Imperial College London

Dr Jose Sanchez-Alonso

Faculty of MedicineNational Heart & Lung Institute

Research Associate







ICTEM buildingHammersmith Campus





  1. R. Medvedev, J. L. Sanchez-Alonso, C. Pagiatakis, N. Trayanova, M. Miragoli, G. Faggian, and J. Gorelik (2021). Local hyperactivation of L-type Ca2 channels, increased spontaneous Ca2 release activity and cellular hypertrophy in right ventricular myocytes from heart failure rats. Scientific Reports, 11, Article number: 4840
  2. R. Medvedev, J. L. Sanchez-Alonso, A. Alvarez-Laviada, S. Rossi, E. Dries, T. Schorn, V. B. Abdul-Salam, N. Trayanova, B. Wojciak-Stothard, M. Miragoli, G. Faggian, and J. Gorelik (2021). Nanoscale study of calcium handling remodeling in right ventricular cardiomyocytes following pulmonary hypertension. Hypertension, Hypertension. 2021;77:605–616.
  3. P. Gross, J. Johnoson, C. M. Romero, C. Poulet, J. L. Sanchez-Alonso, C. Lucarelli, J. Ross, J. Lambert, E. Varol, D. M. Eaton, M. Wallner, H. Kubo, R. M. Berretta, V. Rizzo, J. Elrod, A. Sabri, J. Gorelik, X. Chen and S. R. Houser (2020). Interaction of the joining region in Junctophilin-2 with the L-type Calcium channel is pivotal for cardiac dyad assembly and modulates intracellular Ca2 dynamics. Circulation Research, DOI: 10.1161/CIRCRESAHA.119.315715
  4. A. Sintou, C. Mansfield, A. Iacob, R. Chowdhury, S. Narodden, S. M. Rothery, R. Podovei, J. L. Sanchez-Alonso, E. Ferraro, P. Swiatlowska, S. E. Harding, S. Prasad, N. Rosenthal, J. Gorelik, and S. Sattler (2020). Mediastinal lymphadenopathy, class-switched auto-antibodies and myocardial immune-complexes during heart failure in rodents and humans. Frontiers Cell and Developmental Biology,
  5. P. Swiatlowska, J. L. Sanchez-Alonso, C. Mansfield, D. Scaini, Y. Korchev, P. Novak, and J. Gorelik (2020). Short-term Angiotensin II treatment regulates cardiac nanomechanics via microtubule modifications. Nanoscale, 12, 16315-16329.
  6. J. L. Sanchez-Alonso, A. Loucks, S. Schobesberger, A. M.van Cromvoirt, C. Poulet, R. A.Chowdhury, N.Trayanova, and J. Gorelik (2020). Nanoscale regulation of L-type calcium channels differentiates between ischemic and dilated cardiomyopathies. EBioMedicine, Jun 21;57:102845.
  7. S. Schobesberger, P. T. Wright, C. Poulet, J. L. Sanchez-Alonso, C. Mansfield, A. Friebe, S. E. Harding, J. Balligand, V. O. Nikolaev, J. Gorelik (2020). β3-Adrenoceptor Redistribution Impairs NO/cGMP/PDE2 Signalling in Failing Cardiomyocytes. eLife, e52221.
  8. C. Poulet, J.L. Sanchez-Alonso, P. Swiatlowskaa, F. Mouya, C. Lucarellia, A. Alvarez-Laviada, P. Gross, C. Terracciano, S. Houser, and J. Gorelik (2020). Junctophilin-2 tethers T-tubules and recruits functional L-type calcium channels to lipid rafts in adult cardiomyocytes. Cardiovascular research, DOI: 10.1093/cvr/cvaa033 .
  9. H-Q. Yang, M. Pérez-Hernández, J. L. Sanchez-Alonso, A. Shevchuk, J. Gorelik, E. Rothenberg, M. Delmar, and  W. A. Coetzee (2020). Ankyrin-G mediates targeting of both Na and KATP channels to the cardiac intercalated disc. eLife, e52373.
  10. P. Swiatlowska, J.L. Sanchez-Alonso, P. Wright, P. Novak, and Julia Gorelik (2020). Microtubules regulate cardiomyocyte transversal Young’s modulus. PNAS, Feb 11;117(6):2764-2766.
  11. F. Schultz*, P. Swiatlowska*, A. Alvarez-Laviada*, J.L. Sanchez-Alonso, Q. Song, A. A. F. de Vries, D. A. Pijnappels, E. Ongstad, V. Braga, E. Entcheva, R. G. Gourdie, Mi. Miragoli, and J. Gorelik (2019). Cardiomyocyte–myofibroblast contact dynamism is modulated by connexin-43. FASEB, Sep;33(9):10453-68.
