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@article{Requena:2021:10.1002/pds.5188,
author = {Requena, G and Wolf, A and Williams, R and Dedman, D and Quint, JK and Murray-Thomas, T and Pimenta, JM},
doi = {10.1002/pds.5188},
journal = {Pharmacoepidemiology and Drug Safety},
pages = {472--481},
title = {Feasibility of using Clinical Practice Research Datalink data to identify patients with chronic obstructive pulmonary disease to enrol into real-world trials},
url = {http://dx.doi.org/10.1002/pds.5188},
volume = {30},
year = {2021}
}

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TY  - JOUR
AB  - PurposeTo assess the feasibility of using Clinical Practice Research Datalink (CPRD) data for identifying populations of patients with chronic obstructive pulmonary disease (COPD) eligible for a hypothetical pragmatic trial.MethodsA retrospective multidatabase cohort study using CPRD primary care and linked secondary care data to describe the characteristics of populations of patients with COPD. Patients' demographic and lifestyle factors, comorbidity profile, spirometry measurements and treatment changes were evaluated, as was the distribution of followup time and types of losses during followup. Characteristics were evaluated using descriptive statistics.ResultsA total of 322 991 patients from 1148 primary care practices in the United Kingdom across two CPRD primary care databases, CPRD GOLD and CPRD Aurum, were potentially eligible to participate in a hypothetical trial using CPRD, starting on 31 December 2017. Patients with COPD in CPRD GOLD and CPRD Aurum were comparable in terms of age (median age 70 vs. 68 years), gender (50% vs. 52% male), disease severity (e.g., 25% vs. 24% Medical Research Council [MRC] dyspnoea score grades 3–5) and history of respiratory conditions (e.g., 43% vs. 38% asthma). High proportions of patients with COPD in CPRD GOLD and CPRD Aurum were available on 31 December 2012 for followup at 1, 2, and 5 years (92%, 85% and 67%, respectively).ConclusionsPatients and data from CPRD GOLD and CPRD Aurum were comparable across key aspects relevant to COPD trials. A pragmatic trial using CPRD to recruit patients with COPD is scientifically feasible.
AU  - Requena,G
AU  - Wolf,A
AU  - Williams,R
AU  - Dedman,D
AU  - Quint,JK
AU  - Murray-Thomas,T
AU  - Pimenta,JM
DO  - 10.1002/pds.5188
EP  - 481
PY  - 2021///
SN  - 1053-8569
SP  - 472
TI  - Feasibility of using Clinical Practice Research Datalink data to identify patients with chronic obstructive pulmonary disease to enrol into real-world trials
T2  - Pharmacoepidemiology and Drug Safety
UR  - http://dx.doi.org/10.1002/pds.5188
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000605989700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://onlinelibrary.wiley.com/doi/10.1002/pds.5188
UR  - http://hdl.handle.net/10044/1/88123
VL  - 30
ER  -

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