Imperial College London
Portrait Picture

Professor José R Penadés

Faculty of Medicine, Department of Infectious Disease

Director MRC Centre for Molecular Bacteriology & Infection
 
 
 
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Contact

 

+44 (0)20 7594 8533j.penades Website

 
 
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Assistant

 

Mrs Anna Lee +44 (0)20 7594 2954

 
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Location

 

Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bowring:2017:10.7554/eLife.26487,
author = {Bowring, J and Neamah, MM and Donderis, J and Mir-Sanchis, I and Alite, C and Ciges-Tomas, JR and Maiques, E and Medmedov, I and Marina, A and Penadés, JR},
doi = {10.7554/eLife.26487},
journal = {eLife},
title = {Pirating conserved phage mechanisms promotes promiscuous staphylococcal pathogenicity island transfer},
url = {http://dx.doi.org/10.7554/eLife.26487},
volume = {6},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Targeting conserved and essential processes is a successful strategy to combat enemies. Remarkably, the clinically important Staphylococcus aureus pathogenicity islands (SaPIs) use this tactic to spread in nature. SaPIs reside passively in the host chromosome, under the control of the SaPI-encoded master repressor, Stl. It has been assumed that SaPI de-repression is effected by specific phage proteins that bind to Stl, initiating the SaPI cycle. Different SaPIs encode different Stl repressors, so each targets a specific phage protein for its de-repression. Broadening this narrow vision, we report here that SaPIs ensure their promiscuous transfer by targeting conserved phage mechanisms. This is accomplished because the SaPI Stl repressors have acquired different domains to interact with unrelated proteins, encoded by different phages, but in all cases performing the same conserved function. This elegant strategy allows intra- and inter-generic SaPI transfer, highlighting these elements as one of nature's most fascinating subcellular parasites.
AU  - Bowring,J
AU  - Neamah,MM
AU  - Donderis,J
AU  - Mir-Sanchis,I
AU  - Alite,C
AU  - Ciges-Tomas,JR
AU  - Maiques,E
AU  - Medmedov,I
AU  - Marina,A
AU  - Penadés,JR
DO  - 10.7554/eLife.26487
PY  - 2017///
SN  - 2050-084X
TI  - Pirating conserved phage mechanisms promotes promiscuous staphylococcal pathogenicity island transfer
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.26487
UR  - https://www.ncbi.nlm.nih.gov/pubmed/28826473
UR  - http://hdl.handle.net/10044/1/80400
VL  - 6
ER  -
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