Imperial College London
Portrait Picture

DrJamesPease

Faculty of Medicine, National Heart & Lung Institute

Reader in Leukocyte Biology
 
 
 
//

Contact

 

+44 (0)20 7594 3162j.pease Website

 
 
//

Location

 

109Sir Alexander Fleming BuildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Solari:2015:10.1016/j.ejphar.2015.05.018,
author = {Solari, R and Pease, JE},
doi = {10.1016/j.ejphar.2015.05.018},
journal = {European Journal of Pharmacology},
pages = {167--177},
title = {Targeting chemokine receptors in disease - a case study of CCR4.},
url = {http://dx.doi.org/10.1016/j.ejphar.2015.05.018},
volume = {763},
year = {2015}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Since their early 1990s, the chemokine receptor family of G protein-coupled receptors (GPCRs) has been the source of much pharmacological endeavour. Best known for their key roles in recruiting leukocytes to sites of infection and inflammation, the receptors present themselves as plausible drug targets for therapeutic intervention. In this article, we will focus our attention upon CC Chemokine Receptor Four (CCR4) which has been implicated in diseases as diverse as allergic asthma and lymphoma. We will review the discovery of the receptors and their ligands, their perceived roles in disease and the successful targeting of CCR4 by both small molecule antagonists and monoclonal antibodies. We will also discuss future directions and strategies for drug discovery in this field.
AU  - Solari,R
AU  - Pease,JE
DO  - 10.1016/j.ejphar.2015.05.018
EP  - 177
PY  - 2015///
SN  - 0014-2999
SP  - 167
TI  - Targeting chemokine receptors in disease - a case study of CCR4.
T2  - European Journal of Pharmacology
UR  - http://dx.doi.org/10.1016/j.ejphar.2015.05.018
UR  - http://hdl.handle.net/10044/1/26191
VL  - 763
ER  -
Download