Imperial College London
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DrJamesPeters

Faculty of Medicine, Department of Immunology and Inflammation

Clinical Reader in Rheumatology
 
 
 
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j.peters

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sun:2018:10.1038/s41586-018-0175-2,
author = {Sun, BB and Maranville, JC and Peters, JE and Stacey, D and Staley, JR and Blackshaw, J and Burgess, S and Jiang, T and Paige, E and Surendran, P and Oliver-Williams, C and Kamat, MA and Prins, BP and Wilcox, SK and Zimmerman, ES and Chi, A and Bansal, N and Spain, SL and Wood, AM and Morrell, NW and Bradley, JR and Janjic, N and Roberts, DJ and Ouwehand, WH and Todd, JA and Soranzo, N and Suhre, K and Paul, DS and Fox, CS and Plenge, RM and Danesh, J and Runz, H and Butterworth, AS},
doi = {10.1038/s41586-018-0175-2},
journal = {Nature},
pages = {73--79},
title = {Genomic atlas of the human plasma proteome},
url = {http://dx.doi.org/10.1038/s41586-018-0175-2},
volume = {558},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Although plasma proteins have important roles in biological processes and are the direct targets of many drugs, the genetic factors that control inter-individual variation in plasma protein levels are not well understood. Here we characterize the genetic architecture of the human plasma proteome in healthy blood donors from the INTERVAL study. We identify 1,927 genetic associations with 1,478 proteins, a fourfold increase on existing knowledge, including trans associations for 1,104 proteins. To understand the consequences of perturbations in plasma protein levels, we apply an integrated approach that links genetic variation with biological pathway, disease, and drug databases. We show that protein quantitative trait loci overlap with gene expression quantitative trait loci, as well as with disease-associated loci, and find evidence that protein biomarkers have causal roles in disease using Mendelian randomization analysis. By linking genetic factors to diseases via specific proteins, our analyses highlight potential therapeutic targets, opportunities for matching existing drugs with new disease indications, and potential safety concerns for drugs under development.
AU  - Sun,BB
AU  - Maranville,JC
AU  - Peters,JE
AU  - Stacey,D
AU  - Staley,JR
AU  - Blackshaw,J
AU  - Burgess,S
AU  - Jiang,T
AU  - Paige,E
AU  - Surendran,P
AU  - Oliver-Williams,C
AU  - Kamat,MA
AU  - Prins,BP
AU  - Wilcox,SK
AU  - Zimmerman,ES
AU  - Chi,A
AU  - Bansal,N
AU  - Spain,SL
AU  - Wood,AM
AU  - Morrell,NW
AU  - Bradley,JR
AU  - Janjic,N
AU  - Roberts,DJ
AU  - Ouwehand,WH
AU  - Todd,JA
AU  - Soranzo,N
AU  - Suhre,K
AU  - Paul,DS
AU  - Fox,CS
AU  - Plenge,RM
AU  - Danesh,J
AU  - Runz,H
AU  - Butterworth,AS
DO  - 10.1038/s41586-018-0175-2
EP  - 79
PY  - 2018///
SN  - 0028-0836
SP  - 73
TI  - Genomic atlas of the human plasma proteome
T2  - Nature
UR  - http://dx.doi.org/10.1038/s41586-018-0175-2
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29875488
UR  - http://hdl.handle.net/10044/1/74897
VL  - 558
ER  -
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