Imperial College London
Portrait Picture

Professor José R Penadés

Faculty of Medicine, Department of Infectious Disease

Director MRC Centre for Molecular Bacteriology & Infection
 
 
 
//

Contact

 

+44 (0)20 7594 8533j.penades Website

 
 
//

Assistant

 

Mrs Anna Lee +44 (0)20 7594 2954

 
//

Location

 

Flowers buildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Chen:2018:10.1126/science.aat5867,
author = {Chen, J and Quiles-Puchalt, N and Chiang, YN and Bacigalupe, R and Fillol-Salom, A and Chee, MSJ and Fitzgerald, JR and Penades, JR},
doi = {10.1126/science.aat5867},
journal = {Science},
pages = {207--212},
title = {Genome hypermobility by lateral transduction},
url = {http://dx.doi.org/10.1126/science.aat5867},
volume = {362},
year = {2018}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Genetic transduction is a major evolutionary force that underlies bacterial adaptation. Here we report that the temperate bacteriophages of Staphylococcus aureus engage in a distinct form of transduction we term lateral transduction. Staphylococcal prophages do not follow the previously described excision-replication-packaging pathway but instead excise late in their lytic program. Here, DNA packaging initiates in situ from integrated prophages, and large metameric spans including several hundred kilobases of the S. aureus genome are packaged in phage heads at very high frequency. In situ replication before DNA packaging creates multiple prophage genomes so that lateral-transducing particles form during normal phage maturation, transforming parts of the S. aureus chromosome into hypermobile regions of gene transfer.
AU  - Chen,J
AU  - Quiles-Puchalt,N
AU  - Chiang,YN
AU  - Bacigalupe,R
AU  - Fillol-Salom,A
AU  - Chee,MSJ
AU  - Fitzgerald,JR
AU  - Penades,JR
DO  - 10.1126/science.aat5867
EP  - 212
PY  - 2018///
SN  - 0036-8075
SP  - 207
TI  - Genome hypermobility by lateral transduction
T2  - Science
UR  - http://dx.doi.org/10.1126/science.aat5867
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000447337200051&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://science.sciencemag.org/content/362/6411/207
VL  - 362
ER  -
Download