Imperial College London
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Dr Joram M. Posma PhD MSc B AS MRSC

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Senior Lecturer in Biomedical Informatics
 
 
 
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Contact

 

j.posma11 Website

 
 
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Location

 

E305Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jordi:2021:10.1002/mnfr.202001018,
author = {Jordi, M-P and Wellington, A and Lubach, G and Posma, J and Coe, C and Swann, J},
doi = {10.1002/mnfr.202001018},
journal = {Molecular Nutrition and Food Research},
title = {Gut microbial and metabolic profiling reveal the lingering effects of infantile iron deficiency unless treated with iron},
url = {http://dx.doi.org/10.1002/mnfr.202001018},
volume = {65},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ScopeIron deficiency (ID) compromises the health of infants worldwide. Although readily treated with iron, concerns remain about the persistence of some effects. Metabolic and gut microbial consequences of infantile ID were investigated in juvenile monkeys after natural recovery (pID) from iron deficiency or posttreatment with iron dextran and B vitamins (pID+Fe).Methods and ResultsMetabolomic profiling of urine and plasma is conducted with 1H nuclear magnetic resonance (NMR) spectroscopy. Gut microbiota are characterized from rectal swabs by amplicon sequencing of the 16S rRNA gene. Urinary metabolic profiles of pID monkeys significantly differed from pID+Fe and continuously ironsufficient controls (IS) with higher maltose and lower amounts of microbialderived metabolites. Persistent differences in energy metabolism are apparent from the plasma metabolic phenotypes with greater reliance on anaerobic glycolysis in pID monkeys. Microbial profiling indicated higher abundances of Methanobrevibacter, Lachnobacterium, and Ruminococcus in pID monkeys and any history of ID resulted in a lower Prevotella abundance compared to the IS controls.ConclusionsLingering metabolic and microbial effects are found after natural recovery from ID. These longterm biochemical derangements are not present in the pID+Fe animals emphasizing the importance of the early detection and treatment of earlylife ID to ameliorate its chronic metabolic effects.
AU  - Jordi,M-P
AU  - Wellington,A
AU  - Lubach,G
AU  - Posma,J
AU  - Coe,C
AU  - Swann,J
DO  - 10.1002/mnfr.202001018
PY  - 2021///
SN  - 1613-4125
TI  - Gut microbial and metabolic profiling reveal the lingering effects of infantile iron deficiency unless treated with iron
T2  - Molecular Nutrition and Food Research
UR  - http://dx.doi.org/10.1002/mnfr.202001018
UR  - http://hdl.handle.net/10044/1/87555
VL  - 65
ER  -
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