Publications
137 results found
Pease JE, Williams TJ, 2009, Chemokines, Asthma and COPD, Editors: Barnes, Drazen, Rennard, Thomson, Publisher: Academic Press, ISBN: 9780123740014
The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Managementcontinues to provide a unique and authoritative comparison of asthma and COPD.
Pease JE, Williams TJ, 2008, Chemokines, Asthma and COPD: Basic Mechanisms and Clinical Management, Pages: 313-325, ISBN: 9780123740014
Chemokines have multiple roles in the organization of the immune system under basal conditions and during infection, and are also involved in angiogenesis. A crucial role of chemokines is the recruitment of different types of leukocytes from the blood to the sites of inflammation. Most of the known chemokines belong to two major families defined by the position of four conserved cysteine residues. The largest family is the CC chemokine family (28 in number), which possesses two adjacent cysteines in the vicinity of the N-terminus of the mature peptide. The CXC family (16 members) has two cysteine residues in this same region, but with an interposed amino acid. Chemokines are thought to bind to presenting molecules on the luminal surface of the venular endothelium, such as glycosaminoglycans, where the chemokines engage their receptors on the leukocyte surface. A combination of clinical observations, in vitro cell biology and in vivo animal modeling has delineated potentially important mechanisms underlying lung inflammation in COPD and asthma. These extensive studies support the hypothesis that chemokines have a fundamental role in regulating leukocyte trafficking in inflammatory disease. The chemokine receptors represent novel targets for treatment and therapeutic compounds have been described with efficacy in vitro and in vivo.
Petit SJ, Chayen NE, Pease JE, 2008, Site-directed mutagenesis of the chemokine receptor CXCR6 suggests a novel paradigm for interactions with the ligand CXCL16, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 38, Pages: 2337-2350, ISSN: 0014-2980
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- Citations: 21
Poh TY, Pease J, Young JR, et al., 2008, Re-evaluation of chicken CXCR1 determines the true gene structure - CXCLi1 (K60) and CXCLi2 (CAF/interleukin-8) are ligands for this receptor, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 283, Pages: 16408-16415
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- Citations: 47
Meiser A, Mueller A, Wise EL, et al., 2008, The chemokine receptor CXCR3 is degraded following internalization and is replenished at the cell surface by de novo synthesis of receptor, JOURNAL OF IMMUNOLOGY, Vol: 180, Pages: 6713-6724, ISSN: 0022-1767
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- Citations: 99
Verzijl D, Storelli S, Scholten DJ, et al., 2008, Noncompetitive antagonism and inverse agonism as mechanism of action of nonpeptidergic antagonists at primate and rodent CXCR3 chemokine receptors, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol: 325, Pages: 544-555, ISSN: 0022-3565
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- Citations: 52
Qin S, Sui Y, Soloff AC, et al., 2008, Chemokine and cytokine mediated loss of regulatory T cells in lymph nodes during pathogenic simian immunodeficiency virus infection, JOURNAL OF IMMUNOLOGY, Vol: 180, Pages: 5530-5536, ISSN: 0022-1767
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- Citations: 35
Mueller A, Meiser A, McDonagh EM, et al., 2008, CXCL4-induced migration of activated T lymphocytes is mediated by the chemokine receptor CXCR3, JOURNAL OF LEUKOCYTE BIOLOGY, Vol: 83, Pages: 875-882, ISSN: 0741-5400
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- Citations: 80
Bahar MW, Kenyon JC, Putz MM, et al., 2008, Structure and function of A41, a vaccinia virus chemokine binding protein, PLOS PATHOGENS, Vol: 4, ISSN: 1553-7366
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- Citations: 51
Wise EL, Duchesnes C, da Fonseca PCA, et al., 2007, Small molecule receptor agonists and antagonists of CCR3 provide insight into mechanisms of chemokine receptor activation, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 282, Pages: 27935-27943
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- Citations: 51
Sui Y, Tung Y-J, Qin S, et al., 2007, Comprehensive analysis of chemokine expression patterns in simian immunodeficiency virus-infected macaques reveals a skew in the balance of type 1 and type 2 chemokines in lymphoid tissues, JOURNAL OF MEDICAL PRIMATOLOGY, Vol: 36, Pages: 312-312, ISSN: 0047-2565
Wise E, Pease JE, 2007, Unravelling the mechanisms underpinning chemokine receptor activation and blockade by small molecules: a fine line between agonism and antagonism?, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 35, Pages: 755-759, ISSN: 0300-5127
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- Citations: 4
Egesten A, Eliasson M, Johansson HM, et al., 2007, The CXC chemokine MIG/CXCL9 is important in innate immunity against <i>Streptococcus pyogenes</i>, JOURNAL OF INFECTIOUS DISEASES, Vol: 195, Pages: 684-693, ISSN: 0022-1899
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- Citations: 79
Wise EL, Pease JE, 2007, Antagonism of the chemokine receptor CCR3 as a potential therapeutic treatment for asthma., Therapeutic Strategies in Asthma: Current Treatments, Editors: Holgate, Polosa, Publisher: Clinical Pub Serv, ISBN: 9781846920158
Sandig H, Pease JE, Sabroe I, 2007, Contrary prostaglandins:: the opposing roles of PGD<sub>2</sub> and its metabolites in leukocyte function, JOURNAL OF LEUKOCYTE BIOLOGY, Vol: 81, Pages: 372-382, ISSN: 0741-5400
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- Citations: 46
Pease J, 2007, CCR4 chemokine receptor, xPharm: The Comprehensive Pharmacology Reference, Pages: 1-8, ISBN: 9780080552323
CCR4 is the sole receptor identified to date for the chemokines CCL22/ .... © 2007 Elsevier Inc. All rights reserved.
