Imperial College London
Portrait Picture

Professor José R Penadés

Faculty of Medicine, Department of Infectious Disease

Director MRC Centre for Molecular Bacteriology & Infection
 
 
 
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Contact

 

+44 (0)20 7594 8533j.penades Website

 
 
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Assistant

 

Mrs Anna Lee +44 (0)20 7594 2954

 
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Location

 

Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Brady:2021:10.1146/annurev-micro-033121-020757,
author = {Brady, A and Felipe-Ruiz, A and Gallego, Del Sol F and Marina, A and Quiles-Puchalt, N and Penadés, JR},
doi = {10.1146/annurev-micro-033121-020757},
journal = {Annual Review of Microbiology},
pages = {1--19},
title = {Molecular basis of lysis-lysogeny decisions in gram-positive phages.},
url = {http://dx.doi.org/10.1146/annurev-micro-033121-020757},
volume = {10},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Temperate bacteriophages (phages) are viruses of bacteria. Upon infection of a susceptible host, a temperate phage can establish either a lytic cycle that kills the host or a lysogenic cycle as a stable prophage. The life cycle pursued by an infecting temperate phage can have a significant impact not only on the individual host bacterium at the cellular level but also on bacterial communities and evolution in the ecosystem. Thus, understanding the decision processes of temperate phages is crucial. This review delves into the molecular mechanisms behind lysis-lysogeny decision-making in Gram-positive phages. We discuss a variety of molecular mechanisms and the genetic organization of these well-understood systems. By elucidating the strategies used by phages to make lysis-lysogeny decisions, we can improve our understanding of phage-host interactions, which is crucial for a variety of studies including bacterial evolution, community and ecosystem diversification, and phage therapeutics. Expected final online publication date for the Annual Review of Microbiology, Volume 75 is October 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
AU  - Brady,A
AU  - Felipe-Ruiz,A
AU  - Gallego,Del Sol F
AU  - Marina,A
AU  - Quiles-Puchalt,N
AU  - Penadés,JR
DO  - 10.1146/annurev-micro-033121-020757
EP  - 19
PY  - 2021///
SN  - 0066-4227
SP  - 1
TI  - Molecular basis of lysis-lysogeny decisions in gram-positive phages.
T2  - Annual Review of Microbiology
UR  - http://dx.doi.org/10.1146/annurev-micro-033121-020757
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34343015
UR  - https://www.annualreviews.org/doi/10.1146/annurev-micro-033121-020757
VL  - 10
ER  -
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