Imperial College London
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DrJamesPease

Faculty of Medicine, National Heart & Lung Institute

Reader in Leukocyte Biology
 
 
 
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Contact

 

+44 (0)20 7594 3162j.pease Website

 
 
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Location

 

109Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lloyd:2019:10.1126/sciimmunol.aav7638,
author = {Lloyd, C and Puttur, F and Denney, L and Gregory, L and Vuononvirta, J and Oliver, R and McGhee, E and Pease, J and Krummel, MF and Headley, MB and Carlin, L},
doi = {10.1126/sciimmunol.aav7638},
journal = {Science Immunology},
title = {Pulmonary environmental cues drive group 2 innate lymphoid cell dynamics in mice and humans},
url = {http://dx.doi.org/10.1126/sciimmunol.aav7638},
volume = {4},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Group 2 innate lymphoid cells (ILC2s) are enriched in mucosal tissues (e.g., lung) and respond to epithelial cell–derived cytokines initiating type 2 inflammation. During inflammation, ILC2 numbers are increased in the lung. However, the mechanisms controlling ILC2 trafficking and motility within inflamed lungs remain unclear and are crucial for understanding ILC2 function in pulmonary immunity. Using several approaches, including lung intravital microscopy, we demonstrate that pulmonary ILC2s are highly dynamic, exhibit amoeboid-like movement, and aggregate in the lung peribronchial and perivascular spaces. They express distinct chemokine receptors, including CCR8, and actively home to CCL8 deposits located around the airway epithelium. Within lung tissue, ILC2s were particularly motile in extracellular matrix–enriched regions. We show that collagen-I drives ILC2 to markedly change their morphology by remodeling their actin cytoskeleton to promote environmental exploration critical for regulating eosinophilic inflammation. Our study provides previously unappreciated insights into ILC2 migratory patterns during inflammation and highlights the importance of environmental guidance cues in the lung in controlling ILC2 dynamics.
AU  - Lloyd,C
AU  - Puttur,F
AU  - Denney,L
AU  - Gregory,L
AU  - Vuononvirta,J
AU  - Oliver,R
AU  - McGhee,E
AU  - Pease,J
AU  - Krummel,MF
AU  - Headley,MB
AU  - Carlin,L
DO  - 10.1126/sciimmunol.aav7638
PY  - 2019///
SN  - 2470-9468
TI  - Pulmonary environmental cues drive group 2 innate lymphoid cell dynamics in mice and humans
T2  - Science Immunology
UR  - http://dx.doi.org/10.1126/sciimmunol.aav7638
UR  - http://hdl.handle.net/10044/1/70584
VL  - 4
ER  -
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