Imperial College London
Portrait Picture

Professor José R Penadés

Faculty of Medicine, Department of Infectious Disease

Director MRC Centre for Molecular Bacteriology & Infection
 
 
 
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Contact

 

+44 (0)20 7594 8533j.penades Website

 
 
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Assistant

 

Mrs Anna Lee +44 (0)20 7594 2954

 
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Location

 

Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bacigalupe:2019:10.1126/sciadv.aax0063,
author = {Bacigalupe, R and Angeles, Tormo-Mas M and Penades, JR and Fitzgerald, JR},
doi = {10.1126/sciadv.aax0063},
journal = {Science Advances},
title = {A multihost bacterial pathogen overcomes continuous population bottlenecks to adapt to new host species},
url = {http://dx.doi.org/10.1126/sciadv.aax0063},
volume = {5},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - While many bacterial pathogens are restricted to single host species, some have the capacity to undergo host switches, leading to the emergence of new clones that are a threat to human and animal health. However, the bacterial traits that underpin a multihost ecology are not well understood. Following transmission to a new host, bacterial populations are influenced by powerful forces such as genetic drift that reduce the fixation rate of beneficial mutations, limiting the capacity for host adaptation. Here, we implement a novel experimental model of bacterial host switching to investigate the ability of the multihost pathogen Staphylococcus aureus to adapt to new species under continuous population bottlenecks. We demonstrate that beneficial mutations accumulated during infection can overcome genetic drift and sweep through the population, leading to host adaptation. Our findings highlight the remarkable capacity of some bacteria to adapt to distinct host niches in the face of powerful antagonistic population forces.
AU  - Bacigalupe,R
AU  - Angeles,Tormo-Mas M
AU  - Penades,JR
AU  - Fitzgerald,JR
DO  - 10.1126/sciadv.aax0063
PY  - 2019///
SN  - 2375-2548
TI  - A multihost bacterial pathogen overcomes continuous population bottlenecks to adapt to new host species
T2  - Science Advances
UR  - http://dx.doi.org/10.1126/sciadv.aax0063
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000499736100030&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/80426
VL  - 5
ER  -
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