Imperial College London
Portrait Picture

Professor José R Penadés

Faculty of Medicine, Department of Infectious Disease

Director MRC Centre for Molecular Bacteriology & Infection
 
 
 
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Contact

 

+44 (0)20 7594 8533j.penades Website

 
 
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Assistant

 

Mrs Anna Lee +44 (0)20 7594 2954

 
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Location

 

Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Haaber:2016:10.1038/ncomms13333,
author = {Haaber, J and Leisner, JJ and Cohn, MT and Catalan-Moreno, A and Nielsen, JB and Westh, H and Penades, JR and Ingmer, H},
doi = {10.1038/ncomms13333},
journal = {Nature Communications},
title = {Bacterial viruses enable their host to acquire antibiotic resistance genes from neighbouring cells},
url = {http://dx.doi.org/10.1038/ncomms13333},
volume = {7},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Prophages are quiescent viruses located in the chromosomes of bacteria. In the human pathogen, Staphylococcus aureus, prophages are omnipresent and are believed to be responsible for the spread of some antibiotic resistance genes. Here we demonstrate that release of phages from a subpopulation of S. aureus cells enables the intact, prophage-containing population to acquire beneficial genes from competing, phage-susceptible strains present in the same environment. Phage infection kills competitor cells and bits of their DNA are occasionally captured in viral transducing particles. Return of such particles to the prophage-containing population can drive the transfer of genes encoding potentially useful traits such as antibiotic resistance. This process, which can be viewed as ‘auto-transduction’, allows S. aureus to efficiently acquire antibiotic resistance both in vitro and in an in vivo virulence model (wax moth larvae) and enables it to proliferate under strong antibiotic selection pressure. Our results may help to explain the rapid exchange of antibiotic resistance genes observed in S. aureus.
AU  - Haaber,J
AU  - Leisner,JJ
AU  - Cohn,MT
AU  - Catalan-Moreno,A
AU  - Nielsen,JB
AU  - Westh,H
AU  - Penades,JR
AU  - Ingmer,H
DO  - 10.1038/ncomms13333
PY  - 2016///
SN  - 2041-1723
TI  - Bacterial viruses enable their host to acquire antibiotic resistance genes from neighbouring cells
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/ncomms13333
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000387059400001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/80397
VL  - 7
ER  -
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