Imperial College London
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DrJamesPeters

Faculty of Medicine, Department of Immunology and Inflammation

Clinical Reader in Rheumatology
 
 
 
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j.peters

 
 
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ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bell:2021:10.1038/s42003-020-01575-z,
author = {Bell, S and Rigas, AS and Magnusson, MK and Ferkingstad, E and Allara, E and Bjornsdottir, G and Ramond, A and Sorensen, E and Halldorsson, GH and Paul, DS and Eggertsson, HP and Burgdorf, KS and Howson, JMM and Thorner, LW and Kristmundsdottir, S and Astle, WJ and Erikstrup, C and Sigurdsson, JK and Vuckovic, D and Dinh, KM and Tragante, V and Surendran, P and Pedersen, OB and Vidarsson, B and Jiang, T and Paarup, HM and Onundarson, PT and Akbari, P and Nielsen, KR and Lund, SH and Juliusson, K and Magnusson, M and Frigge, ML and Oddsson, A and Olafsson, I and Kaptoge, S and Hjalgrim, H and Runarsson, G and Wood, AM and Jonsdottir, I and Hansen, TF and Sigurdardottir, O and Stefansson, H and Rye, D and Peters, JE and Westergaard, D and Holm, H and Soranzo, N and Banasik, K and Thorleifsson, G and Ouwehand, WH and Thorsteinsdottir, U and Roberts, DJ and Sulem, P and Butterworth, AS and Gudbjartsson, DF and Danesh, J and Brunak, S and Di, Angelantonio E and Ullum, H and Stefansson, K},
doi = {10.1038/s42003-020-01575-z},
journal = {Communications Biology},
pages = {1--14},
title = {A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis},
url = {http://dx.doi.org/10.1038/s42003-020-01575-z},
volume = {4},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Iron is essential for many biological functions and iron deficiency and overload have major health implications. We performed a meta-analysis of three genome-wide association studies from Iceland, the UK and Denmark of blood levels of ferritin (N = 246,139), total iron binding capacity (N = 135,430), iron (N = 163,511) and transferrin saturation (N = 131,471). We found 62 independent sequence variants associating with iron homeostasis parameters at 56 loci, including 46 novel loci. Variants at DUOX2, F5, SLC11A2 and TMPRSS6 associate with iron deficiency anemia, while variants at TF, HFE, TFR2 and TMPRSS6 associate with iron overload. A HBS1L-MYB intergenic region variant associates both with increased risk of iron overload and reduced risk of iron deficiency anemia. The DUOX2 missense variant is present in 14% of the population, associates with all iron homeostasis biomarkers, and increases the risk of iron deficiency anemia by 29%. The associations implicate proteins contributing to the main physiological processes involved in iron homeostasis: iron sensing and storage, inflammation, absorption of iron from the gut, iron recycling, erythropoiesis and bleeding/menstruation.
AU  - Bell,S
AU  - Rigas,AS
AU  - Magnusson,MK
AU  - Ferkingstad,E
AU  - Allara,E
AU  - Bjornsdottir,G
AU  - Ramond,A
AU  - Sorensen,E
AU  - Halldorsson,GH
AU  - Paul,DS
AU  - Eggertsson,HP
AU  - Burgdorf,KS
AU  - Howson,JMM
AU  - Thorner,LW
AU  - Kristmundsdottir,S
AU  - Astle,WJ
AU  - Erikstrup,C
AU  - Sigurdsson,JK
AU  - Vuckovic,D
AU  - Dinh,KM
AU  - Tragante,V
AU  - Surendran,P
AU  - Pedersen,OB
AU  - Vidarsson,B
AU  - Jiang,T
AU  - Paarup,HM
AU  - Onundarson,PT
AU  - Akbari,P
AU  - Nielsen,KR
AU  - Lund,SH
AU  - Juliusson,K
AU  - Magnusson,M
AU  - Frigge,ML
AU  - Oddsson,A
AU  - Olafsson,I
AU  - Kaptoge,S
AU  - Hjalgrim,H
AU  - Runarsson,G
AU  - Wood,AM
AU  - Jonsdottir,I
AU  - Hansen,TF
AU  - Sigurdardottir,O
AU  - Stefansson,H
AU  - Rye,D
AU  - Peters,JE
AU  - Westergaard,D
AU  - Holm,H
AU  - Soranzo,N
AU  - Banasik,K
AU  - Thorleifsson,G
AU  - Ouwehand,WH
AU  - Thorsteinsdottir,U
AU  - Roberts,DJ
AU  - Sulem,P
AU  - Butterworth,AS
AU  - Gudbjartsson,DF
AU  - Danesh,J
AU  - Brunak,S
AU  - Di,Angelantonio E
AU  - Ullum,H
AU  - Stefansson,K
DO  - 10.1038/s42003-020-01575-z
EP  - 14
PY  - 2021///
SN  - 2399-3642
SP  - 1
TI  - A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis
T2  - Communications Biology
UR  - http://dx.doi.org/10.1038/s42003-020-01575-z
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000617687000002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/s42003-020-01575-z
UR  - http://hdl.handle.net/10044/1/87856
VL  - 4
ER  -
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