Imperial College London
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MrJamesPotts

Faculty of Medicine, National Heart & Lung Institute

Statistician/Data Manager
 
 
 
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Contact

 

+44 (0)20 7594 7953j.potts

 
 
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Location

 

G61Emmanuel Kaye BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Garcia:2018:10.1038/s41430-018-0234-7,
author = {Garcia, Larsen V and Morton, V and Norat, T and Moreira, A and Potts, J and Bakolis, I},
doi = {10.1038/s41430-018-0234-7},
journal = {European Journal of Clinical Nutrition},
pages = {366--386},
title = {Dietary patterns derived from Principal Component Analysis (PCA) and the risk of colorectal cancer: a systematic review and meta-analysis},
url = {http://dx.doi.org/10.1038/s41430-018-0234-7},
volume = {73},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background and aim: Colorectal cancer [CRC] is highly prevalent worldwide, with dietary habits being a major risk factor. We systematically reviewed and meta-analysed the observational evidence on the association between CRC and dietary patterns [DP] derived from Principal Component Analysis.Design: PRISMA guidelines were followed. Web of Science, Medline/PubMed, EMBASE, and The Cochrane Library were searched to identify all eligible papers published up to July 2017. Any pre-defined cancer in the colon was included, namely colon-rectal cancer (CRC), colon cancer (CC), rectal cancer (RC), or proximal and distal CC, if available.  Western (WDP) and prudent (PDP) dietary patterns were compared as a proxy to estimate ‘unhealthy’ (Rich in meat and processed foods) and ‘healthy’ diets (containing fruits or vegetables), respectively. Meta-analyses were carried out using random effects model to calculate overall risk estimates.  Relative risks (RR) and 95% confidence intervals were estimated comparing the highest versus the lowest categories of dietary patterns for any of the forms of colon cancer studied.Results: 28 studies were meta-analysed. A WDP was associated with increased risk of CRC (RR 1.25; 95% CI 1.11, 1.40), and of CC (RR 1.30; 95% CI 1.11, 1.52).  A PDP was negatively associated with CRC (RR 0.81; 95% CI 0.73, 0.91). Sensitivity analyses showed that individuals from North- and South- American countries had a significantly higher risk of CRC than those from other continents. Conclusion: A PDP might reduce the risk of CRC. Conversely, a WDP is associated with a higher risk of disease.
AU  - Garcia,Larsen V
AU  - Morton,V
AU  - Norat,T
AU  - Moreira,A
AU  - Potts,J
AU  - Bakolis,I
DO  - 10.1038/s41430-018-0234-7
EP  - 386
PY  - 2018///
SN  - 1476-5640
SP  - 366
TI  - Dietary patterns derived from Principal Component Analysis (PCA) and the risk of colorectal cancer: a systematic review and meta-analysis
T2  - European Journal of Clinical Nutrition
UR  - http://dx.doi.org/10.1038/s41430-018-0234-7
UR  - http://hdl.handle.net/10044/1/60314
VL  - 73
ER  -
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