Publications
137 results found
Sabroe I, Jorritsma A, Stubbs VEL, et al., 2005, The carboxyl terminus of the chemokine receptor CCR3 contains distinct domains which regulate chemotactic signaling and receptor down-regulation in a ligand-dependent manner, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 35, Pages: 1301-1310, ISSN: 0014-2980
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- Citations: 18
de Mendonça FL, da Fonseca PCA, Phillips RM, et al., 2005, Site-directed mutagenesis of CC chemokine receptor 1 reveals the mechanism of action of UCB 35625, a small molecule chemokine receptor antagonist, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 280, Pages: 4808-4816
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- Citations: 65
Fox JM, Pease JE, 2005, The molecular and cellular biology of CC chemokines and their receptors, CHEMOKINES, CHEMOKINE RECEPTORS, AND DISEASE, Vol: 55, Pages: 73-+, ISSN: 1063-5823
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- Citations: 3
Auger GA, Smith BM, Pease JE, et al., 2004, The use of membrane translocating peptides to identify sites of interaction between the C5a receptor and downstream effector proteins, IMMUNOLOGY, Vol: 112, Pages: 590-596, ISSN: 0019-2805
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- Citations: 4
Böhm E, Sturm GJ, Weiglhofer I, et al., 2004, 11-dehydro-thromboxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 279, Pages: 7663-7670, ISSN: 0021-9258
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- Citations: 93
Najarro P, Lee HJ, Fox J, et al., 2003, Yaba-like disease virus protein 7L is a cell-surface receptor for chemokine CCL1, JOURNAL OF GENERAL VIROLOGY, Vol: 84, Pages: 3325-3336, ISSN: 0022-1317
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- Citations: 12
Xanthou G, Williams TJ, Pease JE, 2003, Molecular characterization of the chemokine receptor CXCR3: evidence for the involvement of distinct extracellular domains in a multi-step model of ligand binding and receptor activation, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 33, Pages: 2927-2936, ISSN: 0014-2980
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- Citations: 75
Conroy DM, Jopling LA, Lloyd CM, et al., 2003, CCR4 blockade does not inhibit allergic airways inflammation, JOURNAL OF LEUKOCYTE BIOLOGY, Vol: 74, Pages: 558-563, ISSN: 0741-5400
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- Citations: 48
Xanthou G, Duchesnes CE, Williams TJ, et al., 2003, CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 33, Pages: 2241-2250, ISSN: 0014-2980
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- Citations: 98
Phillips RM, Stubbs VEL, Henson MR, et al., 2003, Variations in eosinophil chemokine responses: An investigation of CCR1 and CCR3 function, expression in atopy, and identification of a functional CCR1 promoter, JOURNAL OF IMMUNOLOGY, Vol: 170, Pages: 6190-6201, ISSN: 0022-1767
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- Citations: 37
Culley FJ, Fadlon EJ, Kirchem A, et al., 2003, Proteoglycans are potent modulators of the biological responses of eosinophils to chemokines, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 33, Pages: 1302-1310, ISSN: 0014-2980
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- Citations: 36
Pease JE, Weller CL, Williams TJ, 2003, Regulation of eosinophil trafficking in asthma and allergy, CHEMOKINE ROLES IN IMMUNOREGULATION AND DISEASE, Vol: 45, Pages: 85-100, ISSN: 0947-6075
Böhm E, Strum GJ, Weiglhofer I, et al., 2003, 11-Dehydro-TXB<sub>2</sub>, a stable thromboxane metabolite, is a full CRTH2 agonist in human eosinophils and basophils, 9th Symposium of the Austrian-Pharmacological-Society, Publisher: KARGER, Pages: 213-213, ISSN: 0031-7012
Pease J E, Weller CL, Williams TJ, 2003, Regulation of Eosinophil Trafficking in Asthma and Allergy, Chemokine Roles in Immunoregulation and Disease., Editors: Murphy, Horuk, Publisher: Springer, ISBN: 9783540402213
Nouri-Aria KT, Wilson D, Francis JN, et al., 2002, CCR4 in human allergen-induced late responses in the skin and lung, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 32, Pages: 1933-1938, ISSN: 0014-2980
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- Citations: 54
Auger GA, Pease JE, Shen X, et al., 2002, Alanine scanning mutagenesis of CCR3 reveals that the three intracellular loops are essential for functional receptor expression, European Journal of Immunology, Vol: 32, Pages: 1052-1058, ISSN: 0014-2980
Auger GA, Pease JE, Shen XY, et al., 2002, Alanine scanning mutagenesis of CCR3 reveals that the three intracellular loops are essential for functional receptor expression, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 32, Pages: 1052-1058, ISSN: 0014-2980
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- Citations: 33
Jopling LA, Sabroe I, Andrew DP, et al., 2002, The identification, characterization, and distribution of guinea pig CCR4 and epitope mapping of a blocking antibody, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 277, Pages: 6864-6873, ISSN: 0021-9258