Pease JE, 2007, Microbial suberversion and exploitation of the human chemokine network., Cytokines in human health, Editors: House, Descotes, Publisher: Humana Pr Inc, ISBN: 9781588294678
Chapters in this section review the ability of external influences to modify the expression, production, and activity of these molecules.
Najarro P, Fox JM, Smith GL, et al., 2006, Structure/function relationships of CCR8 agonists and antagonists. Amino-terminal extension of CCL1 by a single amino acid generates a partial agonist., J Biol Chem., Vol: 281, Pages: 36652-36661
Pease JE, 2006, Tails of the unexpected - an atypical receptor for the chemokine RANTES/CCL5 expressed in brain, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 149, Pages: 460-462, ISSN: 0007-1188
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- Citations: 11
Vaidehi N, Schlyer S, Trabanino RJ, et al., 2006, Predictions of CCR1 chemokine receptor structure and BX 471 antagonist binding followed by experimental validation, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 281, Pages: 27613-27620
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- Citations: 85
Pease JE, Williams TJ, 2006, Chemokines and their receptors in allergic disease, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 118, Pages: 305-318, ISSN: 0091-6749
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- Citations: 77
Najarro P, Gubser C, Hollinshead M, et al., 2006, Yaba-like disease virus chemokine receptor 7L, a CCR8 orthologue, JOURNAL OF GENERAL VIROLOGY, Vol: 87, Pages: 809-816, ISSN: 0022-1317
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- Citations: 7
Schlyer SK, Horuk R, Koovakkat S, et al., 2006, The molecular basis of antagonist binding to CCR1: Molecular modeling and experiment, 231st National Meeting of the American-Chemical-Society, Publisher: AMER CHEMICAL SOC, ISSN: 0065-7727
Duchesnes UE, Murphy PM, Williams TJ, et al., 2006, Alanine scanning mutagenesis of the chemokine receptor CCR3 reveals distinct extracellular residues involved in recognition of the eotaxin family of chemokines, MOLECULAR IMMUNOLOGY, Vol: 43, Pages: 1221-1231, ISSN: 0161-5890
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- Citations: 25
Sandig H, Andrew D, Barnes AA, et al., 2006, 9α,11β-PGF<sub>2</sub> and its stereoisomer PGF<sub>2α</sub> are novel agonists of the chemoattractant receptor, CRTH2, FEBS LETTERS, Vol: 580, Pages: 373-379, ISSN: 1873-3468
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- Citations: 42
Sabroe I, Williams TJ, Pease JE, 2006, EOTAXINS, Encyclopedia of Respiratory Medicine: Volume 1-4, ISBN: 9780123708793
The Eotaxins are small proteins secreted during allergic reactions that have the ability to attract eosinophils and certain other cell types from the blood. Three of these CC-chemokines have been described, Eotaxin-1, -2, and -3. They induce leukocyte recruitment by acting on a receptor, CCR3, which is highly expressed on the surface of eosinophils and also on basophils, mast cells, and a subpopulation of the Th2 lymphocytes. Neutralization of Eotaxin-1 by monoclonal antibodies has been shown to suppress eosinophil accumulation during allergic reactions in man and animal models. Small molecule antagonists are under development with the aim of blocking eosinophil recruitment and, as a consequence, inhibiting the lung dysfunction and tissue remodeling associated with eosinophil activation.
Pease JE, 2006, Asthma, allergy and chemokines, CURRENT DRUG TARGETS, Vol: 7, Pages: 3-12, ISSN: 1389-4501
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- Citations: 72
Pease JE, Williams TJ, 2006, The attraction of chemokines as a target for specific anti-inflammatory therapy, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 147, Pages: S212-S221, ISSN: 0007-1188
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- Citations: 62
Sabroe I, Williams TJ, Pease JE, 2006, Eotaxins, Encyclopedia of Respiratory Medicine., Editors: Laurent, Shapiro, Publisher: Elsevier, ISBN: 9780124383609
Pease JE, Horuk R, 2005, CCR1 antagonists in clinical development, EXPERT OPINION ON INVESTIGATIONAL DRUGS, Vol: 14, Pages: 785-796, ISSN: 1354-3784
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- Citations: 30
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