Publications
245 results found
Mann CJ, Anderson TA, Read J, et al., 1999, The structure of vitellogenin provides a molecular model for the assembly and secretion of atherogenic lipoproteins, JOURNAL OF MOLECULAR BIOLOGY, Vol: 285, Pages: 391-408, ISSN: 0022-2836
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- Citations: 167
Aitman TJ, Glazier AM, Wallace CA, et al., 1999, Identification of <i>Cd36</i> (<i>Fat</i>) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats, NATURE GENETICS, Vol: 21, Pages: 76-83, ISSN: 1061-4036
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- Citations: 616
Scott J, Navaratnam N, Carter C, 1998, Molecular modelling and the biosynthesis of apolipoprotein B containing lipoproteins, ATHEROSCLEROSIS, Vol: 141, Pages: S17-S24, ISSN: 0021-9150
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- Citations: 3
Richardson N, Navaratnam N, Scott J, 1998, Secondary structure for the apolipoprotein B mRNA editing site - AU-binding proteins interact with a stem loop, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 273, Pages: 31707-31717, ISSN: 0021-9258
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- Citations: 44
Aitman TJ, Pravenec M, Kurtz TW, et al., 1998, The spontaneously hypertensive rat: a model to dissect cellular defects in glucose and fatty acid metabolism., PATHOLOGIE BIOLOGIE, Vol: 46, Pages: 693-694, ISSN: 0369-8114
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- Citations: 6
Kooner JS, Baliga RR, Wilding J, et al., 1998, Abdominal obesity, impaired nonesterified fatty acid suppression, and insulin-mediated glucose disposal are early metabolic abnormalities in families with premature myocardial infarction, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol: 18, Pages: 1021-1026, ISSN: 1079-5642
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- Citations: 53
Navaratnam N, Fujino T, Bayliss J, et al., 1998, <i>Escherichia coli</i> cytidine deaminase provides a molecular model for ApoB RNA editing and a mechanism for RNA substrate recognition, JOURNAL OF MOLECULAR BIOLOGY, Vol: 275, Pages: 695-714, ISSN: 0022-2836
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- Citations: 120
Fujino T, Navaratnam N, Scott J, 1998, Human apolipoprotein B RNA editing deaminase gene (APOBEC1), GENOMICS, Vol: 47, Pages: 266-275, ISSN: 0888-7543
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- Citations: 22
Heath KE, Luong LA, Leonard JV, et al., 1997, The use of a highly informative CA repeat polymorphism within the abetalipoproteinaemia locus (4q22-24), PRENATAL DIAGNOSIS, Vol: 17, Pages: 1181-1186, ISSN: 0197-3851
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- Citations: 8
Scott J, 1997, Ribonucleic acid (RNA), McGraw-Hill Yearbook of Science & Technology 1998, Editors: Staff, Publisher: McGraw-Hill Companies, Pages: 332-335, ISBN: 9780070524187
Gotoda T, Scott J, Aitman TJ, 1997, Molecular screening of the human melanocortin-4 receptor gene: Identification of a missense variant showing no association with obesity, plasma glucose, or insulin, DIABETOLOGIA, Vol: 40, Pages: 976-979, ISSN: 0012-186X
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- Citations: 76
Shovlin CL, Hughes JMB, Scott J, et al., 1997, Characterization of endoglin and identification of novel mutations in hereditary hemorrhagic telangiectasia, AMERICAN JOURNAL OF HUMAN GENETICS, Vol: 61, Pages: 68-79, ISSN: 0002-9297
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- Citations: 130
Gotoda T, Manning BS, Goldstone AP, et al., 1997, Leptin receptor gene variation and obesity: Lack of association in a white British male population, HUMAN MOLECULAR GENETICS, Vol: 6, Pages: 869-876, ISSN: 0964-6906
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- Citations: 159
Aitman TJ, Gotoda T, Evans AL, et al., 1997, Quantitative trait loci for cellular defects in glucose and fatty acid metabolism in hypertensive rats, NATURE GENETICS, Vol: 16, Pages: 197-201, ISSN: 1061-4036
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- Citations: 132
Scott J, 1997, RNA editing - Message change for a fat controller, NATURE, Vol: 387, Pages: 242-243, ISSN: 0028-0836
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- Citations: 2
Thompson GR, Scott J, Walport MJ, et al., 1997, Grand rounds - Hammersmith Hospital - Hazards of running a marathon - Creatine kinase MB can be raised without myocardial infarction, BRITISH MEDICAL JOURNAL, Vol: 314, Pages: 1023-1025, ISSN: 0959-8138
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- Citations: 10
Aitman TJ, Godsland IF, Farren B, et al., 1997, Defects of insulin action on fatty acid and carbohydrate metabolism in familial combined hyperlipidemia, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol: 17, Pages: 748-754, ISSN: 1079-5642
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- Citations: 82
Kreuzer J, White AL, Knott TJ, et al., 1997, Amino terminus of apolipoprotein B suffices to produce recognition of malondialdehyde-modified low density lipoprotein by the scavenger receptor of human monocyte-macrophages., J Lipid Res, Vol: 38, Pages: 324-342, ISSN: 0022-2275
