Publications

BibTex format

@article{Galani:2021:10.2147/COPD.S292978,
author = {Galani, J and Mulder, H and Rockhold, F and Weissler, H and Baumgartner, I and Berger, J and Blomster, J and Fowkes, G and Hiatt, W and Katona, B and Norgren, L and Mahaffey, K and Quint, J and Patel, M and Jones, S},
doi = {10.2147/COPD.S292978},
journal = {International Journal of COPD},
pages = {841--851},
title = {Association of chronic obstructive pulmonary disease with morbidity and mortality in patients with peripheral artery disease: insights from the EUCLID trial},
url = {http://dx.doi.org/10.2147/COPD.S292978},
volume = {16},
year = {2021}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Patients with chronic obstructive pulmonary disease (COPD) are at increased risk of developing lower extremity peripheral artery disease (PAD) and suffering PAD-related morbidity and mortality. However, the effect and burden of COPD on patients with PAD is less well defined. This post hoc analysis from EUCLID aimed to analyze the risk of major adverse cardiovascular events (MACE) and major adverse limb events (MALE) in patients with PAD and concomitant COPD compared with those without COPD, and to describe the adverse events specific to patients with COPD.Methods: EUCLID randomized 13,885 patients with symptomatic PAD to monotherapy with either ticagrelor or clopidogrel for the prevention of MACE. In this analysis, MACE, MALE, mortality, and adverse events were compared between groups with and without COPD using unadjusted and adjusted Cox proportional hazards model.Results: Of the 13,883 patients with COPD status available at baseline, 11% (n=1538) had COPD. Patients with COPD had a higher risk of MACE (6.02 vs 4.29 events/100 patient-years; p< 0.001) due to a significantly higher risk of myocardial infarction (MI) (3.55 vs 1.85 events/100 patient-years; p< 0.001) when compared with patients without COPD. These risks persisted after adjustment (MACE: adjusted hazard ratio (aHR) 1.30, 95% confidence interval [CI] 1.11– 1.52; p< 0.001; MI: aHR 1.45, 95% CI 1.18– 1.77; p< 0.001). However, patients with COPD did not have an increased risk of MALE or major bleeding. Patients with COPD were more frequently hospitalized for dyspnea and pneumonia (2.66 vs 0.9 events/100 patient-years; aHR 2.77, 95% CI 2.12– 3.63; p< 0.001) and more frequently discontinued study drug prematurely (19.36 vs 12.54 events/100 patient-years; p< 0.001; aHR 1.34, 95% CI 1.22– 1.47; p< 0.001).Conclusion: In patients with comorbid PAD and COPD, the risks of MACE, respiratory-related adverse events, and premature study drug discontinuation were
AU  - Galani,J
AU  - Mulder,H
AU  - Rockhold,F
AU  - Weissler,H
AU  - Baumgartner,I
AU  - Berger,J
AU  - Blomster,J
AU  - Fowkes,G
AU  - Hiatt,W
AU  - Katona,B
AU  - Norgren,L
AU  - Mahaffey,K
AU  - Quint,J
AU  - Patel,M
AU  - Jones,S
DO  - 10.2147/COPD.S292978
EP  - 851
PY  - 2021///
SN  - 1176-9106
SP  - 841
TI  - Association of chronic obstructive pulmonary disease with morbidity and mortality in patients with peripheral artery disease: insights from the EUCLID trial
T2  - International Journal of COPD
UR  - http://dx.doi.org/10.2147/COPD.S292978
UR  - http://hdl.handle.net/10044/1/88641
VL  - 16
ER  -

Download

ProfessorJenniferQuint

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)