I am a UKRI Innovation Fellow at Health Data Research UK and Clinical Reader in Rheumatology. I moved to Imperial College as a Group Leader in 2019.
My group’s research lies at the interface of molecular epidemiology, computational biology and clinical medicine. Our focus is understanding the molecular and cellular basis of immune-mediated inflammatory diseases using a combination of genomics, transcriptomics and proteomics. We employ a wide range of techniques including longitudinal molecular profiling, polygenic risk scores, and Mendelian randomisation, leveraging both our own in-house datasets and also publically available resources (eg GWAS summary statistics, UK Biobank).
et al., 2023, Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets, Nature Immunology, Vol:24, ISSN:1529-2908, Pages:1540-1551
et al., 2023, An atlas of genetic scores to predict multi-omic traits, Nature, Vol:616, ISSN:0028-0836, Pages:123-131
et al., 2022, Multi-omics identify falling LRRC15 as a COVID-19 severity marker and persistent pro-thrombotic signals in convalescence, Nature Communications, Vol:13, ISSN:2041-1723
et al., 2021, Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19., Nat Med, Vol:27, Pages:668-676
et al., 2021, Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of death, Elife, Vol:10, ISSN:2050-084X
et al., 2020, Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals, Nature Metabolism, Vol:2, ISSN:2522-5812, Pages:1135-1148
et al., 2020, Novel approach to imaging active takayasu arteritis using somatostatin receptor positron emission tomography/magnetic resonance imaging., Circulation-Cardiovascular Imaging, Vol:13, ISSN:1941-9651, Pages:1-3
et al., 2019, Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status, Nature Communications, Vol:10, ISSN:2041-1723
et al., 2018, Reduced monocyte and macrophage TNFSF15/TL1A expression is associated with susceptibility to inflammatory bowel disease, PLOS Genetics, Vol:14, ISSN:1553-7390
et al., 2018, Genomic atlas of the human plasma proteome, Nature, Vol:558, ISSN:0028-0836, Pages:73-79
et al., 2016, Insight into genotype-phenotype associations through eQTL mapping in multiple cell types in health and immune-mediated disease, PLOS Genetics, Vol:12, ISSN:1553-7390, Pages:1-29