Malondialdehyde, a product of lipid peroxidation, produces threshold conversion of low density lipoprotein (LDL) to a form recognized by type I and type II scavenger receptors of monocyte-macrophages. To investigate whether localized domains of human apoB-100 protein provide recognition determinants, we tested the ability of several different apoB-bearing particles to interact with the scavenger receptor of human monocyte-macrophages. Genetically engineered, carboxyl-terminally truncated apoB proteins assembled into lipoprotein form were labeled by fluorescent dye. Fluorescence microscopy and quantitative fluorescent spectrophotometry showed that purified particles containing as little as 23% of the apoB amino-terminus were internalized by the scavenger receptor after, but not before, malondialdehyde modification. There was no recognition of the particles by the LDL receptor. Similar results were obtained with human plasma LDL homozygous for carboxyl-terminally truncated apoB-45.2. Liposome-incorporated fusion protein containing apoB residues 547-735 displayed specific uptake by the scavenger receptor without modification by malondialdehyde. In contrast, fusion proteins containing apoB residues 3,029-3,133 or a short amino terminal segment failed to interact. Thus, primary sequence presented by residues 1-1,084 sufficed to produce recognition of modified LDL by the scavenger receptor. These receptor-combining domains were sequestered when secreted in lipoprotein form and were expressed upon malondialdehyde modification. When packaged exogenously in liposome form, fusion protein containing apoB residues 547-735, containing approximately 4% of the primary sequence, mediated scavenger receptor-dependent uptake and hydrolysis. Our findings provide an additional function or the amino-terminal region of apoB and demonstrate that primary sequence presented by the first 2% of apoB-100 protein suffices to produce recognition on malondialdehyde-modified LDL by the scavenger r
Scott J, 1997, Polygenic Disorders, Molecular biology in medicine, Editors: Cox, Sinclair, Oxford, Publisher: Wiley-Blackwell, Pages: 129-148, ISBN: 9780632027859
Woods A, Salt I, Scott J, et al., 1996, The alpha 1 and alpha 2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro, FEBS LETTERS, Vol: 397, Pages: 347-351, ISSN: 0014-5793
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- Citations: 225
Leiper JM, Harrison GB, Bayliss J, et al., 1996, Systematic expression of the complete coding sequence of apoB-100 does not reveal transmembrane determinants., J Lipid Res, Vol: 37, Pages: 2215-2231, ISSN: 0022-2275
We have investigated the hypothesis that apolipoprotein B undergoes a regulated process of translocation into the endoplasmic reticulum (ER) which causes the protein to adopt a transmembrane configuration. Protein segments representing the complete coding sequence of apolipoprotein B were first expressed by in vitro translation of transcripts from seven overlapping transcripts. Two regions were identified (located at residue 2425 and between residues 4149 and 4348) that can undergo incomplete translocation into pancreatic microsomes. Ribosome pausing at these sites uncoupled translation from translocation, leading to the synthesis of large cytoplasmically oriented segments of protein. In contrast, when these two regions were expressed by transfection in cultured cells, transmembrane structures were not detected. Endogenous apolipoprotein B-100 synthesis in HepG2 cells generates a spectrum of nascent chains, indicating that ribosome pausing can also occur in intact cells. However, the cellular pause products were cotranslationally translocated. While endogenous apolipoprotein B-100 in HepG2 cells was fully translocated, discrete proteolytic fragments were generated from the amino terminus of the protein when proteases gained access to the lumen of permeabilized microsomes. These products were similar in size and sequence to apoliprotein B proteolytic fragments previously ascribed as the luminal domains of transmembrane apoB-100 molecules (Du, E. Z., Kurth, J., Wang, S. L., Humiston, P., and Davis, R. A. 1994. J. Biol. Chem. 269: 24169-24176).
Morrison JR, Paszty C, Stevens ME, et al., 1996, Apolipoprotein B RNA editing enzyme-deficient mice are viable despite alterations in lipoprotein metabolism, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 93, Pages: 7154-7159, ISSN: 0027-8424
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- Citations: 66
Baliga R, Lammertsma A, Rhodes C, et al., 1996, Positron emission tomography localises insulin resistance to skeletal muscle in premature coronary heart disease., HEART, Vol: 75, Pages: 48-48, ISSN: 1355-6037
Woods A, Cheung PCF, Smith FC, et al., 1996, Characterization of AMP-activated protein kinase beta and gamma subunits - Assembly of the heterotrimeric complex in vitro, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 271, Pages: 10282-10290, ISSN: 0021-9258
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- Citations: 214
AlMohammad A, Scott J, Beatt KJ, et al., 1996, Grand Rounds - Hammersmith Hospital - A physiology classic revisited after 60 years, BMJ-BRITISH MEDICAL JOURNAL, Vol: 312, Pages: 1029-1031, ISSN: 1756-1833
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- Citations: 1
Lamberg A, Jauhiainen M, Metso J, et al., 1996, The role of protein disulphide isomerase in the microsomal triacylglycerol transfer protein does not reside in its isomerase activity, BIOCHEMICAL JOURNAL, Vol: 315, Pages: 533-536, ISSN: 0264-6021
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- Citations: 55
Scott J, 1996, New chapter for the fat controller., Nature, Vol: 379, Pages: 113-114, ISSN: 0028-0836
Hughes SD, Rouy D, Navaratnam N, et al., 1996, Gene transfer of cytidine deaminase apoBEC-1 lowers lipoprotein(a) in transgenic mice and induces apolipoprotein B editing in rabbits, HUMAN GENE THERAPY, Vol: 7, Pages: 39-49, ISSN: 1043-0342
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- Citations: 28
Shovlin CL, Scott J, 1996, Inherited diseases of the vasculature, ANNUAL REVIEW OF PHYSIOLOGY, Vol: 58, Pages: 483-507, ISSN: 0066-4278
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- Citations: 24
NARCISI TME, SHOULDERS CC, CHESTER SA, et al., 1995, MUTATIONS OF THE MICROSOMAL TRIGLYCERIDE-TRANSFER-PROTEIN GENE IN ABETALIPOPROTEINEMIA, AMERICAN JOURNAL OF HUMAN GENETICS, Vol: 57, Pages: 1298-1310, ISSN: 0002-9297
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- Citations: 126
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