- We have discovered the most powerful mode of transduction described to date: lateral transduction (a).
- We have discovered a novel mechanism of phage-mediated DNA packaging, involving HNH proteins (b).
- We have implicated for the first time the cos phages in the transfer of pathogenicity island-encoded virulence genes (c).
- We have discovered and characterised the biology of a novel family of mobile genetic elements, the PICIs (phage-inducible chromosomal islands), present both in Gram-positive and Gram-negative bacteria, and have deciphered their mechanism of transfer (d, e, f, g, h).
- We have discovered that just a single natural nucleotide mutation is sufficient to radically alter the bacterial pathogen host tropism (i).
- We have discovered and extensively characterised BAP, a family of proteins, present both in Gram-positive and Gram-negative bacteria, involved in biofilm formation. Our reports proposed and demonstrated that these proteins are essential components of the biofilm matrix (j).
- We have demonstrated that the dimeric and trimeric dUTPase enzymes are signalling molecules, from phage to eukaryotes (k).
- We have implicated dUTP as a second messenger in this novel signalling pathway (k).