Imperial College London
Portrait Picture

Professor José R Penadés

Faculty of Medicine, Department of Infectious Disease

Director MRC Centre for Molecular Bacteriology & Infection
 
 
 
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Contact

 

+44 (0)20 7594 8533j.penades Website

 
 
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Assistant

 

Mrs Anna Lee +44 (0)20 7594 2954

 
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Location

 

Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Villanueva:2018:10.1038/s41467-018-02949-y,
author = {Villanueva, M and Garcia, B and Valle, J and Rapun, B and Ruiz, de los Mozos I and Solano, C and Marti, M and Penades, JR and Toledo-Arana, A and Lasa, I},
doi = {10.1038/s41467-018-02949-y},
journal = {Nature Communications},
title = {Sensory deprivation in Staphylococcus aureus},
url = {http://dx.doi.org/10.1038/s41467-018-02949-y},
volume = {9},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Bacteria use two-component systems (TCSs) to sense and respond to environmental changes. The core genome of the major human pathogen Staphylococcus aureus encodes 16 TCSs, one of which (WalRK) is essential. Here we show that S. aureus can be deprived of its complete sensorial TCS network and still survive under growth arrest conditions similarly to wild-type bacteria. Under replicating conditions, however, the WalRK system is necessary and sufficient to maintain bacterial growth, indicating that sensing through TCSs is mostly dispensable for living under constant environmental conditions. Characterization of S. aureus derivatives containing individual TCSs reveals that each TCS appears to be autonomous and self-sufficient to sense and respond to specific environmental cues, although some level of cross-regulation between non-cognate sensor-response regulator pairs occurs in vivo. This organization, if confirmed in other bacterial species, may provide a general evolutionarily mechanism for flexible bacterial adaptation to life in new niches.
AU  - Villanueva,M
AU  - Garcia,B
AU  - Valle,J
AU  - Rapun,B
AU  - Ruiz,de los Mozos I
AU  - Solano,C
AU  - Marti,M
AU  - Penades,JR
AU  - Toledo-Arana,A
AU  - Lasa,I
DO  - 10.1038/s41467-018-02949-y
PY  - 2018///
SN  - 2041-1723
TI  - Sensory deprivation in Staphylococcus aureus
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-018-02949-y
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000424291600019&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/80405
VL  - 9
ER  -
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