Imperial College London

Dr Jose Sanchez-Alonso

Faculty of MedicineNational Heart & Lung Institute

Research Associate
 
 
 
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Contact

 

j.sanchez-alonso-mardones

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Summary

I’m an electrophysiologist; after completing my degree in Neurobiology I worked with Professor A. Colino in the University Complutense of Madrid, Spain; I become an expert in neuron physiology and patch-clamp technique. I completed my Neuroscience PhD in 2012, during that time I focussed on calcium and potassium currents and their relation to the intrinsic excitability of neurons, publishing in Neuroscience letters (2008); Neuroscience (2010, 2012 & 2017) and Journal of Physiology (2014).

In 2013 I joined the laboratory of functional microscopy at Imperial College London led by Professor Julia Gorelik. This gave me the opportunity to be involved in several projects studying nanoscale signalling domains in cardiac myocytes, both rat and human, normal and pathological. I am involved in discovering how the disorganisation of them contributes to arrhythmia. I had been looking at the precise location of voltage gated calcium channels on the cardiomyocyte membrane with nanoscale resolution. With the help of state-of-the-art scanning ion conductance microscopy equipped with “smart patch-clamp” I was able to locate functional channels on cardiomyocyte membrane and study their behaviour under different conditions, publishing part of this results in Circulation Research (2016) and extended this study focusing on human cardiomyocytes  (EbioMedicine, 2020). Recently I have been focusing on the role of sympathetic neurons in the regulation of cardiomyocytes, combining my two-background knowledge.

Publications

Journals

Schobesberger S, Wright PT, Poulet C, et al., 2020, beta(3)-Adrenoceptor redistribution impairs NO/cGMP/PDE2 signalling in failing cardiomyocytes, Elife, Vol:9, ISSN:2050-084X, Pages:1-15

More Publications