Publications

BibTex format

@article{Garcia-Larsen:2018:10.3390/nu10010095,
author = {Garcia-Larsen, V and Thawer, N and Charles, D and Cassidy, A and van, Zele T and Thilsing, T and Ahlström, M and Haahtela, T and Keil, T and Matricardi, PM and Brozek, G and Kowalski, ML and Makowska, J and Nizankowska-Mogilnicka, E and Rymarczyk, B and Loureiro, C and Todo, Bom A and Bachert, C and Forsberg, B and Janson, C and Torén, K and Potts, JF and Burney, PGJ},
doi = {10.3390/nu10010095},
journal = {Nutrients},
title = {Dietary Intake of Flavonoids and Ventilatory Function in European Adults: A GA2LEN Study},
url = {http://dx.doi.org/10.3390/nu10010095},
volume = {10},
year = {2018}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Flavonoids exert anti-inflammatory properties and modulate oxidative stress in vitro, suggesting a protective effect on lung function, but epidemiological studies examining this association are scarce. Methods: A stratified random sample was drawn from the GA2LEN screening survey, in which 55,000 adults aged 15 to 75 answered a questionnaire on respiratory symptoms. Post-bronchodilator spirometry was obtained from 2850 subjects. Forced vital capacity (FVC), the ratio between the forced exhaled volume in 1 second (FEV1) and FVC (FEV1/FVC), FVC below lower limit of normal (FVC < LLN), and FEV1/FVC < LLN were calculated. Intake of the six main subclasses of flavonoids was estimated using the GA2LEN Food Frequency Questionnaire. Adjusted associations between outcomes and each subclass of flavonoids were examined with multivariate regressions. Simes’ procedure was used to test for multiple comparisons. Results: A total of 2599 subjects had valid lung function and dietary data. A lower prevalence of FVC < LLN (airway restriction) was observed in those with higher total flavonoid (adjusted odds ratio (aOR), higher vs. lowest quintile intake 0.58; 95% Confidence Interval (CI) 0.36, 0.94), and pro-anthocyanidin intakes (aOR 0.47; 95% CI 0.27, 0.81). A higher FEV1/FVC was associated with higher intakes of total flavonoids and pro-anthocyanidins (adjusted correlation coefficient (a β-coeff 0.33; 0.10, 0.57 and a β-coeff 0.44; 95% CI 0.19, 0.69, respectively). After Simes’ procedure, the statistical significance of each of these associations was attenuated but remained below 0.05, with the exception of total flavonoids and airway restriction. Conclusions: This population-based study in European adults provides cross-sectional evidence of a positive association of total flavonoid intake and pro-anthocyanidins and ventilatory function, and a negative association with spirometric restriction in European adults.
AU  - Garcia-Larsen,V
AU  - Thawer,N
AU  - Charles,D
AU  - Cassidy,A
AU  - van,Zele T
AU  - Thilsing,T
AU  - Ahlström,M
AU  - Haahtela,T
AU  - Keil,T
AU  - Matricardi,PM
AU  - Brozek,G
AU  - Kowalski,ML
AU  - Makowska,J
AU  - Nizankowska-Mogilnicka,E
AU  - Rymarczyk,B
AU  - Loureiro,C
AU  - Todo,Bom A
AU  - Bachert,C
AU  - Forsberg,B
AU  - Janson,C
AU  - Torén,K
AU  - Potts,JF
AU  - Burney,PGJ
DO  - 10.3390/nu10010095
PY  - 2018///
SN  - 2072-6643
TI  - Dietary Intake of Flavonoids and Ventilatory Function in European Adults: A GA2LEN Study
T2  - Nutrients
UR  - http://dx.doi.org/10.3390/nu10010095
UR  - http://hdl.handle.net/10044/1/56491
VL  - 10
ER  -

Download

MrJamesPotts

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)