Imperial College London
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ProfessorJenniferQuint

Faculty of Medicine, School of Public Health

Professor of Respiratory Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 8821j.quint

 
 
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Location

 

.922Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gulea:2018:10.1136/bmjopen-2018-024736,
author = {Gulea, C and Zakeri, R and Quint, JK},
doi = {10.1136/bmjopen-2018-024736},
journal = {BMJ Open},
title = {Effect of beta-blocker therapy on clinical outcomes, safety, health-related quality of life and functional capacity in patients with chronic obstructive pulmonary disease (COPD): A protocol for a systematic literature review and meta-analysis with multiple treatment comparison},
url = {http://dx.doi.org/10.1136/bmjopen-2018-024736},
volume = {8},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - AbstractIntroductionPatients with chronic obstructive pulmonary disease (COPD) who have a clinical indication for beta-blocker therapy, are often not prescribed such medication, despite evidence suggesting that beta-blockers are not associated with adverse respiratory outcomes. The primary objective of this systematic review and meta-analysis is to examine the class effect of beta-blocker use in patients with COPD. We will focus on a broad range of endpoints including, clinical, safety, and patient-centric outcomes such as health related quality of life (HRQoL) and functional capacity. A secondary objective is to explore potential within-class variation in the effects of beta-blockers among patients with COPD, and rank individual agents according to their relative benefit(s). Methods and analysisMEDLINE, Embase The Cochrane Library and the Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases will be systematically searched, from inception to present, to identify randomised controlled trials (RCTs) and other prospective and interventional studies of beta-blocker use in patients with COPD, which report on the outcomes of interest. Relative treatment effects with respect to mortality, COPD exacerbations, all-cause hospitalisation, lung function, HRQoL and exercise capacity will be summarised by meta-analysis. Individual treatments (agents) will be compared in a Bayesian network meta-analysis (NMA) including RCT and observational data, if feasible.Ethics and disseminationThe results of the study will be submitted for publication in a peer-reviewed journal. Only previously published aggregate data will be used for the purpose of this review.
AU  - Gulea,C
AU  - Zakeri,R
AU  - Quint,JK
DO  - 10.1136/bmjopen-2018-024736
PY  - 2018///
SN  - 2044-6055
TI  - Effect of beta-blocker therapy on clinical outcomes, safety, health-related quality of life and functional capacity in patients with chronic obstructive pulmonary disease (COPD): A protocol for a systematic literature review and meta-analysis with multiple treatment comparison
T2  - BMJ Open
UR  - http://dx.doi.org/10.1136/bmjopen-2018-024736
UR  - http://hdl.handle.net/10044/1/65238
VL  - 8
ER  -
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