Imperial College London

DrJesusRodriguez Manzano

Faculty of MedicineDepartment of Infectious Disease

Non-Clinical Lecturer in Antimicrobial Resistance and Infect







Electrical EngineeringSouth Kensington Campus






BibTex format

author = {Miscourides, N and Yu, L-S and Rodriguez-Manzano, J and Georgiou, P},
doi = {10.1109/TBCAS.2018.2851448},
journal = {IEEE Transactions on Biomedical Circuits and Systems},
pages = {1202--1214},
title = {A 12.8 k current-mode velocity-saturation ISFET array for on-chip real-time DNA detection},
url = {},
volume = {12},
year = {2018}

RIS format (EndNote, RefMan)

AB - This paper presents a large-scale CMOS chemical-sensing array operating in current mode for real-time ion imaging and detection of DNA amplification. We show that the current-mode operation of ion-sensitive field-effect transistors in velocity saturation devices can be exploited to achieve an almost perfect linearity in their input-output characteristics (pH-current), which are aligned with the continuous scaling trend of transistors in CMOS. The array is implemented in a 0.35-m process and includes 12.8 k sensors configured in a 2T per pixel topology. We characterize the array by taking into account nonideal effects observed with floating gate devices, such as increased pixel mismatch due to trapped charge and attenuation of the input signal due to the passivation capacitance, and show that the selected biasing regime allows for a sufficiently large linear range that ensures a linear pH to current despite the increased mismatch. The proposed system achieves a sensitivity of 1.03 A/pH with a pH resolution of 0.101 pH and is suitable for the real-time detection of the NDM carbapenemase gene in E. Coli using a loop-mediated isothermal amplification.
AU - Miscourides,N
AU - Yu,L-S
AU - Rodriguez-Manzano,J
AU - Georgiou,P
DO - 10.1109/TBCAS.2018.2851448
EP - 1214
PY - 2018///
SN - 1932-4545
SP - 1202
TI - A 12.8 k current-mode velocity-saturation ISFET array for on-chip real-time DNA detection
T2 - IEEE Transactions on Biomedical Circuits and Systems
UR -
UR -
UR -
UR -
VL - 12
ER -