Publications

BibTex format

@article{Knox-Brown:2023:10.1186/s12931-023-02450-1,
author = {Knox-Brown, B and Patel, J and Potts, J and Ahmed, R and Aquart-Stewart, A and Barbara, C and Buist, AS and Cherkaski, HH and Denguezli, M and Elbiaze, M and Erhabor, G and Franssen, F and Al, Ghobain M and Gislasson, T and Janson, C and Kocabas, A and Mannino, D and Marks, G and Mortimer, K and Nafees, AA and Obaseki, D and Paraguas, S and Loh, LC and Rashid, A and Salvi, S and Seemungal, T and Studnicka, M and Tan, W and Wouters, E and Abozid, H and Mueller, A and Burney, P and Amaral, A},
doi = {10.1186/s12931-023-02450-1},
journal = {Respiratory Research},
title = {The association of spirometric small airways obstruction with respiratory symptoms, cardiometabolic diseases, and quality of life: Results from the Burden of Obstructive Lung Disease (BOLD) study},
url = {http://dx.doi.org/10.1186/s12931-023-02450-1},
volume = {24},
year = {2023}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background:Spirometric small airways obstruction (SAO) is common in the general population. Whether spirometric SAO is associated with respiratory symptoms, cardiometabolic diseases, and quality of life (QoL) is unknown.Methods:Using data from the Burden of Obstructive Lung Disease study (N = 21,594), we defined spirometric SAO as the mean forced expiratory flow rate between 25 and 75% of the FVC (FEF25-75) less than the lower limit of normal (LLN) or the forced expiratory volume in 3 s to FVC ratio (FEV3/FVC) less than the LLN. We analysed data on respiratory symptoms, cardiometabolic diseases, and QoL collected using standardised questionnaires. We assessed the associations with spirometric SAO using multivariable regression models, and pooled site estimates using random effects meta-analysis. We conducted identical analyses for isolated spirometric SAO (i.e. with FEV1/FVC ≥ LLN).Results:Almost a fifth of the participants had spirometric SAO (19% for FEF25-75; 17% for FEV3/FVC). Using FEF25-75, spirometric SAO was associated with dyspnoea (OR = 2.16, 95% CI 1.77–2.70), chronic cough (OR = 2.56, 95% CI 2.08–3.15), chronic phlegm (OR = 2.29, 95% CI 1.77–4.05), wheeze (OR = 2.87, 95% CI 2.50–3.40) and cardiovascular disease (OR = 1.30, 95% CI 1.11–1.52), but not hypertension or diabetes. Spirometric SAO was associated with worse physical and mental QoL. These associations were similar for FEV3/FVC. Isolated spirometric SAO (10% for FEF25-75; 6% for FEV3/FVC), was also associated with respiratory symptoms and cardiovascular disease.Conclusion:Spirometric SAO is associated with respiratory symptoms, cardiovascular disease, and QoL. Consideration should be given to the measurement of FEF25-75 and FEV3/FVC, in addition to traditional spirometry parameters.
AU  - Knox-Brown,B
AU  - Patel,J
AU  - Potts,J
AU  - Ahmed,R
AU  - Aquart-Stewart,A
AU  - Barbara,C
AU  - Buist,AS
AU  - Cherkaski,HH
AU  - Denguezli,M
AU  - Elbiaze,M
AU  - Erhabor,G
AU  - Franssen,F
AU  - Al,Ghobain M
AU  - Gislasson,T
AU  - Janson,C
AU  - Kocabas,A
AU  - Mannino,D
AU  - Marks,G
AU  - Mortimer,K
AU  - Nafees,AA
AU  - Obaseki,D
AU  - Paraguas,S
AU  - Loh,LC
AU  - Rashid,A
AU  - Salvi,S
AU  - Seemungal,T
AU  - Studnicka,M
AU  - Tan,W
AU  - Wouters,E
AU  - Abozid,H
AU  - Mueller,A
AU  - Burney,P
AU  - Amaral,A
DO  - 10.1186/s12931-023-02450-1
PY  - 2023///
SN  - 1465-9921
TI  - The association of spirometric small airways obstruction with respiratory symptoms, cardiometabolic diseases, and quality of life: Results from the Burden of Obstructive Lung Disease (BOLD) study
T2  - Respiratory Research
UR  - http://dx.doi.org/10.1186/s12931-023-02450-1
UR  - http://hdl.handle.net/10044/1/104567
VL  - 24
ER  -

Download

MrJamesPotts

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)