Imperial College London

Professor José R Penadés

Faculty of MedicineDepartment of Infectious Disease

Director MRC Centre for Molecular Bacteriology & Infection
 
 
 
//

Contact

 

+44 (0)20 7594 8533j.penades Website

 
 
//

Assistant

 

Mrs Anna Lee +44 (0)20 7594 2954

 
//

Location

 

Flowers buildingSouth Kensington Campus

//

Summary

 

Publications

Publication Type
Year
to

128 results found

Perez MM, Prenafeta A, Valle J, Penades J, Rota C, Solano C, Marco J, Grillo MJ, Lasa I, Irache JM, Maira-Litran T, Jimenez-Barbero J, Costa L, Pier GB, de Andres D, Amorena Bet al., 2009, Protection from <i>Staphylococcus aureus</i> mastitis associated with poly-<i>N</i>-acetyl β-1,6 glucosamine specific antibody production using biofilm-embedded bacteria, VACCINE, Vol: 27, Pages: 2379-2386, ISSN: 0264-410X

Journal article

Merino N, Toledo-Arana A, Vergara-Irigaray M, Valle J, Solano C, Calvo E, Antonio Lopez J, Foster TJ, Penades JR, Lasa Iet al., 2009, Protein A-Mediated Multicellular Behavior in <i>Staphylococcus aureus</i>, JOURNAL OF BACTERIOLOGY, Vol: 191, Pages: 832-843, ISSN: 0021-9193

Journal article

Selva L, Viana D, Regev-Yochay G, Trzcinski K, Corpa JM, Lasa I, Novick RP, Penades JRet al., 2009, Killing niche competitors by remote-control bacteriophage induction, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 106, Pages: 1234-1238, ISSN: 0027-8424

Journal article

Angeles Tormo M, Desamparados Ferrer M, Maiques E, Ubeda C, Selva L, Lasa I, Calvete JJ, Novick RP, Penades JRet al., 2008, <i>Staphylococcus aureus</i> pathogenicity island DNA is packaged in particles composed of phage proteins, JOURNAL OF BACTERIOLOGY, Vol: 190, Pages: 2434-2440, ISSN: 0021-9193

Journal article

Vergara-Irigaray M, Maira-Litran T, Merino N, Pier GB, Penades JR, Lasa Iet al., 2008, Wall teichoic acids are dispensable for anchoring the PNAG exopolysaccharide to the <i>Staphylococcus aureus</i> cell surface, MICROBIOLOGY-SGM, Vol: 154, Pages: 865-877, ISSN: 1350-0872

Journal article

Ubeda C, Maiques E, Barry P, Matthews A, Tormo MA, Lasa I, Novick RP, Penades JRet al., 2008, SaPI mutations affecting replication and transfer and enabling autonomous replication in the absence of helper phage, MOLECULAR MICROBIOLOGY, Vol: 67, Pages: 493-503, ISSN: 0950-382X

Journal article

Subedi A, Ubeda C, Adhikari RP, Penades JR, Novick RPet al., 2007, Sequence analysis reveals genetic exchanges and intraspecific spread of SaP12, a pathogenicity island involved in menstrual toxic shock, MICROBIOLOGY-SGM, Vol: 153, Pages: 3235-3245, ISSN: 1350-0872

Journal article

Ubeda C, Barry P, Penades JR, Novick RPet al., 2007, A pathogenicity island replicon in <i>Staphylococcus aureus</i> replicates as an unstable plasmid, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 104, Pages: 14182-14188, ISSN: 0027-8424

Journal article

Del Pozo JL, Alonso M, Arciola CR, Gonzalez R, Leiva J, Lasa I, Penades Jet al., 2007, Biotechnological war against biofilms. Could phages mean the end of device-related infections?, INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, Vol: 30, Pages: 805-812, ISSN: 0391-3988

Journal article

Maiques E, Ubeda C, Tormo MA, Ferrer MD, Lasa I, Novick RP, Penades JRet al., 2007, Role of staphylococcal phage and SaPI integrase in intra- and interspecies SaPI transfer, JOURNAL OF BACTERIOLOGY, Vol: 189, Pages: 5608-5616, ISSN: 0021-9193

