Imperial College London
Portrait Picture

Dr Joram M. Posma PhD MSc B AS MRSC

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Senior Lecturer in Biomedical Informatics
 
 
 
//

Contact

 

j.posma11 Website

 
 
//

Location

 

E305Burlington DanesHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{O'Keefe:2015:10.1038/ncomms7342,
author = {O'Keefe, SJ and Li, JV and Lahti, L and Ou, J and Carbonero, F and Mohammed, K and Posma, JM and Kinross, J and Wahl, E and Ruder, E and Vipperla, K and Naidoo, V and Mtshali, L and Tims, S and Puylaert, PG and DeLany, J and Krasinskas, A and Benefiel, AC and Kaseb, HO and Newton, K and Nicholson, JK and de, Vos WM and Gaskins, HR and Zoetendal, EG},
doi = {10.1038/ncomms7342},
journal = {Nature Communications},
pages = {1--14},
title = {Fat, fibre and cancer risk in African Americans and rural Africans},
url = {http://dx.doi.org/10.1038/ncomms7342},
volume = {6},
year = {2015}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Rates of colon cancer are much higher in African Americans (65:100,000) than in rural South Africans (<5:100,000). The higher rates are associated with higher animal protein and fat, and lower fibre consumption, higher colonic secondary bile acids, lower colonic short-chain fatty acid quantities and higher mucosal proliferative biomarkers of cancer risk in otherwise healthy middle-aged volunteers. Here we investigate further the role of fat and fibre in this association. We performed 2-week food exchanges in subjects from the same populations, where African Americans were fed a high-fibre, low-fat African-style diet and rural Africans a high-fat, low-fibre western-style diet, under close supervision. In comparison with their usual diets, the food changes resulted in remarkable reciprocal changes in mucosal biomarkers of cancer risk and in aspects of the microbiota and metabolome known to affect cancer risk, best illustrated by increased saccharolytic fermentation and butyrogenesis, and suppressed secondary bile acid synthesis in the African Americans.
AU  - O'Keefe,SJ
AU  - Li,JV
AU  - Lahti,L
AU  - Ou,J
AU  - Carbonero,F
AU  - Mohammed,K
AU  - Posma,JM
AU  - Kinross,J
AU  - Wahl,E
AU  - Ruder,E
AU  - Vipperla,K
AU  - Naidoo,V
AU  - Mtshali,L
AU  - Tims,S
AU  - Puylaert,PG
AU  - DeLany,J
AU  - Krasinskas,A
AU  - Benefiel,AC
AU  - Kaseb,HO
AU  - Newton,K
AU  - Nicholson,JK
AU  - de,Vos WM
AU  - Gaskins,HR
AU  - Zoetendal,EG
DO  - 10.1038/ncomms7342
EP  - 14
PY  - 2015///
SN  - 2041-1723
SP  - 1
TI  - Fat, fibre and cancer risk in African Americans and rural Africans
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/ncomms7342
UR  - http://www.ncbi.nlm.nih.gov/pubmed/25919227
UR  - https://www.nature.com/articles/ncomms7342
UR  - http://hdl.handle.net/10044/1/78810
VL  - 6
ER  -
Download