Imperial College London
Portrait Picture

Professor José R Penadés

Faculty of Medicine, Department of Infectious Disease

Director MRC Centre for Molecular Bacteriology & Infection
 
 
 
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Contact

 

+44 (0)20 7594 8533j.penades Website

 
 
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Assistant

 

Mrs Anna Lee +44 (0)20 7594 2954

 
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Location

 

Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Carpena:2016:10.1098/rstb.2015.0505,
author = {Carpena, N and Manning, KA and Dokland, T and Marina, A and Penades, JR},
doi = {10.1098/rstb.2015.0505},
journal = {Philosophical Transactions of the Royal Society B: Biological Sciences},
title = {Convergent evolution of pathogenicity islands in helper cos phage interference},
url = {http://dx.doi.org/10.1098/rstb.2015.0505},
volume = {371},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Staphylococcus aureus pathogenicity islands (SaPIs) are phage satellites that exploit the life cycle of their helper phages for their own benefit. Most SaPIs are packaged by their helper phages using a headful (pac) packaging mechanism. These SaPIs interfere with pac phage reproduction through a variety of strategies, including the redirection of phage capsid assembly to form small capsids, a process that depends on the expression of the SaPI-encoded cpmA and cpmB genes. Another SaPI subfamily is induced and packaged by cos-type phages, and although these cos SaPIs also block the life cycle of their inducing phages, the basis for this mechanism of interference remains to be deciphered. Here we have identified and characterized one mechanism by which the SaPIs interfere with cos phage reproduction. This mechanism depends on a SaPI-encoded gene, ccm, which encodes a protein involved in the production of small isometric capsids, compared with the prolate helper phage capsids. As the Ccm and CpmAB proteins are completely unrelated in sequence, this strategy represents a fascinating example of convergent evolution. Moreover, this result also indicates that the production of SaPI-sized particles is a widespread strategy of phage interference conserved during SaPI evolution.
AU  - Carpena,N
AU  - Manning,KA
AU  - Dokland,T
AU  - Marina,A
AU  - Penades,JR
DO  - 10.1098/rstb.2015.0505
PY  - 2016///
SN  - 0962-8436
TI  - Convergent evolution of pathogenicity islands in helper cos phage interference
T2  - Philosophical Transactions of the Royal Society B: Biological Sciences
UR  - http://dx.doi.org/10.1098/rstb.2015.0505
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000385338300015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/80396
VL  - 371
ER  -
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