Imperial College London

DrJesusRodriguez Manzano

Faculty of MedicineDepartment of Infectious Disease

Lecturer in Antimicrobial Resistance and Infectious Diseases







Commonwealth BuildingHammersmith Campus





Jesus Rodriguez Manzano received a BSc in Biological Sciences, an MSc in Advanced Microbiology and a PhD in Biotechnology and Environmental Microbiology from the University of Barcelona. After post-doctoral positions in the Division of Chemistry and Chemical Engineering at the California Institute of Technology (Caltech) and in the Department of Electrical and Electronic Engineering at Imperial College London, he moved to the Department of Infectious Disease as a non-clinical Lecturer in Antimicrobial Resistance and Infectious Diseases in the Faculty of Medicine.

He is a Co-Founder and CSO of ProtonDx Ltd, an Imperial spinout company developing diagnostic solutions to guide treatment decisions, optimise antimicrobial use and support infection control interventions; and the Deputy Director of the Centre for Antimicrobial Optimisation (CAMO) at Imperial College.

Dr Rodriguez Manzano has a strong interdisciplinary background in microbiology, molecular biology and bioengineering, and his research interest includes single-molecule technologies, machine learning applied to healthcare, and clinical diagnostics, with particular interest in low- and middle-income countries. He is the author of over 80 scientific publications and 14 international patent applications with over 2,800 citations.

Jesus' research publications can be found at the tab above, or on Google Scholar.

Selected Publications

Journal Articles

Pennisi I, Moniri A, Miscourides N, et al., 2022, Discrimination of bacterial and viral infection using host-RNA signatures integrated in a lab-on-chip platform, Biosensors & Bioelectronics, Vol:216, ISSN:0956-5663

Malpartida-Cardenas K, Miglietta L, Peng T, et al., 2022, Single-channel digital LAMP multiplexing using Amplification Curve Analysis, Sensors and Diagnostics, Vol:1, ISSN:2635-0998, Pages:465-468

Li HK, Kaforou M, Rodriguez-Manzano J, et al., 2021, Discovery and validation of a 3-gene signature to distinguish COVID-19 and other viral infections in emergency infectious disease presentations; a case-control then observational cohort study, The Lancet Microbe, Vol:2, ISSN:2666-5247, Pages:594-603

Miglietta L, Moniri A, Pennisi I, et al., 2021, Coupling machine learning and high throughput multiplex digital PCR enables accurate detection of carbapenem-resistant genes in clinical isolates, Frontiers in Molecular Biosciences, Vol:8, ISSN:2296-889X, Pages:1-11

Charani E, McKee M, Ahmad R, et al., 2021, Optimising antimicrobial use in humans-review of current evidence and an interdisciplinary consensus on key priorities for research, The Lancet Regional Health - Europe, Vol:7, ISSN:2666-7762, Pages:1-10

Rodriguez-Manzano J, Malpartida-Cardenas K, Moser N, et al., 2021, Handheld point-of-care system for rapid detection of SARS-CoV-2 extracted RNA in under 20 min, Acs Central Science, Vol:7, ISSN:2374-7943, Pages:307-317

Pennisi I, Rodriguez Manzano J, Moniri A, et al., 2021, Translation of a host blood RNA Signature distinguishing bacterial from viral infection into a platform suitable for development as a point-of-care test, Jama Pediatrics, Vol:175, ISSN:2168-6203, Pages:417-419

Moniri A, Miglietta L, Holmes A, et al., 2020, High-level multiplexing in digital PCR with intercalating dyes by coupling real-time kinetics and melting curve analysis., Analytical Chemistry, Vol:92, ISSN:0003-2700, Pages:14181-14188

Moniri A, Miglietta L, Malpartida Cardenas K, et al., 2020, Amplification curve analysis: Data-driven multiplexing using real-time digital PCR, Analytical Chemistry, Vol:92, ISSN:0003-2700, Pages:13134-13143

