Imperial College London
Portrait Picture

Professor José R Penadés

Faculty of Medicine, Department of Infectious Disease

Director MRC Centre for Molecular Bacteriology & Infection
 
 
 
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Contact

 

+44 (0)20 7594 8533j.penades Website

 
 
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Assistant

 

Mrs Anna Lee +44 (0)20 7594 2954

 
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Location

 

Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Frigols:2015:10.1371/journal.pgen.1005609,
author = {Frigols, B and Quiles-Puchalt, N and Mir-Sanchis, I and Donderis, J and Elena, SF and Buckling, A and Novick, RP and Marina, A and Penades, JR},
doi = {10.1371/journal.pgen.1005609},
journal = {PLoS Genetics},
title = {Virus satellites drive viral evolution and ecology},
url = {http://dx.doi.org/10.1371/journal.pgen.1005609},
volume = {11},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Virus satellites are widespread subcellular entities, present both in eukaryotic and in prokaryotic cells. Their modus vivendi involves parasitism of the life cycle of their inducing helper viruses, which assures their transmission to a new host. However, the evolutionary and ecological implications of satellites on helper viruses remain unclear. Here, using staphylococcal pathogenicity islands (SaPIs) as a model of virus satellites, we experimentally show that helper viruses rapidly evolve resistance to their virus satellites, preventing SaPI proliferation, and SaPIs in turn can readily evolve to overcome phage resistance. Genomic analyses of both these experimentally evolved strains as well as naturally occurring bacteriophages suggest that the SaPIs drive the coexistence of multiple alleles of the phage-coded SaPI inducing genes, as well as sometimes selecting for the absence of the SaPI depressing genes. We report similar (accidental) evolution of resistance to SaPIs in laboratory phages used for Staphylococcus aureus typing and also obtain the same qualitative results in both experimental evolution and phylogenetic studies of Enterococcus faecalis phages and their satellites viruses. In summary, our results suggest that helper and satellite viruses undergo rapid coevolution, which is likely to play a key role in the evolution and ecology of the viruses as well as their prokaryotic hosts.
AU  - Frigols,B
AU  - Quiles-Puchalt,N
AU  - Mir-Sanchis,I
AU  - Donderis,J
AU  - Elena,SF
AU  - Buckling,A
AU  - Novick,RP
AU  - Marina,A
AU  - Penades,JR
DO  - 10.1371/journal.pgen.1005609
PY  - 2015///
SN  - 1553-7390
TI  - Virus satellites drive viral evolution and ecology
T2  - PLoS Genetics
UR  - http://dx.doi.org/10.1371/journal.pgen.1005609
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000364401600071&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/80393
VL  - 11
ER  -
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