  12. P.T. Wright, J.L. Sanchez-Alonso, C. Lucarelli, A. Alvarez-Laviada, C.E. Poulet, S.O. Bello, G. Faggian, C.M. Terracciano, and J. Gorelik (2018). Partial Mechanical Unloading of the Heart Disrupts L-Type Calcium Channel and Beta-Adrenoceptor Signaling Microdomains. Frontiers in Phisiology, 9:1302.  
  13. R. Veeraraghavan, G.S. Hoeker, A. Alvarez-Laviada, D. Hoagland, X. Wan, D. King, J.L. Sanchez-Alonso, C. Chen, J. Jourdan, L. Isom, I. Deschenes, J. Smith, J. Gorelik, S. Poelzing, R. and G. Gourdie. (2018). The Adhesion Function of the Sodium Channel Beta Subunit (β1) Contributes To Cardiac Action Potential Propagation. eLife, e37610.
  14. A. Sanchez-Aguilera, J.L. Sanchez-Alonso, M.A. Vicente-Torres and A. Colino. (2017). Role of low-voltage-activated calcium current and extracellular calcium in controlling the firing pattern of developing CA1 pyramidal neurons. Neuroscience, 6;344:89-101.
  15. J.L. Sanchez-Alonso, A. Bhargava, T. O'Hara, A.V. Glukhov, S. Schobesberger, M.B. Sikkel, Y.E. Korchev, A.R. Lyon, P.P. Punjabi, V.O. Nikolaev, N.A. Trayanova, J. Gorelik. (2016). Microdomain-Specific Modulation of L-type Calcium Channels Leads to Triggered  Ventricular Arrhythmia in Heart Failure. Circulation Research, 119(8):944-55.
  16. A. Shevchuk, S. Tokar, S. Gopal, J.L. Sanchez-Alonso, A.I. Tarasov, A.C. Vélez-Ortega, C. Chiappini, P. Rorsman, M.M. Stevens, J. Gorelik, G.I. Frolenkov, D. Klenerman, Y.E. Korchev. (2016).  Angular Approach Scanning Ion Conductance Microscopy. Biophysical Journal, 110(10):2252-65.
  17. M. Miragoli, J.L. Sanchez-Alonso, A. Bhargava, P.T. Wright, M. Sikkel, S. Schobesberger, I. Diakonov, P. Novak, A. Castaldi, P. Cattaneo, A.R. Lyon, M.J. Lab and J. Gorelik (2016). Microtubule-Dependent Mitochondria Alignment Regulates Calcium Release in Response to Nanomechanical Stimulus in Heart Myocytes. Cell Reports, 14(1):140-51.
  18. A. Leo-Macias*, E. Agullo-Pascual*, J.L. Sanchez-Alonso, S. Keegan, X. Lin, Fengxia-Lang, J. Gorelik, D. Fenyo, E. Rothenberg, M. Delmar (2016) Localization of NaV1.5 and N-cadherin in adult cardiac ventricle: Visualization of a functional adhesion/excitability node at the cardiac intercalated disc resolved at the nanoscale. Nature Communication, 20;7:10342.
  19. A.V. Glukhov*, M. Balycheva*, J.L. Sanchez-Alonso, A. Alvarez-Laviada, N. Bhogal, I. Diakonov, S. Schobesberger, P.P. Punjabi, S.R. Houser and J. Gorelik (2015). Direct evidence for microdomain–specific localization and remodeling of functional L-type calcium channels in rat and human atrial myocytes. Circulation. October 8, 115.018131
  20. M. Miragoli, M.H. Yacoub, I. El-Hamamsy, J.L. Sanchez-Alonso, A. Moshkov, N. Mongkoldhumrongkul, M. Padala, S. Paramagurunathan, P. Sarathchandra, Y.E. Korchev, J. Gorelik and A.H. Chester (2014). Side-specific mechanical properties of valve endothelial cells. A. Journal Physiol. Heart Circ. Physiol. 307:H15-24.
  21. A. Sanchez-Aguilera, J.L. Sanchez-Alonso, M.A. Vicente-Torres and A. Colino (2014). A novel short-term plasticity of intrinsic excitability in the hippocampal CA1 pyramidal cells. Journal of Physiology. 592:2845-64.
  22. J.L. Sanchez-Alonso, A. Sanchez-Aguilera, M.A. Vicente-Torres and A. Colino (2012). Intrinsic excitability is altered by hypothyroidism in the developing hippocampal CA1 pyramidal cells. Neuroscience. 207:37-51.
  23. J.L. Sanchez-Alonso, J. Muñoz-Cuevas, M.A. Vicente-Torres and A. Colino (2010). Role of low-voltage-activated calcium current on the firing pattern alteration induced by hypothyroidism in the rat hippocampus. Neuroscience. 171:993-1005.
  24. J.L. Sanchez-Alonso, J.V. Halliwell and A. Colino (2008). ZD7288 inhibits T-type calcium current in rat hippocampal pyramidal cells. Neuroscience Letters 439:275-280.