Rodriguez Manzano J, Moser N, Malpartida Cardenas K, et al., 2020, Rapid detection of mobilized colistin resistance using a nucleic acid based lab-on-a-chip diagnostic system, Scientific Reports, Vol:10, ISSN:2045-2322

Malpartida-Cardenas K, Miscourides N, Rodriguez-Manzano J, et al., 2019, Quantitative and rapid Plasmodium falciparum malaria diagnosis and artemisinin-resistance detection using a CMOS Lab-on-Chip platform, Biosensors & Bioelectronics, Vol:145, ISSN:0956-5663

Moniri A, Rodriguez-Manzano J, Malpartida-Cardenas K, et al., 2019, Framework for DNA quantification and outlier detection using multidimensional standard curves, Analytical Chemistry, Vol:91, ISSN:0003-2700, Pages:7426-7434

Ming D, Rawson T, Sangkaew S, et al., 2019, Connectivity of rapid-testing diagnostics and surveillance of infectious diseases, Bulletin of the World Health Organization, Vol:97, ISSN:0042-9686, Pages:242-244

Rodriguez-Manzano J, Moniri A, Malpartida-Cardenas K, et al., 2019, Simultaneous single-channel multiplexing and quantification of carbapenem-resistant genes using multidimensional standard curves, Analytical Chemistry, Vol:91, ISSN:0003-2700, Pages:2013-2020

Rodriguez-Manzano J, Karymov MA, Begolo S, et al., 2016, Reading out single-molecule digital RNA and DNA isothermal amplification in nanoliter volumes with unmodified camera phones, ACS Nano, Vol:10, ISSN:1936-0851, Pages:3102-3113

Witters D, Sun B, Begolo S, et al., 2014, Digital biology and chemistry, Lab on a Chip, Vol:14, ISSN:1473-0197, Pages:3225-3232

Sun B, Rodriguez-Manzano J, Selck DA, et al., 2014, Measuring Fate and Rate of Single-Molecule Competition of Amplification and Restriction Digestion, and Its Use for Rapid Genotyping Tested with Hepatitis C Viral RNA, Angewandte Chemie - International Edition, Vol:53, ISSN:1433-7851, Pages:8088-8092


Rodriguez Manzano J, Moniri A, Miglietta L, et al., 2021, Method of assay design

Cavuto M, Pennisi I, Rodriguez Manzano J, et al., 2021, Lid assembly for a sample tube, method of using the same to collect magnetic beads, and sample processing kit

Pennisi I, Rodriguez Manzano J, Miscourides N, et al., 2020, A method for determining a diagnostic outcome

Rodriguez Manzano J, Moniri A, Miglietta L, et al., 2020, Identifying a target nucleic acid

Georgiou P, Moniri A, Rodriguez Manzano J, 2019, A method for analysis of real-time amplification data, GB; WO, WO2019234247A1

Georgiou P, Moniri A, Moser N, et al., 2019, Devices and method for detecting an amplification event, GB; WO, WO2019234451A1

Georgiou P, Malpartida Cardenas K, Yu L-S, et al., 2019, Method for detecting a single nucleotide polymorphism (snp) using lamp and blocking primers, GB; WO, WO2019234251A1

Georgiou P, Yu L-S, Malpartida-Cardenas K, et al., 2019, Method for detecting a tandem repeat, GB; WO, WO2019234252A1

Toumazou C, Baig Mirza K, Rodriguez Manzano J, 2019, Molecule detection using aptamer nucleic acid duplex, GB; WO, WO2019138255A1

Ismagilov RF, Rodriguez Manzano J, Karymov M, et al., 2018, Devices and methods for direct visual detection and readout of single nucleic acid molecules, US WO, WO2017079696A1

Ismagilov, RF, Rodriguez Manzano J, et al., 2017, Enhanced nucleic acid identification and detection, US EP WO, WO2015058008A3

Ismagilov RF, Begolo S, Rodriguez Manzano J, 2016, Devices and Methods for Autonomous Measurements, US; WO, WO2016105508A3

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