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- Citations: 17
Sabroe I, Lloyd CM, Whyte MKB, et al., 2002, Chemokines, innate and adaptive immunity, and respiratory disease, EUROPEAN RESPIRATORY JOURNAL, Vol: 19, Pages: 350-355, ISSN: 0903-1936
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- Citations: 48
Durham S, Nouri-Aria KT, Wilson DR, et al., 2002, Regulation of CCR4 expression after segmental bronchial allergen challenge in atopic asthmatics, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 109, Pages: S41-S41, ISSN: 0091-6749
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- Citations: 1
Pease J E, Williams TJ, 2002, Chemokines, Asthma and COPD, Editors: Barnes, Publisher: Academic Press, ISBN: 9780120790289
Pease JE, Sabroe I, 2002, The role of interleukin-8 and its receptors in inflammatory lung disease: implications for therapy., Am J Respir Med, Vol: 1, Pages: 19-25, ISSN: 1175-6365
Neutrophils have been implicated in the pathogenesis of many inflammatory lung diseases, including the acute respiratory distress syndrome, chronic obstructive pulmonary disease and asthma. The CXC chemokine interleukin (IL)-8, is a potent neutrophil recruiting and activating factor and the detection of IL-8 in clinical samples from patients with these diseases has led clinicians to believe that antagonism of IL-8 may be a practicable therapeutic strategy for disease management. Work over the last decade has concentrated on both the molecular mechanisms by which IL-8 is produced in the inflammatory setting and also on the manner in which IL-8 activates the neutrophil. Expression of the IL-8 gene appears to be controlled by several components of the inflammatory milieu. Whilst lipopolysaccharide, IL-1beta and tumor necrosis factor-alpha are capable of augmenting IL-8 production, IL-10 is a potent inhibitor of IL-8 synthesis and appears to play an auto-regulatory role. Regulation of the IL-8 gene is under the control of nuclear factor kappaB which appears to be a primary target for corticosteroid-mediated repression of IL-8 production. IL-8 exerts is effects on neutrophils by binding with high affinity to two receptors on its cell surface, the chemokine receptors CXCR1 and CXCR2. These closely related receptors belong to the superfamily of G-protein coupled receptors, proteins that historically have proved amenable to antagonism by small molecules. The recent descriptions in the literature of highly potent small molecule antagonists of CXCR2 and their success in blocking in vivo trafficking of neutrophils suggest that antagonism of IL-8 at the receptor level is a viable therapeutic strategy. Clinical trials of such compounds will ultimately provide crucial information currently lacking and will define whether or not IL-8 blockade provides future therapy in pulmonary disease.
Martinelli R, Sabroe I, LaRosa G, et al., 2001, The CC chemokine eotaxin (CCL11) is a partial agonist of CC chemokine receptor 2b, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 276, Pages: 42957-42964, ISSN: 0021-9258
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- Citations: 62
Nouri-Aria KT, Walker S, Jopling LA, et al., 2001, Up-regulation of CCR4 mRNA expression after intradermal allergen challenge in atopic rhinitics, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 31, Pages: 1149-1149, ISSN: 0954-7894
Pease JE, Williams TJ, 2001, Eotaxin and asthma., Curr Opin Pharmacol, Vol: 1, Pages: 248-253, ISSN: 1471-4892
Eotaxin is a small protein that is produced in the lungs of asthmatic patients and is a potent chemoattractant for eosinophils. Eotaxin, a CC chemokine, stimulates the migration of eosinophils from the small blood vessels in the lungs by acting on the CC chemokine receptor CCR3, which is located on the leukocyte cell surface. In the past year, three low molecular weight compounds have been developed that can block this receptor. Such compounds may be developed into orally available drugs aimed at preventing eosinophil recruitment and, hence, the pathogenesis associated with the activation of these cells within the lung tissue.
Sabroe I, Williams TJ, Pease JE, 2001, Roles of chemokines in the regulation of leucocyte recruitment, CLINICAL SCIENCE, Vol: 100, Pages: 359-362, ISSN: 0143-5221
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- Citations: 4
Mitchell TJ, Walley AJ, Pease JE, et al., 2000, Delta 32 deletion of CCR5 gene and association with asthma or atopy, LANCET, Vol: 356, Pages: 1491-1492, ISSN: 0140-6736
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- Citations: 39
Sabroe I, Pease JE, Williams TJ, 2000, Asthma and MIF: innately Th1 and Th2, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 30, Pages: 1194-1196, ISSN: 0954-7894
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- Citations: 8
Sabroe I, Peck MJ, Van Keulen BJ, et al., 2000, A small molecule antagonist of chemokine receptors CCR1 and CCR3 - Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 275, Pages: 25985-25992, ISSN: 0021-9258
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- Citations: 187
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