Imperial College London
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MrJamesPotts

Faculty of Medicine, National Heart & Lung Institute

Statistician/Data Manager
 
 
 
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Contact

 

+44 (0)20 7594 7953j.potts

 
 
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Location

 

G61Emmanuel Kaye BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Fedorova:2017:10.1111/all.13120,
author = {Fedorova, OS and Janse, JJ and Ogorodova, LM and Fedotova, MM and Achterberg, RA and Verweij, JJ and Fernández-Rivas, M and Versteeg, SA and Potts, J and Minelli, C and van, Ree R and Burney, P and Yazdanbakhsh, M},
doi = {10.1111/all.13120},
journal = {Allergy},
pages = {1096--1104},
title = {Opisthorchis felineus negatively associates with skin test reactivity in Russia-EuroPrevall-International Cooperation study},
url = {http://dx.doi.org/10.1111/all.13120},
volume = {72},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Most studies on the relationship between helminth infections and atopic disorders have been conducted in (sub)tropical developing countries where exposure to multiple parasites and lifestyle can confound the relationship. We aimed to study the relationship between infection with the fish-borne helminth Opishorchis felineus and specific IgE, skin prick testing, and atopic symptoms in Western Siberia, with lifestyle and hygiene standards of a developed country. METHODS: Schoolchildren aged 7-11 years were sampled from one urban and two rural regions. Skin prick tests (SPT) and specific IgE (sIgE) against food and aeroallergens were measured, and data on allergic symptoms and on demographic and socioeconomic factors were collected by questionnaire. Diagnosis of opisthorchiasis was based on PCR performed on stool samples. RESULTS: Of the 732 children included, 34.9% had opisthorchiasis. The sensitization to any allergen when estimated by positive SPT was 12.8%, while much higher, 24.0%, when measured by sIgE. Atopic symptoms in the past year (flexural eczema and/or rhinoconjunctivitis) were reported in 12.4% of the children. SPT was positively related to flexural eczema and rhinoconjunctivitis, but not to wheezing. Opisthorchiasis showed association with lower SPT response, as well as borderline association with low IgE reactivity to any allergen. However, the effect of opisthorchiasis on SPT response was not mediated by IgE, suggesting that opisthorchiasis influences SPT response through another mechanism. Opisthorchiasis also showed borderline association with lower atopic symptoms. CONCLUSIONS: There is a negative association between a chronic helminth infection and skin prick test reactivity even in a developed country.
AU  - Fedorova,OS
AU  - Janse,JJ
AU  - Ogorodova,LM
AU  - Fedotova,MM
AU  - Achterberg,RA
AU  - Verweij,JJ
AU  - Fernández-Rivas,M
AU  - Versteeg,SA
AU  - Potts,J
AU  - Minelli,C
AU  - van,Ree R
AU  - Burney,P
AU  - Yazdanbakhsh,M
DO  - 10.1111/all.13120
EP  - 1104
PY  - 2017///
SN  - 0105-4538
SP  - 1096
TI  - Opisthorchis felineus negatively associates with skin test reactivity in Russia-EuroPrevall-International Cooperation study
T2  - Allergy
UR  - http://dx.doi.org/10.1111/all.13120
UR  - http://www.ncbi.nlm.nih.gov/pubmed/28032359
UR  - http://hdl.handle.net/10044/1/44600
VL  - 72
ER  -
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