, Delta 32 deletion of CCR5 gene and association with asthma or atopy, LANCET, Vol: 356, Pages: 1491-1492, ISSN: 0140-6736

Journal article

Sabroe I, Pease JE, Williams TJ, 2000, Asthma and MIF: innately Th1 and Th2, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 30, Pages: 1194-1196, ISSN: 0954-7894

Journal article

Sabroe I, Peck MJ, Van Keulen BJ, Jorritsma A, Simmons G, Clapham PR, Williams TJ, Pease JEet al., 2000, A small molecule antagonist of chemokine receptors CCR1 and CCR3 - Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 275, Pages: 25985-25992, ISSN: 0021-9258

Journal article

Hartnell A, Pease J E, Conroy DM, Williams TJet al., 2000, Chemokines and Eosinophils, Asthma & Rhinitis, Editors: Holgate, Busse, ISBN: 9780632041756

Book chapter

Crass T, Bautsch W, Cain SA, Pease JE, Monk PNet al., 1999, Receptor activation by human C5a des Arg(74) but not intact C5a is dependent on an interaction between Glu(199) of the receptor and Lys(68) of the ligand, BIOCHEMISTRY, Vol: 38, Pages: 9712-9717, ISSN: 0006-2960

Journal article

Sabroe I, Hartnell A, Jopling LA, Bel S, Ponath PD, Pease JE, Collins PD, Williams TJet al., 1999, Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways, JOURNAL OF IMMUNOLOGY, Vol: 162, Pages: 2946-2955, ISSN: 0022-1767

Journal article

Pease JE, Wang J, Ponath PD, Murphy PMet al., 1998, The N-terminal extracellular segments of the chemokine receptors CCR1 and CCR3 are determinants for MIP-1 alpha and eotaxin binding, respectively, but a second domain is essential for efficient receptor activation, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 273, Pages: 19972-19976, ISSN: 0021-9258

Journal article

Pease JE, Murphy PM, 1998, Microbial corruption of the chemokine system: An expanding paradigm, SEMINARS IN IMMUNOLOGY, Vol: 10, Pages: 169-178, ISSN: 1044-5323

Journal article

Youn BS, Zhang SM, Lee EK, Park DH, Broxmeyer HE, Murphy PM, Locati M, Pease JE, Kim KK, Antol K, Kwon BSet al., 1997, Molecular cloning of leukotactin-1: A novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3, JOURNAL OF IMMUNOLOGY, Vol: 159, Pages: 5201-5205, ISSN: 0022-1767

Journal article

Alkhatib G, Berger EA, Murphy PM, Pease JEet al., 1997, Determinants of HIV-1 coreceptor function on CC chemokine receptor 3 - Importance of both extracellular and transmembrane/cytoplasmic regions, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 272, Pages: 20420-20426, ISSN: 0021-9258

Journal article

Tiffany HL, Lautens LL, Gao JL, Pease J, Locati M, Combadiere C, Modi W, Bonner TI, Murphy PMet al., 1997, Identification of CCR8: A human monocyte and thymus receptor for the CC chemokine I-309, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 186, Pages: 165-170, ISSN: 0022-1007

Journal article

Monk PN, Barker MD, Pease JE, Crass T, Bautsch Wet al., 1996, Studies on the interaction between human C5A and its receptor, IMMUNOLOGY, Vol: 89, Pages: OM116-OM116, ISSN: 0019-2805

Journal article

Murdoch C, Barker MD, Pease JE, Finn A, Monk PNet al., 1996, Leukocyte chemoattractant receptor expression on endothelial and epithelial cells, IMMUNOLOGY, Vol: 89, Pages: OM115-OM115, ISSN: 0019-2805

Journal article

MONK PN, BARKER MD, PARTRIDGE LJ, PEASE JEet al., 1995, MUTATION OF GLUTAMATE-199 OF THE HUMAN C5A RECEPTOR DEFINES A BINDING-SITE FOR LIGAND DISTINCT FROM THE RECEPTOR N-TERMINUS, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 270, Pages: 16625-16629, ISSN: 0021-9258

Journal article

MONK PN, PEASE JE, MARLAND G, BARKER MDet al., 1994, MUTATION OF ASPARTATE-82 OF THE HUMAN C5A RECEPTOR ABOLISHES THE SECRETORY RESPONSE TO HUMAN C5A IN TRANSFECTED RAT BASOPHILIC LEUKEMIA-CELLS, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 24, Pages: 2922-2925, ISSN: 0014-2980

Journal article

PEASE JE, BURTON DR, BARKER MD, 1994, SITE-DIRECTED MUTAGENESIS OF THE COMPLEMENT C5A RECEPTOR - EXAMINATION OF A MODEL FOR ITS INTERACTION WITH THE LIGAND C5A, MOLECULAR IMMUNOLOGY, Vol: 31, Pages: 733-737, ISSN: 0161-5890

Journal article

MONK PN, PEASE JE, BARKER MD, 1994, C5A STIMULUS-SECRETION COUPLING IN RAT BASOPHILIC LEUKEMIA (RBL-2H3) CELLS TRANSFECTED WITH THE HUMAN C5A RECEPTOR IS MEDIATED BY PERTUSSIS AND CHOLERA TOXIN-SENSITIVE G-PROTEINS, BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL, Vol: 32, Pages: 13-20, ISSN: 1039-9712

Journal article

PEASE JE, BURTON DR, BARKER MD, 1994, GENERATION OF CHIMERIC C5A/FORMYL PEPTIDE RECEPTORS - TOWARDS THE IDENTIFICATION OF THE HUMAN C5A RECEPTOR-BINDING SITE, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 24, Pages: 211-215, ISSN: 0014-2980

Journal article

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