Journal article

Ubeda C, Maiques E, Tormo MA, Campoy S, Lasa I, Barbe J, Novick RP, Penades JRet al., 2007, SaPI operon I is required for SaPI packaging and is controlled by LexA, MOLECULAR MICROBIOLOGY, Vol: 65, Pages: 41-50, ISSN: 0950-382X

Journal article

Segura P, Martinez J, Peris B, Selva L, Viana D, Penades JR, Corpa JMet al., 2007, Staphylococcal infections in rabbit does on two industrial farms, VETERINARY RECORD, Vol: 160, Pages: 869-873, ISSN: 0042-4900

Journal article

Angeles Tormo M, Ubeda C, Marti M, Maiques E, Cucarella C, Valle J, Foster TJ, Lasa I, Penades JRet al., 2007, Phase-variable expression of the biofilm-associated protein (Bap) in <i>Staphylococcus aureus</i>, MICROBIOLOGY-SGM, Vol: 153, Pages: 1702-1710, ISSN: 1350-0872

Journal article

Viana D, Selva L, Segura P, Penades JR, Corpa JMet al., 2007, Genotypic characterization of <i>Staphylococcus aureus</i> strains isolated from rabbit lesions, VETERINARY MICROBIOLOGY, Vol: 121, Pages: 288-298, ISSN: 0378-1135

Journal article

Valle J, Vergara-Irigaray M, Merino N, Penades JR, Lasa Iet al., 2007, σ<SUP>B</SUP> regulates IS256-mediated <i>Staphylococcus aureus</i> biofilm phenotypic variationv, JOURNAL OF BACTERIOLOGY, Vol: 189, Pages: 2886-2896, ISSN: 0021-9193

Journal article

Latasa C, Solano C, Penades JR, Lasa Iet al., 2006, Biofilm-associated proteins, COMPTES RENDUS BIOLOGIES, Vol: 329, Pages: 849-857, ISSN: 1631-0691

Journal article

Maiques E, Ubeda C, Campoy S, Salvador N, Lasa I, Novick RP, Barbé J, Penadés JRet al., 2006, β-lactam antibiotics induce the SOS response and horizontal transfer of virulence factors in <i>Staphylococcus aureus</i>, JOURNAL OF BACTERIOLOGY, Vol: 188, Pages: 2726-2729, ISSN: 0021-9193

Journal article

Del Pozo JL, Serrera A, Martinez-Cuesta A, Leiva J, Penades J, Lasa Iet al., 2006, Biofilm related infections:: Is there a place for conservative treatment of port-related bloodstream infections?, INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, Vol: 29, Pages: 379-386, ISSN: 0391-3988

Journal article

Lasa I, Penadés JR, 2006, Bap:: A family of surface proteins involved in biofilm formation, RESEARCH IN MICROBIOLOGY, Vol: 157, Pages: 99-107, ISSN: 0923-2508

Journal article

Latasa C, Roux A, Toledo-Arana A, Ghigo JM, Gamazo C, Penadés JR, Lasa Iet al., 2005, BapA, a large secreted protein required for biofilm formation and host colonization of <i>Salmonella enterica</i> serovar Enteritidis, MOLECULAR MICROBIOLOGY, Vol: 58, Pages: 1322-1339, ISSN: 0950-382X

Journal article

Toledo-Arana A, Merino N, Vergara-Irigaray M, Déarbouillé M, Penadés JR, Lasa Het al., 2005, <i>Staphylococcus aureus</i> develops an alternative, <i>ica</i>-independent biofilm in the absence of the <i>arlRS</i> two-component system, JOURNAL OF BACTERIOLOGY, Vol: 187, Pages: 5318-5329, ISSN: 0021-9193

Journal article

Trotonda MP, Manna AC, Cheung AL, Lasa I, Penadés JRet al., 2005, SarA positively controls bap-dependent biofilm formation in <i>Staphylococcus aureus</i>, JOURNAL OF BACTERIOLOGY, Vol: 187, Pages: 5790-5798, ISSN: 0021-9193

Journal article

Tormo MA, Knecht E, Götz F, Lasa M, Penadés JRet al., 2005, Bap-dependent biofilm formation by pathogenic species of <i>Staphylococcus</i>:: evidence of horizontal gene transfer?, MICROBIOLOGY-SGM, Vol: 151, Pages: 2465-2475, ISSN: 1350-0872

Journal article

Ubeda C, Maiques E, Knecht E, Lasa I, Novick RP, Penadés JRet al., 2005, Antibiotic-induced SOS response promotes horizontal dissemination of pathogenicity island-encoded virulence factors in staphylococci, MOLECULAR MICROBIOLOGY, Vol: 56, Pages: 836-844, ISSN: 0950-382X

Journal article

Tormo MA, Martí M, Valle J, Manna AC, Cheung AL, Lasa I, Penadés JRet al., 2005, SarA is an essential positive regulator of <i>Staphylococcus epidermidis</i> biofilm development, JOURNAL OF BACTERIOLOGY, Vol: 187, Pages: 2348-2356, ISSN: 0021-9193

Journal article

Lasa I, Del Pozo JL, Penadés JR, Leiva Jet al., 2005, [Bacterial biofilms and infection]., An Sist Sanit Navar, Vol: 28, Pages: 163-175, ISSN: 1137-6627

In developed countries we tend to think of heart disease and the numerous forms of cancer as the main causes of mortality, but on a global scale infectious diseases come close, or may even be ahead: 14.9 million deaths in 2002 compared to cardiovascular diseases (16.9 million deaths) and cancer (7.1 million deaths) (WHO report 2004). The infectious agents responsible for human mortality have evolved as medical techniques and hygienic measures have changed. Modern-day acute infectious diseases caused by specialized bacterial pathogens such as diphtheria, tetanus, cholera, plague, which represented the main causes of death at the beginning of XX century, have been effectively controlled with antibiotics and vaccines. In their place, more than half of the infectious diseases that affect mildly immunocompromised patients involve bacterial species that are commensal with the human body; these can produce chronic infections, are resistant to antimicrobial agents and there is no effective vaccine against them. Examples of these infections are the otitis media, native valve endocarditis, chronic urinary infections, bacterial prostatitis, osteomyelitis and all the infections related to medical devices. Direct analysis of the surface of medical devices or of tissues that have been foci of chronic infections shows the presence of large numbers of bacteria surrounded by an exopolysaccharide matrix, which has been named the "biofilm". Inside the biofilm, bacteria grow protected from the action of the antibodies, phagocytic cells and antimicrobial treatments. In this article, we describe the role of bacterial biofilms in human persistent infections.

Journal article

Arrizubieta MJ, Toledo-Arana A, Amorena B, Penadés JR, Lasa Iet al., 2004, Calcium inhibits bap-dependent multicellular behavior in S<i>taphylococcus aureus</i>, JOURNAL OF BACTERIOLOGY, Vol: 186, Pages: 7490-7498, ISSN: 0021-9193

Journal article

Cucarella C, Tormo MA, Ubeda C, Trotonda MP, Monzón M, Peris C, Amorena B, Lasa I, Penadés JRet al., 2004, Role of biofilm-associated protein bap in the pathogenesis of bovine <i>Staphylococcus aureus</i>, INFECTION AND IMMUNITY, Vol: 72, Pages: 2177-2185, ISSN: 0019-9567

Journal article

Ubeda C, Tormo MA, Cucarella C, Trotonda P, Foster TJ, Lasa I, Penadés JRet al., 2003, Sip, an integrase protein with excision, circularization and integration activities, defines a new family of mobile <i>Staphylococcus aureus</i> pathogenicity islands, MOLECULAR MICROBIOLOGY, Vol: 49, Pages: 193-210, ISSN: 0950-382X

Journal article

Valle J, Toledo-Arana A, Berasain C, Ghigo JM, Amorena B, Penadés JR, Lasa Iet al., 2003, SarA and not σ<SUP>B</SUP> is essential for biofilm development by <i>Staphylococcus aureus</i>, MOLECULAR MICROBIOLOGY, Vol: 48, Pages: 1075-1087, ISSN: 0950-382X

Journal article

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wlsprd.imperial.ac.uk:80/respub/WEB-INF/jsp/search-html.jsp Request URI: /respub/WEB-INF/jsp/search-html.jsp Query String: id=01058143&limit=30&person=true&page=4&respub-action=search.html